Standout Papers
Citation Impact
Citing Papers
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
1998
Functional diversity of helper T lymphocytes
1996 StandoutNature
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
1996 Standout
GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression
1997
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Protein tyrosine kinase syk is associated with and activated by the il-2 receptor: Possible link with the c-myc induction pathway
1995
STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription
1996
Placental lactogen-I variant utilizes the prolactin receptor signaling pathway
1996
Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling
1995
Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
2000
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
1995
Oncogenic kinase signalling
2001 StandoutNature
Identification of a Stat Gene That Functions in Drosophila Development
1996
Jaks and Stats in signaling by the cytokine receptor superfamily
1995 Standout
Interleukin-12 and the regulation of innate resistance and adaptive immunity
2003 Standout
IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor
1995
Interleukin-12 Induces Expression of Interferon Regulatory Factor-1 via Signal Transducer and Activator of Transcription-4 in Human T Helper Type 1 Cells
1999
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism
1998
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Interaction between the Components of the Interferon γ Receptor Complex
1995
The paradigm of IL-6: from basic science to medicine.
2002
Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis
1998
The JAK-STAT pathway in Drosophila
1997
Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4
1996
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 Standout
Stat3 as an Oncogene
1999 Standout
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
1999
Reshaping human antibodies for therapy
1988 StandoutNatureNobel
Proline-rich Sequence-mediated Jak2 Association to the Prolactin Receptor Is Required but Not Sufficient for Signal Transduction
1995
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets
1998
Interleukin 6 and its Receptor: Ten Years Later
1998
CD28 costimulation is required not only to induce IL-12 receptor but also to render Janus kinases / STAT4 responsive to IL-12 stimulation in TCR-triggered T cells
2001
Regulation of Chemokine Expression by Antiinflammatory Cytokines
2002
Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation
1999
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
A family of cytokine-inducible inhibitors of signalling
1997 StandoutNature
Essential role of Stat6 in IL-4 signalling
1996 Nature
Dimerization of cell surface receptors in signal transduction
1995
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
1996
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
1995 Standout
Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses
1998 Standout
STATs in oncogenesis
2000 Standout
Type 1/Type 2 Immunity in Infectious Diseases
2001
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
1993
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
1998
Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction
1995
The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit
2000
Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons
1997
Dendritic cell regulation of TH1-TH2 development
2000
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
1995
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation
1995
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ
1996
Tyrosine Docking Sites of the Rat Prolactin Receptor Required for Association and Activation of Stat5
1997
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2
2000
STAT3 Forms Stable Homodimers in the Presence of Divalent Cations Prior to Activation
1998
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells
1999
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Activation of STAT proteins and growth control
2001
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation
1998
Participation of JAK and STAT Proteins in Growth Hormone-induced Signaling
1996
Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.
1994
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
1998
Prolactin signal transduction to milk protein genes: carboxy-terminal part of the prolactin receptor and its tyrosine phosphorylation are not obligatory for JAK2 and STAT5 activation
1997
Cancer-related inflammation
2008 StandoutNature
T lymphocyte differentiation in the periphery
1998
α and α Interferons and Their Receptor and Their Friends and Relations
1995
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
1997 Standout
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
1998 Standout
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
1994 StandoutNatureNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Cytokine receptor signalling
1995 Nature
The Jak-STAT pathway
2000
Activation of STAT Factors by Prolactin, Interferon-γ, Growth Hormones, and a Tyrosine Phosphatase Inhibitor in Rabbit Primary Mammary Epithelial Cells
1995
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
2002
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
1997
The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression
1996
Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy
1996
Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T H 1 Cells
1995 Science
Stoichiometric Structure-Function Analysis of the Prolactin Receptor Signaling Domain by Receptor Chimeras
1998
Analysis of the 3' flanking region of the human c-myc gene in lymphomas with the t(8;22) and t(2;8) chromosomal translocations
1986
Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.
1984
An appraisal of the application of recombinant DNA techniques to chromosome defects
1985
Activation Of Cellular Oncogenes in Hemopoietic Cells by Chromosome Translocation
1986
Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile
2000
Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y1007 in the Kinase Activation Loop
1997
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for plasmacytoma variant translocations
1985 Nature
1997
Cutting Edge: Ectopic Expression of the IL-12 Receptor-β2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-γ
2000
Cutting Edge: IL-12 and IL-18 Differentially Regulate the Transcriptional Activity of the Human IFN-γ Promoter in Primary CD4+ T Lymphocytes
1998
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
1997 Standout
STATs and Gene Regulation
1997 StandoutScience
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines
1995
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
1998 Standout
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.
1995
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
1995
Defective STAT signaling by the leptin receptor in diabetic mice.
1996
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-α/β on antigen cross-presentation
2006 StandoutNobel
Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation
1998
Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.
1995
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
1995 Science
Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells
1984 Nature
Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor
1996
Endocrine, paracrine and autocrine actions of prolactin on immune cells
1996
Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.
1984 StandoutNobel
Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1
2002
Expression of a translocated c-abl gene in hybrids of mouse fibroblasts and chronic myelogenous leukaemia cells
1986 Nature
Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis
1997
Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene.
1985
Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.
1985
Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins
1995 Science
Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase.
1996
An Interleukin-4-Induced Transcription Factor: IL-4 Stat
1994 Science
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.
1995
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
1999
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
1986
Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.
1986
Angiotensin II Activates pp60c-srcin Vascular Smooth Muscle Cells
1995
Variant (6 ; 15) translocation in a murine plasmacytoma occurs near an immunoglobulin κ gene but far from the myc oncogene
1984 Nature
Evolution of tumours and the impact of molecular oncology
1985 Nature
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.
1996
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
Chromatin structure around the c-myc gene in Burkitt lymphomas with upstream and downstream translocation points.
1985
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
1995
PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.
1996
Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region
2003
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription.
1983
Expression and Function of IL-12 and IL-18 Receptors on Human Tonsillar B Cells
2000
Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
1998
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.
1989 StandoutNobel
Jak-STAT Signaling Induced by the v- abl oncogene
1995 Science
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein
1995 StandoutScience
Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1
1995
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
1995
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
1998
Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain
1996 Science
Jak1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor
1997
Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.
1995
CELLULAR RESPONSES TO INTERFERON-γ
1997 Standout
Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits
1994 Science
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Efficient Recombination of a Switch Substrate Retrovector in CD40-Activated B Lymphocytes: Implications for the Control of CH Gene Switch Recombination
1998
Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells
1997
Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human Cγgenes
1986
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
1995
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability.
1985
DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.
1996
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2
1995
Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase
1997
A JAK1/JAK2 Chimera Can Sustain Alpha and Gamma Interferon Responses
1997
Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK
1995
Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases
1995 StandoutScience
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
1999
Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4+ Versus CD8+ T Cells
1999
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
1997
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
1994
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.
1994
A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia.
1984
Regulation of STAT‐dependent pathways by growth factors and cytokines
1996
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.
1995
Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos
1997 Nobel
Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G- CSF-mediated activation of signaling complexes of the p21ras route
1996
Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.
1996
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
1996
IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes.
1998
THE UBIQUITIN SYSTEM
1998 StandoutNobel
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
2001
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1
1996
IFN-α and IL-18 synergistically enhance IFN-γ production in human NK cells: differential regulation of Stat4 activation and IFN-γ gene expression by IFN-α and IL-12
2001
Generation of a Variant T(2;8) Translocation of Burkitt's Lymphoma by Site-Specific Recombination via the Kappa Light-Chain Joining Signals
1987
A human chromosome 8 region with abnormalities in B cell, HTLV-I+ T cell and c-myc amplified tumours.
1987
Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation
1984 Science
The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs
1998
THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
1997
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Naturally Occurring Dominant Negative Variants of Stat5
1996
JAK2 Is Required for Induction of the Murine DUB-1 Gene
1997
Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase
1996
The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.
1996
Works of William E. Thierfelder being referenced
Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor
1995 Nobel
Signaling by the cytokine receptor superfamily: JAKs and STATs
1994 Standout
Jaks and stats in cytokine signaling
1997
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response
1996
Stat4, a Novel Gamma Interferon Activation Site-Binding Protein Expressed in Early Myeloid Differentiation
1994
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
1994
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.
1983
Signaling by the Cytokine Receptor Superfamilya
1998
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis
1995