Citation Impact
Citing Papers
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
2004 StandoutNobel
Navigating the protein fitness landscape with Gaussian processes
2012 StandoutNobel
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Physically realistic homology models built with rosetta can be more accurate than their templates
2006 StandoutNobel
Protein stability promotes evolvability
2006 StandoutNobel
Progress towards the easier use of P450 enzymes
2006
Photo-driven molecular devices
2006 StandoutNobel
Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution
2011
High throughput assay for cytochrome P450 BM3 for screening libraries of substrates and combinatorial mutants
2002
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
[8] Raman spectroscopic studies of the structures, energetics and bond distortions of substrates bound to enzymes
1999
Metal-Substituted Protein MRI Contrast Agents Engineered for Enhanced Relaxivity and Ligand Sensitivity
2010 StandoutNobel
The interfacial binding surface of phospholipase A2s
2006
Synthetic Inhibitors of Elastase
1994
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
Laboratory evolution of cytochrome P450 BM‐3 monooxygenase for organic cosolvents
2003 StandoutNobel
Directed Evolution of the Fatty-Acid Hydroxylase P450 BM-3 into an Indole-Hydroxylating Catalyst
2000
Rational re‐design of the substrate binding site of flavocytochrome P450 BM3
2000
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
1996 StandoutNature
The Active Site of the Thermophilic CYP119 from Sulfolobus solfataricus
2000
Use of Kinetic Isotope Effects to Delineate the Role of Phenylalanine 87 in P450BM-3
2002
A Continuous Spectrophotometric Assay for P450 BM-3, a Fatty Acid Hydroxylating Enzyme, and Its Mutant F87A
1999
Peptide Aldehyde Inhibitors of Hepatitis A Virus 3C Proteinase
1995
Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin
2012 StandoutNobel
Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites
1998 StandoutNobel
Mechanism of inhibition of human secretory phospholipase A2 by flavonoids: rationale for lead design
2007
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Inhibiting Bacterial Fatty Acid Synthesis
2006
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Hydroxylation activity of P450 BM-3 mutant F87V towards aromatic compounds and its application to the synthesis of hydroquinone derivatives from phenolic compounds
2004
2 Inhibitors of Human Leukocyte Elastase
1994
Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis
2001
P450BM3(CYP102A1): connecting the dots
2011
Chloroketone Hydrolysis by Chymotrypsin and N-Methylhistidyl-57-chymotrypsin: Implications for the Mechanism of Chymotrypsin Inactivation by Chloroketones
1994
Protein engineering of Bacillus megaterium CYP102
2001
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine
2010 StandoutNobel
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor
2010
P450 BM3: the very model of a modern flavocytochrome
2002
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Three-Dimensional Structure of Chymotrypsin Inactivated with (2S)-N-Acetyl-L-alanyl-L-phenylalanyl .alpha.-chloroethane: Implications for the Mechanism of Inactivation of Serine Proteases by Chloroketones
1994
Deuterium labelling in NMR structural analysis of larger proteins
1990
Infrared spectroscopy of proteins
2007 Standout
Microbial P450 enzymes in biotechnology
2004
Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene ω-hydroxylase CYP4C7
2009
The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid
1997
Study of the Structural Dynamics of the E. coli 70S Ribosome Using Real-Space Refinement
2003 StandoutNobel
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Crystal Structure of the Extracellular Domain from P0, the Major Structural Protein of Peripheral Nerve Myelin
1996
Enzymatic hydroxylation reactions
2000
Implications of a consensus recognition site for phosphatidylcholine separate from the active site in cobra venom phospholipases A2
1992
Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase
2002 StandoutNobel
Rational evolution of a medium chain-specific cytochrome P -450 BM-3 variant
2001
Genome-wide detection and characterization of positive selection in human populations
2007 StandoutNature
Conformational Plasticity and Structure/Function Relationships in Cytochromes P450
2010
Protein structure determination in solution by NMR spectroscopy.
1990 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Inhibition of serine proteases by peptidyl fluoromethyl ketones
1986
Positive Allosteric Systems Designed on Dynamic Supramolecular Scaffolds: Toward Switching and Amplification of Guest Affinity and Selectivity
2001
Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton
2002
Energetics of the Catalytic Reaction of Ribonuclease A: A Computational Study of Alternative Mechanisms
1998 StandoutNobel
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
C-H Bond Functionalization in Complex Organic Synthesis
2006 StandoutScience
The selective inactivation of thiol proteasesin vitro andin vivo
1984
Understanding and exploiting C–H bond activation
2002 StandoutNature
Tuning P450 Enzymes as Oxidation Catalysts
2012
Directed Evolution of the Fatty-Acid Hydroxylase P450 BM-3 into an Indole-Hydroxylating Catalyst
2000
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Apparent NAC Effect in Chorismate Mutase Reflects Electrostatic Transition State Stabilization
2003 StandoutNobel
FTIR studies of hydrogen bonding between α,β-unsaturated esters and alcohols
1996
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1991 StandoutScience
Vibrational Structure of GDP and GTP Bound to RAS: An Isotope-Edited FTIR Study
2001
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
1996 StandoutScience
High-Resolution X-ray Crystallography Reveals Precise Binding Interactions between Human Nonpancreatic Secreted Phospholipase A2 and a Highly Potent Inhibitor (FPL67047XX)
1996
How Important Are Quantum Mechanical Nuclear Motions in Enzyme Catalysis?
1996 StandoutNobel
Accurate protein structure modeling using sparse NMR data and homologous structure information
2012 StandoutNobel
A Redox-Switchable α-Cyclodextrin-Based [2]Rotaxane
2008 StandoutNobel
Active and Inactive Forms of the Transition-state Analog Protease Inhibitor Leupeptin: Explanation of the Observed Slow Binding of Leupeptin to Cathepsin B and Papain
1989
Quantum-Classical Molecular Dynamics Simulations of Proton Transfer Processes in Molecular Complexes and in Enzymes
1996
Comparative Protein Structure Modeling of Genes and Genomes
2000 Standout
Comparative Protein Structure Modeling Using MODELLER
2007 Standout
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity
2012
Engineering Cytochrome P450 BM3 for Terminal Alkane Hydroxylation
2006 StandoutNobel
Modification of the fatty acid specificity of cytochrome P450 BM-3 from Bacillus megaterium by directed evolution: a validated assay
2001
Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm
2001
Mechanism of action of cysteine proteinases: oxyanion binding site is not essential in the hydrolysis of specific substrates
1985
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Phospholipase A2 inhibitors in inflammation
2001
Roles of key active-site residues in flavocytochrome P450 BM3
1999
Computer Simulation Studies of the Catalytic Mechanism of Human Aldose Reductase
2000 StandoutNobel
Origin of the Catalytic Power of Acetylcholinesterase: Computer Simulation Studies
1998 StandoutNobel
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
Fatty Acid-Induced Alteration of the Porphyrin Macrocycle of Cytochrome P450 BM3
1998
Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate
1990 Science
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C—H Functionalization
2013
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Comparative Protein Structure Modeling Using Modeller
2006 Standout
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of William U. Primrose being referenced
Proton NMR studies of bovine and porcine phospholipase A2: assignment of aromatic resonances and evidence for a conformational equilibrium in solution
1989
NMR Studies of Substrate Binding to Cytochrome P450 BM3: Comparisons to Cytochrome P450 cam
1995
Inhibitors of phosphopantetheine adenylyltransferase
2003
Design and synthesis of some substrate analog inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex
1992
Changes in the structure of bovine phospholipase A2 upon micelle binding
1995
Inhibition of trypsin by carbobenzyloxylysyl chloromethyl ketone: 13C NMR and x-ray diffraction analyses of the enzyme-inhibitor complex
1986
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase
1997
Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity
1995
Structure and stereochemistry of tetrahedral inhibitor complexes of papain by direct NMR observation
1983
ChemInform Abstract: An Unusual Matrix of Stereocomplementarity in the Hydroxylation of Monohydroxy Fatty Acids Catalyzed by Cytochrome P450 from Bacillus megaterium with Potential Application in Biotransformations.
2000
A Model for Human Cytochrome P450 2D6 Based on Homology Modeling and NMR Studies of Substrate Binding
1996
The binding of amide substrate analogues to phospholipase A2. Studies by 13C-nuclear-magnetic-resonance and infrared spectroscopy
1992
A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation
1997
An unusual matrix of stereocomplementarity in the hydroxylation of monohydroxy fatty acids catalysed by cytochrome P450 from Bacillus megaterium with potential application in biotransformations
1999
Carbon-13 NMR study of the ionizations within a trypsin-chloromethyl ketone inhibitor complex
1985