Standout Papers
Citation Impact
Citing Papers
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
2005
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
The use of mRNA display to select high-affinity protein-binding peptides
2001 StandoutNobel
The Metal Binding Site of the Hepatitis C Virus NS3 Protease
1998
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
1998
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage
1998 StandoutNobel
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
2006
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Mechanism of autoproteolysis at the NS2–NS3 junction of the hepatitis C virus polyprotein
1998
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Changing the Structural Context of a Functional β-Hairpin
1996
Treatment triumphs
2014 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Functional proteins from a random-sequence library
2001 StandoutNatureNobel
Mechanisms of transformation by polyoma virus middle T antigen
1989
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism
1999
Identification of specific binding proteins for a nuclear location sequence
1989 Nature
Production of human antibodies using bacteriophage
1993
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
“Strong reasons make strong actions” — The antiviral efficacy of NS3/4A protease inhibitors†
2005
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors
1992 StandoutNobel
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
2003
Identification of biologically active peptides using random libraries displayed on phage
1995
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase
1999
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
Internal Processing of Hepatitis C Virus NS3 Protein
1999
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
2002
Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus
2005
In Vitro Characterization of a Purified NS2/3 Protease Variant of Hepatitis C Virus
2001
Structure and Function of the Hepatitis C Virus NS3-NS4A Serine Proteinase
2000
Molecular Determinants of TRIF Proteolysis Mediated by the Hepatitis C Virus NS3/4A Protease
2005
Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
2002
A conserved docking motif in MAP kinases common to substrates, activators and regulators
2000
Complex Formation of NS5B with NS3 and NS4A Proteins of Hepatitis C Virus
1998
Molecular Characterization of Hepatitis C Virus
1998 StandoutNobel
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
A phage display system for studying the sequence determinants of protein folding
1995 StandoutNobel
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form
1998
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase
1989 StandoutNobel
Binding of Different Divalent Cations to the Active Site of Avian Sarcoma Virus Integrase and Their Effects on Enzymatic Activity
1997
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
1991
Constrained peptide libraries as a tool for finding mimotopes
1994
Nopp 140 shuttles on tracks between nucleolus and cytoplasm
1992 StandoutNobel
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
2000
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
1995 StandoutNobel
A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
2006
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor
1998
Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain
1997
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
1995 StandoutNobel
Oncogenes and signal transduction
1991 Standout
Major nucleolar proteins shuttle between nucleus and cytoplasm
1989
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
1999
Protein–protein interaction through β-strand addition
2006
Scaffolds for engineering novel binding sites in proteins
1997
A novel recombinant single‐chain hepatitis C virus ns3‐ns4a protein with improved helicase activity
1999
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Structure of the hepatitis C virus RNA helicase domain
1997
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
From Structure to Function: New Insights into Hepatitis C Virus RNA Replication
2005
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
1990 Standout
Structural biology of hepatitis C virus
2004
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Random peptide libraries
1994
A class of membrane proteins with a C-terminal anchor
1993
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties
2000 StandoutNobel
Trypsin display on the surface of bacteriophage
1993
De novo proteins from designed combinatorial libraries
2004
In vitro selection from protein and peptide libraries
1994
Viral and cellular RNA helicases as antiviral targets
2005
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
The molecular virology of hepatitis C
1997
Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library
1992
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Synthetic human antibodies and a strategy for protein engineering
1998 StandoutNobel
Functional Organization of the Nuclear Envelope
1988
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
Regulation of Protein Kinases
2004
A strategy for the isolation of catalytic activities from repertoires of enzymes displayed on phage 1 1Edited by J. Karn
1999 StandoutNobel
Nuclear protein localization
1991
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Replication of hepatitis C virus
2007 StandoutNobel
A protein recognized by antibodies to Asp-Asp-Asp-Glu-Asp shows specific binding activity to heterogeneous nuclear transport signals.
1990
Role of the Nuclear Transport Factor p10 in Nuclear Import
1996 StandoutScienceNobel
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells
1990
Replication of hepatitis C virus
2000
The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6.
1994
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
RNA-peptide fusions for the in vitro selection of peptides and proteins
1997 StandoutNobel
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release
1995 StandoutScienceNobel
Evidence that the Middle T Antigen of Polyomavirus Interacts with the Membrane Skeleton
1993
The effect of protein context on nuclear location signal function
1987
Subcellular Localization, Stability, and trans -Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
2000 StandoutNobel
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
1997
Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen
1991
Biochemical and structural analysis of the NS5B RNA‐dependent RNA polymerase of the hepatitis C virus
2000
The Hepatitis C Virus NS3 Proteinase: Structure and Function of a Zinc-Containing Serine Proteinase
1998
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.
1990
Efficient Initiation of HCV RNA Replication in Cell Culture
2000 StandoutScienceNobel
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
2007 StandoutNobel
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
2008
An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase
1987
Studying Hepatitis C Virus: Making the Best of a Bad Virus
2007 StandoutNobel
Mutations That Affect Dimer Formation and Helicase Activity of the Hepatitis C Virus Helicase
2001 StandoutNobel
Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3′-Terminal Sequences of Viral Positive- and Negative-Strand RNA
2001
Making Antibodies by Phage Display Technology
1994 StandoutNobel
Identification and characterization of a nuclear localization sequence-binding protein in yeast.
1989
An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore.
1990
Mechanism of Activation of Complexed pp60 c-src by the Middle T Antigen of Polyomavirus
1989
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity
1990
Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires
1997
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
1997
Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
1998 StandoutNobel
Phage Display
1997
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
1987
Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
1999
A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein
1997
A yeast protein that binds nuclear localization signals: purification localization, and antibody inhibition of binding activity.
1991
STRUCTURAL AND MECHANISTIC DETERMINANTS OF AFFINITY AND SPECIFICITY OF LIGANDS DISCOVERED OR ENGINEERED BY PHAGE DISPLAY
1997
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
1997
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus.
1988
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Yeast proteins that recognize nuclear localization sequences.
1989
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
2003
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
1999
Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus
1998
Identification of four nuclear transport signal-binding proteins that interact with diverse transport signals.
1989
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
The NSR1 gene encodes a protein that specifically binds nuclear localization sequences and has two RNA recognition motifs.
1991
The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.
1988
Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system.
1992 StandoutNobel
The amino terminus of polyomavirus middle T antigen is required for transformation
1990
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
1997 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of William Markland being referenced
Mutations around the NG59 lesion indicate an active association of polyoma virus middle-T antigen with pp60c-src is required for cell transformation.
1986
Purification and characterization of the NS3 serine protease domain of hepatitis C virus expressed in Saccharomyces cerevisiae.
1997
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
1998
[4] Affinity maturation of proteins displayed on surface of M13 bacteriophage as major coat protein fusions
1996
Mutants of polyomavirus middle-T antigen
1987
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability
1990
Iterative Optimization of High-Affinity Protease Inhibitors Using Phage Display. 1. Plasmin
1996
Signal-Dependent Translocation of Simian Virus 40 Large-T Antigen into Rat Liver Nuclei in a Cell-Free System
1987
Iterative Optimization of High-Affinity Protease Inhibitors Using Phage Display. 2. Plasma Kallikrein and Thrombin
1996
Directed evolution of a protein: selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage.
1992
Mapping of the amino-terminal half of polyomavirus middle-T antigen indicates that this region is the binding domain for pp60c-src
1987
Design, construction and function of a multicopy display vector using fusions to the major coat protein of bacteriophage M13
1991
M13 bacteriophage displaying disulfide-constrained microproteins
1993
In vitro mutagenesis of the putative membrane-binding domain of polyomavirus middle-T antigen
1986
Site-directed mutagenesis of polyomavirus middle-T antigen sequences encoding tyrosine 315 and tyrosine 250
1986
Signal-dependent translocation of simian virus 40 large-T antigen into rat liver nuclei in a cell-free system.
1987