Standout Papers
Citation Impact
Citing Papers
Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.
1988
Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD
1989
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
1991
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
The open pore conformation of potassium channels
2002 StandoutNatureNobel
α‐Helical coiled coils and bundles: How to design an α‐helical protein
1990
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
1996
Predictive motifs derived from cytosine methyltransferases
1989 StandoutNobel
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain
1989
Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein
1989 Nature
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
1990
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
New light on Myc and Myb. Part I. Myc.
1990
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.
1991
Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun
1991 Standout
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif
1988
The role of the leucine zipper in the fos–jun interaction
1988 Nature
Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences
1993 StandoutNobel
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
1992
Induction of apoptosis in fibroblasts by c-myc protein
1992 Standout
The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein.
1989
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
1990
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
1991 Standout
The MYC protein activates transcription of the alpha-prothymosin gene.
1991 Nobel
An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters
1988
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
TFIIF-TAF-RNA polymerase II connection.
1994 StandoutNobel
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
1990 Standout
Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding
1990 StandoutNobel
A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein
1988 Nature
Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
1993
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
1993 Nature
Implications of the SNARE hypothesis for intracellular membrane topology and dynamics
1994 StandoutNobel
The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation
1989
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Molecular basis of transdifferentiation of pancreas to liver
2000
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs
1988 Nature
Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.
1994
DNA binding activities of three murine Jun proteins: Stimulation by Fos
1988 Nobel
Detection of a novel minisatellite-specific DNA-binding protein
1990
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
Determination of recognition-sequences for DNA-binding proteins by a polymerase chain reaction assisted binding site selection method (BSS) using nitrocellulose immobilized DNA binding protein
1992
Voltage gating of ion channels
1994
Effect of cell history on response to helix–loop–helix family of myogenic regulators
1990 Nature
Characterization of a Y-Box factor from Aplysia californica
1994
I-POU: a POU-domain protein that inhibits neuron-specific gene activation
1991 Nature
The principle of gating charge movement in a voltage-dependent K+ channel
2003 StandoutNatureNobel
SPXX, a frequent sequence motif in gene regulatory proteins
1989
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
1994
Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy
1990
daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex
1988
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
DNA recognition site analysis of Xenopus wingedhelix proteins
1995
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells
1988 Nature
Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
1990
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2000 StandoutNature
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
1996 Standout
A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
1988
A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 Å
1990 Nature
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
1994 Standout
RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
1991
The Design of Coiled-Coil Structures and Assemblies
2005
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
1988
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa
1994
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
1989 StandoutNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein.
1990
Characterization of a Cofactor That Regulates Dimerization of a Mammalian Homeodomain Protein
1991 Science
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.
1991
Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA
1988 Science
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.
1990
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
1988
Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers
1989 Science
Systematic Binding Analysis of the Insulin Gene Transcription Control Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators
1988
A Protein That Binds to a cis-acting Element of Wheat Histone Genes Has a Leucine Zipper Motif
1989 Science
Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins.
1992
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
1989
Transcriptional repression by a novel member of the bZIP family of transcription factors.
1992
cys-3, the Positive-Acting Sulfur Regulatory Gene ofNeurospora crassa, Encodes a Protein with a Putative Leucine Zipper DNA-Binding Element
1989
Transcription Factors, Normal Myeloid Development, and Leukemia
1997
The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.
1989
The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.
1991
PLANT DISEASE RESISTANCE GENES
1997 Standout
SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.
1994
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
1991
A recombinant cDNA derived from human brain encodes a DNA binding protein that stimulates transcription of the human neurotropic virus JCV
1991
Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc
1991 StandoutScience
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Myc oncoproteins are phosphorylated by casein kinase II.
1989
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.
1990
The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP).
1990
Different requirements for formation of Jun: Jun and Jun: Fos complexes.
1989
A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.
1990
Evidence That the Leucine Zipper Is a Coiled Coil
1989 Science
Structure of the human retinoblastoma gene.
1989
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
1992
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
1991 Standout
HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.
1989 StandoutNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ
1992 Science
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
1994 StandoutScienceNobel
Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons.
1990
Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.
1991
Predicting Coiled Coils from Protein Sequences
1991 StandoutScience
Differentiation requires continuous regulation.
1991 Nobel
Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.
1992
Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
1988
A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.
1989
Identification and Structure of Four Yeast Genes (SLY) That Are Able To Suppress the Functional Loss of YPT1, a Member of the RAS Superfamily
1991
CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
1991 Science
How fixed is the differentiated state?
1989
Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice.
1993
ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation
1993
Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun
1989 Science
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6
1992
Homoeo boxes, POU proteins and the limits to promiscuity
1988 Nature
MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer
1992
PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene
1995
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
1987 Standout
TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.
1991
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
A Field Guide to Foldamers
2001 Standout
Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.
1990
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
Characterization of the human lipoprotein lipase (LPL) promoter: evidence of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the differentiation-linked induction of the LPL gene during adipogenesis.
1992
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
1989
POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.
1991
Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1
1987 Science
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor
1991
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I
1991
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins
1989 Science
The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.
1990
Characterization of junD: a new member of the jun proto-oncogene family.
1989
The O2 gene which regulates zein deposition in maize endosperm encodes a protein with structural homologies to transcriptional activators.
1989
Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.
1992
Definition of the activities and properties of c-myc required to inhibit cell differentiation.
1990
Reciprocal Regulation of Adipogenesis by Myc and C/EBPα
1992 Science
cDNA-derived Amino Acid Sequence of the 86-kDa Subunit of the Ku Antigen
1989
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.
1991
The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.
1988 Nobel
v-maf, a viral oncogene that encodes a "leucine zipper" motif.
1989
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
1994 Standout
C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.
1993
Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen
1987
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.
1994
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
1998 StandoutNobel
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle
1994 StandoutNobel
Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice.
1990
Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements.
1991
Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.
1991
Combinatorial structure of a body muscle-specific transcriptional enhancer in Caenorhabditis elegans.
1994 StandoutNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Negative autoregulation of c-myc transcription.
1990
Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.
1992 Nobel
Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.
1992
Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions
1990 Science
Analysis of a Tissue-Specific Enhancer: ARF6 Regulates Adipogenic Gene Expression
1992
The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.
1988
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
1995
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
1989 Nature
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.
1988
Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators.
1988
Transcription Factors, Normal Myeloid Development, and Leukemia
1997
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.
1992
Works of William Landschulz being referenced
Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.
1989
Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.
1987
Isolation of a recombinant copy of the gene encoding C/EBP.
1988
Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.
1989
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
1988 StandoutScience
CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells.
1989
In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.
1988
The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite
1989 Science