Standout Papers
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
2003
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage
1995 StandoutNobel
Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast
1999
Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA
1998
TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
1995
Which DNA polymerases are used for DNA-repair in eukaryotes?
1997
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
1997 NatureNobel
Requirement of DNA Polymerase Activity of Yeast Rad30 Protein for Its Biological Function
1999
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis
2002
High-Throughput Isolation of Caenorhabditis elegans Deletion Mutants
1999
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites
1997
Novel high-resolution characterization of ancient DNA reveals C > U-type base modification events as the sole cause of post mortem miscoding lesions
2007
A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy
1998
Over-production of Proteins inEscherichia coli: Mutant Hosts that Allow Synthesis of some Membrane Proteins and Globular Proteins at High Levels
1996 StandoutNobel
SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3
1992
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity
2006
Human DNA Repair Excision Nuclease
1995 StandoutNobel
Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases
1999
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
Base excision repair in yeast and mammals
2000
Nucleotide excision repair: From E. coli to man
1999 StandoutNobel
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
2008 Nature
DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint
1995
A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair
1997
Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA
1996
Ecology of prokaryotic viruses
2003 Standout
Mammalian base excision repair and DNA polymerase beta
1998
The roles of the eukaryotic DNA polymerases in DNA repair synthesis
1997
Characterization of Reaction Intermediates of Human Excision Repair Nuclease
1997 StandoutNobel
DNA EXCISION REPAIR
1996
Stereoselectivity of Human Nucleotide Excision Repair Promoted by Defective Hybridization
1998
Mrc1 transduces signals of DNA replication stress to activate Rad53
2001
When Checkpoints Fail
1997 StandoutNobel
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
1997
The complete mitochondrial DNA genome of an unknown hominin from southern Siberia
2010 StandoutNatureNobel
Modulation of DNA Damage and DNA Repair in Chromatin
1998
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
1995
Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide excision repair
1999
A kinase from fission yeast responsible for blocking mitosis in S phase
1995 Nature
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
1997
Involvement of Brca2 in DNA Repair
1998 StandoutNobel
The Topodynamics of Incision of UV-irradiated Covalently Closed DNA by the Escherichia coli Uvr(A)BC Endonuclease
1996
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair
2001
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
2002
The Ubiquitin Ligase Activity in the DDB2 and CSA Complexes Is Differentially Regulated by the COP9 Signalosome in Response to DNA Damage
2003
Effect of DNA lesions on transcription elongation
1999
A role for p53 in base excision repair
2001
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
2000 Nature
Novel DNA Polymerases Offer Clues to the Molecular Basis of Mutagenesis
1999
Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein
1997
The genetics of cell cycle checkpoints
1995
Purification and Characterization of the XPF-ERCC1 Complex of Human DNA Repair Excision Nuclease
1995 StandoutNobel
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
2002 StandoutNature
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
DNA Damage, Aging, and Cancer
2009 Standout
Model for XPC-independent Transcription-coupled Repair of Pyrimidine Dimers in Humans
1997 StandoutNobel
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway
1997
Repair of UV damage in the fission yeast Schizosaccharomyces pombe
2000
Abnormal regulation of DDB2 gene expression in xeroderma pigmentosum group E strains
2001
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
2003 Nature
A 3′→ 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and Transcription
1996
Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome
1995 StandoutNobel
Checkpoint activation regulates mutagenic translesion synthesis
2003
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
DNA REPAIR IN EUKARYOTES
1996
Replication errors: cha(lle)nging the genome
1998
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
1997
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
1998 Standout
Protein complexes in nucleotide excision repair
1999
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Mitotic DNA damage and replication checkpoints in yeast
1998
Structural Determinants for Substrate Binding and Catalysis by the Structure-specific Endonuclease XPG
2003
Subunit Interactions in Yeast Transcription/Repair Factor TFIIH
2000 StandoutNobel
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
1999 Nature
Cleavage of Substrates with Mismatched Nucleotides by Flap Endonuclease-1
1999
DNA Excision Repair Assays
1997
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
A multistep damage recognition mechanism for global genomic nucleotide excision repair
2001
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair
1993 StandoutNobel
Induction of DNA Replication-mediated Double Strand Breaks by Psoralen DNA Interstrand Cross-links
2003
Conserved domains in DNA repair proteins and evolution of repair systems
1999
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
1998 Nature
DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision Repair
2002 StandoutNobel
A newly identified DNA ligase of Saccharomyces cerevisiaeinvolved in RAD52-independent repair of DNA double-strand breaks
1997 StandoutNobel
Microsatellite Instability in Human Cancer: A Prognostic Marker for Chemotherapy?
1999
Genes For Tfb2, Tfb3, and Tfb4 Subunits of Yeast Transcription/Repair Factor IIH
1997 StandoutNobel
The human REV1 gene codes for a DNA template-dependent dCMP transferase
1999
Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
1999
Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease
1996
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
A yeast whole cell extract supports nucleotide excision repair and RNA polymerase II transcription in vitro
1996
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
2000
The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
1995
Damaged DNA-binding Protein DDB Stimulates the Excision of Cyclobutane Pyrimidine Dimers in Vitro in Concert with XPA and Replication Protein A
2001
Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I
1997 StandoutNobel
A plethora of lesion-replicating DNA polymerases
1999
The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis
1999
Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair
1998
Novel Human and Mouse Homologs of Saccharomyces cerevisiae DNA Polymerase η
1999
Overproduction, Purification, and Characterization of the XPC Subunit of the Human DNA Repair Excision Nuclease
1996 StandoutNobel
The Non-catalytic Function of XPG Protein during Dual Incision in Human Nucleotide Excision Repair
1997 StandoutNobel
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21
1995 StandoutNobel
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
2007 Standout
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
1999
The TFB4 Subunit of Yeast TFIIH Is Required for Both Nucleotide Excision Repair and RNA Polymerase II Transcription
1999
Excision Repair in Mammalian Cells
1995 StandoutNobel
The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 Genes Are Required for Tolerating Irreparable, Ultraviolet-Induced DNA Damage
1998 StandoutNobel
ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes
2001
Binding of double-strand breaks in DNA by human Rad52 protein
1999 Nature
The α/β fold uracil DNA glycosylases: a common origin with diverse fates
2000
Recognition of DNA Adducts by Human Nucleotide Excision Repair
1996
Characterization of defective nucleotide excision repair in XPC mutant mice
1997
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Stable and specific association between the yeast recombination and DNA repair proteins RAD1 and RAD10 in vitro.
1992
Postnatal Growth Failure, Short Life Span, and Early Onset of Cellular Senescence and Subsequent Immortalization in Mice Lacking the Xeroderma Pigmentosum Group G Gene
1999
Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
1998
DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
2002
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
1997 StandoutNobel
Recombination-dependent deletion formation in mammalian cells deficient in the nucleotide excision repair gene ERCC1
1997
DNA REPAIR MECHANISMS FOR THE RECOGNITION AND REMOVAL OF DAMAGED DNA BASES
1999
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
2000
Quality Control by DNA Repair
1999 StandoutScienceNobel
Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest
1995 Science
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
The Yeast TFB1 and SSL1 Genes, Which Encode Subunits of Transcription Factor IIH, Are Required for Nucleotide Excision Repair and RNA Polymerase II Transcription
1995 StandoutNobel
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
1994 StandoutNobel
Eukaryotic DNA mismatch repair
1999
Interactions Involving the Human RNA Polymerase II Transcription/Nucleotide Excision Repair Complex TFIIH, the Nucleotide Excision Repair Protein XPG, and Cockayne Syndrome Group B (CSB) Protein
1996
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
1999
UmuD′ 2 C is an error-prone DNA polymerase, Escherichia coli pol V
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
1999
In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair
2001 StandoutNobel
Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system.
1996 StandoutNobel
Yeast nucleotide excision repair proteins Rad2 and Rad4 interact with RNA polymerase II basal transcription factor b (TFIIH).
1994 StandoutNobel
Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair
2002
Bipartite substrate discrimination by human nucleotide excision repair
1997
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
2004 StandoutNobel
A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription.
1996
DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication.
1996
Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1, N 6 -ethenoadenine and hypoxanthine but not of 3, N 4 -ethenocytosine or 8-oxoguanine
1997
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
2000
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
1999 Science
DNA end-joining: from yeast to man
1998
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.
1996
Recombinational DNA Repair of Damaged Replication Forks inEscherichia coli: Questions
2001
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
1997 Standout
Expansion and Length-Dependent Fragility of CTG Repeats in Yeast
1998 Science
DNA Double-Strand Breaks
2002 StandoutNobel
Role of a Complex Containing Rad17, Mec3, and Ddc1 in the Yeast DNA Damage Checkpoint Pathway
1999
Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
1996 Science
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.
1996
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
DNA end-joining catalyzed by human cell-free extracts
1998
Affinity of Yeast Nucleotide Excision Repair Factor 2, Consisting of the Rad4 and Rad23 Proteins, for Ultraviolet Damaged DNA
1998
Initiation of DNA Interstrand Cross-Link Repair in Humans: the Nucleotide Excision Repair System Makes Dual Incisions 5′ to the Cross-linked Base and Removes a 22- to 28-Nucleotide-long Damage-Free Strand
1997 StandoutNobel
Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway
1997
Human DNA Repair Genes
2001 StandoutScienceNobel
Translocation of a UV-damaged DNA binding protein into a tight association with chromatin after treatment of mammalian cells with UV light
1997
The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.
1996
hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum
1999 Science
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48DDB2 and p53
2003
A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil
1999
Cell Cycle Checkpoints: Preventing an Identity Crisis
1996 StandoutScience
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae
2000
The RAD7, RAD16, and RAD23 Genes of Saccharomyces cerevisiae: Requirement for Transcription-Independent Nucleotide Excision Repair In Vitro and Interactions between the Gene Products
1997 StandoutNobel
Recognition and Repair of Compound DNA Lesions (Base Damage and Mismatch) by Human Mismatch Repair and Excision Repair Systems
1997 StandoutNobel
Works of Wolfram Siede being referenced
3 Cellular Responses to DNA Damage in Yeast
1991
Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest
2000
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability
1998
Checkpoint Arrest Signaling in Response to UV Damage Is Independent of Nucleotide Excision Repair in Saccharomyces cerevisiae
2003
Spontaneous DNA Damage in Saccharomyces cerevisiae Elicits Phenotypic Properties Similar to Cancer Cells
2004
Characterization of DNA Damage-stimulated Self-interaction ofSaccharomyces cerevisiae Checkpoint Protein Rad17p
2001
Regulation of the RAD2 gene of Saccharomyces cervisiae
1989
Regulation of the yeast RAD2 gene DNA damage-dependent induction correlates with protein binding to regulatory sequences and their deletion influences survival
1992
Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents.
1994
Cloning and Characterization of RAD17, a Gene Controlling Cell Cycle Responses to DNA Damage in Saccharomyces Cerevisiae
1996
Interactions among genes controlling sensitivity to radiation (RAD) and to alkylation by nitrogen mustard (SNM) in yeast
1982
RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae.
1993
Analysis of mutagenic DNA repair in a thermoconditional repair mutant of Saccharomyces cerevisiae
1983
Effects of multiple yeast rad3 mutant alleles on UV sensitivity, mutability, and mitotic recombination
1990
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment
1996
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.
1994
The RAD24 (= Rs 1) Gene Product of Saccharomyces cerevisiae Participates in Two Different Pathways of DNA Repair
1987
Influence of different inhibitors on the activity of theRAD54 dependent step of DNA repair inSaccharomyces cerevisiae
1985
The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination
1996
DNA Repair and Mutagenesis
2005 Standout
Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene
1995
Mutational inactivation of the Saccharomyces cerevisiae RAD4 gene in Escherichia coli
1987