Standout Papers
Citation Impact
Citing Papers
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Cloning and Functional Analysis of the Promoter for KDR/flk-1, a Receptor for Vascular Endothelial Growth Factor
1995
β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB
2002
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
1996 Nature
Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
2011 StandoutNobel
Characterization of the Genes for Mouse LERK-3/Ephrin-A3 (Epl3), Mouse LERK-4/Ephrin-A4 (Epl4), and Human LERK-6/Ephrin-A2 (EPLG6): Conservation of Intron/Exon Structure
1998
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
2001
Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation
2000
Applying the principles of stem-cell biology to cancer
2003
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
1995 Nature
Prospective Identification, Isolation by Flow Cytometry, and In Vivo Self-Renewal of Multipotent Mammalian Neural Crest Stem Cells
1999
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis
1999
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
1995 StandoutNature
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
1997
Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map
1995
In vitro and in vivo expansion of hematopoietic stem cells
2004
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
2002
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
The Biology of Hematopoietic Stem Cells
1995
Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains
1995
Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
2011
Therapeutic implications of cancer stem cells
2003
Wnt signaling: a common theme in animal development
1997 Standout
Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells
1996
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis
1996
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
1993 Standout
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Odorant Receptors Govern the Formation of a Precise Topographic Map
1998 StandoutNobel
Comparative gene expression in hematopoietic progenitor cells derived from embryonic stem cells
2002
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Molecular Cloning of Two Novel Transmembrane Ligands for Eph-Related Kinases (LERKS) that are Related to LERK-2
1996
A role for Wnt signalling in self-renewal of haematopoietic stem cells
2003 StandoutNature
Lymphocyte Development from Stem Cells
1992
Molecular and biological properties of vascular endothelial growth factor
1999
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
2002 Nature
Vascular endothelial growth factor
1996
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis
1995
Mechanisms of angiogenesis
1997 StandoutNature
The entorhinal grid map is discretized
2012 StandoutNatureNobel
Vascular endothelial growth factor
1993
The biology of leptin: a review.
1998
Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
1997
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
1999
Interaction of the Flt-1 Tyrosine Kinase Receptor with the p85 Subunit of Phosphatidylinositol 3-Kinase
1995
Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System
1996
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells
1997
Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1
1998
Regional Suppression of Tumor Growth by In Vivo Transfer of a cDNA Encoding a Secreted Form of the Extracellular Domain of the flt-1 Vascular Endothelial Growth Factor Receptor
1998
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Identification of human brain tumour initiating cells
2004 StandoutNature
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Vascular endothelial growth factor receptor‐2: Its unique signaling and specific ligand, VEGF‐E
2003
Wnt signalling in stem cells and cancer
2005 StandoutNature
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
1997
A novel endothelial tyrosine kinase cDNA homologous to platelet-derived growth factor receptor cDNA
1992
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β
1998
Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice
1998
Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells
1996
Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth
1997
Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4
1998 Standout
Topographic Mapping in Dorsoventral Axis of the Xenopus Retinotectal System Depends on Signaling through Ephrin-B Ligands
2002
FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.
1992
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
1997 StandoutScience
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA.
1993
Regulation of Neurotrophin-3 Expression by Epithelial-Mesenchymal Interactions: The Role of Wnt Factors
1999 StandoutScienceNobel
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
1999
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
Flk-1 expression defines a population of early embryonic hematopoietic precursors
1990
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
1999
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
Endothelial receptor tyrosine kinases involved in angiogenesis.
1995
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
Notch1 is essential for postimplantation development in mice.
1994
Isolating gene-corrected stem cells without drug selection
2005 StandoutNobel
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
1995 Standout
Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4
1992
Combinatorial patterns of somatic gene mutations in cancer
2008
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
2005 StandoutNobel
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
1994
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
1997 StandoutScience
The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.
1996
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
2000
Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.
1993
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.
1994
Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.
2001
flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors
1993
Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
1999
Understanding Adipocyte Differentiation
1998 Standout
Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.
1996
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
1999
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Neural Science
2000 StandoutNobel
Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.
1993
Maturation of Embryonic Stem Cells Into Endothelial Cells in an In Vitro Model of Vasculogenesis
1999
Modulation of VEGFR-2–mediated endothelial-cell activity by VEGF-C/VEGFR-3
2003
Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.
1993
Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo
1993
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Hematopoietic cytokines
2008
A requirement for neuropilin-1 in embryonic vessel formation
1999
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
2001
Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells [see comments]
1993
VEGF Receptor Signal Transduction
2001
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
1998
Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
2003
Cancer Genome Landscapes
2013 StandoutScience
The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of Kit
1997
Molecular Development of Sensory Maps
1999
Molecular Targets of Lithium Action
2001
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
1996
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Maturation of Embryonic Stem Cells Into Endothelial Cells in an In Vitro Model of Vasculogenesis
1999
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
2003
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
The splice variants of vascular endothelial growth factor (VEGF) and their receptors
2001
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
2000
Contribution of marrow-derived progenitors to vascular and cardiac regeneration
2002
Vascular endothelial growth factor (VEGF) and its receptors
1999 Standout
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Frequent Overexpression of Vascular Endothelial Growth Factor Gene in Human Renal Cell Carcinoma.
1994
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Works of William Matthews being referenced
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
1991
Lerk2 (Ephrin-B1) Is a Collapsing Factor for a Subset of Cortical Growth Cones and Acts by a Mechanism Different from AL-1 (Ephrin-A5)
1997
A role for leptin and its cognate receptor in hematopoiesis
1996
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
1991
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
2007 Standout
Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells
1994
Flt3high and Flt3low CD34+Progenitor Cells Isolated From Human Bone Marrow Are Functionally Distinct
1998
Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.
1995
A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells
1997
A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells
1997