Citation Impact
Citing Papers
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints
2012
Colorectal cancer statistics, 2023
2023 Standout
De novo design and directed folding of disulfide-bridged peptide heterodimers
2022 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Cyclic peptide therapeutics: past, present and future
2017
Accurate de novo design of heterochiral protein–protein interactions
2024 StandoutNobel
Miniproteins as a Powerful Modality in Drug Development
2020
Bowel Disorders
2016 Standout
Effects of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation: A Meta-analysis
2013
ESPEN guideline: Clinical nutrition in surgery
2017 Standout
Diaminodiacid Bridges to Improve Folding and Tune the Bioactivity of Disulfide‐Rich Peptides
2015
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Separation and identification of trinucleotide–melphalan adducts from enzymatically digested DNA using HPLC–ESI–MS
2008
Two Randomized Trials of Linaclotide for Chronic Constipation
2011
A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation
2012
The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease
2015
Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate
2013
Irritable bowel syndrome
2016 Standout
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
2015
A bulged stem tethers Est1p to telomerase RNA in budding yeast
2002 StandoutNobel
Designing hydrogels for controlled drug delivery
2016 Standout
In vitro-engineered non-antibody protein therapeutics
2017
Analysis of anticancer drugs: A review
2011 Standout
American Gastroenterological Association Institute Technical Review on the Pharmacological Management of Irritable Bowel Syndrome
2014
Fluids and gastrointestinal function
2011
Themes in RNA-protein recognition
1999
De novo design of buttressed loops for sculpting protein functions
2024 StandoutNobel
Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNA
2002 StandoutNobel
Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression
2021 StandoutNobel
Trends in peptide drug discovery
2021
Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety
2012
Irritable Bowel Syndrome
2015 Standout
Orally Absorbed Cyclic Peptides
2017
Emerging Frontiers in Drug Delivery
2016
The Current State of Peptide Drug Discovery: Back to the Future?
2017
Diagnosis and Treatment of Parkinson Disease
2020 Standout
The stem-loop binding protein forms a highly stable and specific complex with the 3′ stem-loop of histone mRNAs
2001 StandoutNobel
Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle
2001 StandoutNobel
Recognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor Complex
2001 StandoutNobel
Computational Evolution of Threonine-Rich β-Hairpin Peptides Mimicking Specificity and Affinity of Antibodies
2019 StandoutNobel
The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers
2021
Chlorambucil-Adducts in DNA Analyzed at the Oligonucleotide Level Using HPLC-ESI MS
2009
Works of Wilmin Bartolini being referenced
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
2010
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
2010
RNA Structure Inhibits the TRAP ( rp RNA-binding AttenuationProtein)-RNA Interaction
1998
Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
2012
Identification of single stranded regions of DNA by enzymatic digestion with matrix-assisted laser desorption/ionization analysis
1999