Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas
2009
Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner
2015
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
2011
Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH -Mutant Gliomas
2014
IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas
2009
Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951
2012
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination
2017
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
2009 Science
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo
2012
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
2010
IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
2010
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
2010
Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations
2009
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide
2009
Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities
2006
Mutation Analysis of Isocitrate Dehydrogenase in Acute Lymphoblastic Leukemia
2012
gp340 Expressed on Human Genital Epithelia Binds HIV-1 Envelope Protein and Facilitates Viral Transmission
2007 StandoutNobel
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
2019 StandoutNobel
Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants
2012
IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
2010
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function
2010 StandoutNobel
Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma
2012
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas
2009
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
2012
Molecular heterogeneity of meningioma with INI1 mutation
2003
IDH1andIDH2Mutations in Gliomas
2009 Standout
Widespread mRNA Association with Cytoskeletal Motor Proteins and Identification and Dynamics of Myosin-Associated mRNAs in S. cerevisiae
2012 StandoutNobel
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
2011
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
2010 Standout
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
2010
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
2009
IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas
2015
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
2006 Standout
IDH mutations in glioma and acute myeloid leukemia
2010
Glioblastoma and Other Malignant Gliomas
2013 Standout
Malignant Gliomas with Primitive Neuroectodermal Tumor‐like Components: A Clinicopathologic and Genetic Study of 53 Cases
2008
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
AMPA receptors promote perivascular glioma invasion via β1 integrin–dependent adhesion to the extracellular matrix
2008
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
SWI/SNF nucleosome remodellers and cancer
2011 Standout
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
2012
The Epigenomics of Cancer
2007 Standout
Inhibition of angiogenesis and invasion in malignant gliomas
2007
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
2009 StandoutNature
IDH mutations in acute myeloid leukemia
2012
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
2013
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
2016 Standout
The SWI/SNF complex — chromatin and cancer
2004
DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration?
2003
Mitochondria: In Sickness and in Health
2012 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
The 1p-Encoded Protein Stathmin and Resistance of Malignant Gliomas to Nitrosoureas
2007
Molecular characterisation of SMARCB1 and NF2 in familial and sporadic schwannomatosis
2008
Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function
2007
Population-Based Studies on Incidence, Survival Rates, and Genetic Alterations in Astrocytic and Oligodendroglial Gliomas
2005
Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas
2010
Guidelines on management of low‐grade gliomas: report of an EFNS–EANO* Task Force
2010
Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis
2008
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Targeting apoptosis in cancer therapy
2020 Standout
Epidemiology of Brain Tumors
2007
Anaplastic Oligodendroglioma and Oligoastrocytoma
2007
IDH mutation impairs histone demethylation and results in a block to cell differentiation
2012 Nature
IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO
2015
Malignant Gliomas in Adults
2008 Standout
Insights into RNA structure and function from genome-wide studies
2014 StandoutNobel
IDH1 mutation of gliomas with long-term survival analysis
2012
Mutational Heterogeneity in Human Cancers: Origin and Consequences
2009
Two types of chromosome 1p losses with opposite significance in gliomas
2005
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1
2005
TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations: Figure 1
2011
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Characterization of R132H Mutation‐specific IDH1 Antibody Binding in Brain Tumors
2009
Primary brain tumours in adults
2012 Standout
IDH1 and IDH2 Mutations in Gliomas
2013
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
2015
New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein
2010 StandoutNobel
Epithelioid GBMs Show a High Percentage of BRAF V600E Mutation
2013
DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma
2010
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma
2014
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas
2016
The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma
2010
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
2020 Standout
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma
2011
IDH1andIDH2Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia WithNPM1Mutation WithoutFLT3Internal Tandem Duplication
2010
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015
2018 Standout
Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
2010
CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010
2013 Standout
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
RASSF1A expression level in primary epithelial tumors of various locations
2012
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016
2019 Standout
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Metabolic reprogramming and cancer progression
2020 StandoutScience
Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas
2009
Cancer Genome Landscapes
2013 StandoutScience
HDACs and HDAC Inhibitors in Cancer Development and Therapy
2016
Imaging the glycome
2008 StandoutNobel
Genetic Pathways to Glioblastoma
2004
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
The Definition of Primary and Secondary Glioblastoma
2012
Malignant glioma: genetics and biology of a grave matter
2001
Works of Wolf Mueller being referenced
Epigenetic Silencing of Death Receptor 4 Mediates Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance in Gliomas
2009
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
2009 Standout
CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
2012
Analysis of the IDH1 codon 132 mutation in brain tumors
2008
Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma
2014
Downregulation of RUNX3 and TES by hypermethylation in glioblastoma
2006
In Situ Analysis of Integrin and Growth Factor Receptor Signaling Pathways in Human Glioblastomas Suggests Overlapping Relationships with Focal Adhesion Kinase Activation
2005
Impact of Genotype and Morphology on the Prognosis of Glioblastoma
2002
Genetic Signature of Oligoastrocytomas Correlates with Tumor Location and Denotes Distinct Molecular Subsets
2002
Clonal Analysis in Recurrent Astrocytic, Oligoastrocytic and Oligodendroglial Tumors Implicates IDH1- Mutation as Common Tumor Initiating Event
2012
Rare mutations of the DMBT1 gene in human astrocytic gliomas
2002
Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation
2009
INI1 mutations in meningiomas at a potential hotspot in exon 9
2001
Clonal Analysis in Glioblastoma with Epithelial Differentiation
2001
Molecular Genetic Analysis of Oligodendroglial Tumors
2005
RASSF1A, BLU, NORE1A, PTEN and MGMT Expression and Promoter Methylation in Gliomas and Glioma Cell Lines and Evidence of Deregulated Expression of de novo DNMTs
2008
Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation
2015
PCR‐ and Restriction Endonuclease‐Based Detection of IDH1 Mutations
2009
Inhomogeneous distribution of Iba‐1 characterizes microglial pathology in Alzheimer's disease
2016