Standout Papers
Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis
2008 StandoutNobel
Receptor-Mediated Adenylyl Cyclase Activation Through XLαs, the Extra-Large Variant of the Stimulatory G Protein α-Subunit
2002
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
RGS-PX1, a GAP for Gα s and Sorting Nexin in Vesicular Trafficking
2001 Science
Induced Pluripotent Stem Cells Generated Without Viral Integration
2008 Science
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Basal cells as stem cells of the mouse trachea and human airway epithelium
2009
Oct4 and Klf4 Reprogram Dermal Papilla Cells into Induced Pluripotent Stem Cells
2009
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
2011
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
2001 StandoutNobel
Understanding pluripotency--how embryonic stem cells keep their options open
2008
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
2008
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
2005 Standout
MAP Kinase Stimulation by cAMP Does Not Require RAP1 but SRC Family Kinases
2002
Inflammation and cancer
2002 StandoutNature
Robust cellular reprogramming occurs spontaneously during liver regeneration
2013
Generation of Human Melanocytes from Induced Pluripotent Stem Cells
2011 StandoutNobel
Disease-Specific Induced Pluripotent Stem Cells
2008 Standout
Therapeutic modulation of Notch signalling — are we there yet?
2014
Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells
2009
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing
2005
Induced Pluripotent Stem Cells: Past, Present, and Future
2012 StandoutNobel
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
2009 Nature
Emerging interactions between skin stem cells and their niches
2014
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
2010
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
2006
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
2008
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
2008
Not so strange bedfellows: G-protein-coupled receptors and Src family kinases
2004
Wound repair and regeneration
2008 StandoutNature
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells
2009
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
2009
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Socializing with the Neighbors
2004 Standout
β2-Adrenergic Receptor Lacking the Cyclic AMP-Dependent Protein Kinase Consensus Sites Fully Activates Extracellular Signal-Regulated Kinase 1/2 in Human Embryonic Kidney 293 Cells: Lack of Evidence for Gs/Gi Switching.
2002
Cancer stem cells revisited
2017 Standout
Distinct Roles for Src Tyrosine Kinase in β2-Adrenergic Receptor Signaling to MAPK and in Receptor Internalization
2004
Unravelling stem cell dynamics by lineage tracing
2013
Genome Sequencing of Mouse Induced Pluripotent Stem Cells Reveals Retroelement Stability and Infrequent DNA Rearrangement during Reprogramming
2011
Recent advances in cancer stem cells
2008
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
2011
Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance
2010
Models, mechanisms and clinical evidence for cancer dormancy
2007
Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen
2004
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Transcriptional Signature and Memory Retention of Human-Induced Pluripotent Stem Cells
2009
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
2004
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
2007 Nature
Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells
2009
Corneal Epithelial Cell Fate Is Maintained during Repair by Notch1 Signaling via the Regulation of Vitamin A Metabolism
2007
Oct4-Induced Pluripotency in Adult Neural Stem Cells
2009
AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation
2001
Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
2005 Standout
Cellular plasticity: 1712 to the present day
2016
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Copy number variation and selection during reprogramming to pluripotency
2011 Nature
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
2008
A Drug-Inducible System for Direct Reprogramming of Human Somatic Cells to Pluripotency
2008
Keratinocyte–Fibroblast Interactions in Wound Healing
2007 Standout
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
2011
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
2008
Epidermal stem cells: practical perspectives and potential uses
2009
The intestinal stem cell
2008
Stem cells in tumor angiogenesis
2010
Induction of Pluripotent Stem Cells from Human Third Molar Mesenchymal Stromal Cells*
2010
Generation of human-induced pluripotent stem cells
2008
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Genetic and Epigenetic Variations in iPSCs: Potential Causes and Implications for Application
2013
PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1
2002
A single type of progenitor cell maintains normal epidermis
2007 Nature
Induced pluripotent stem cells from highly endangered species
2011
Induced pluripotent stem cells from a spinal muscular atrophy patient
2008 Nature
Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite Cell
2012
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race
2009
Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells
2008
A Fresh Look at iPS Cells
2009 StandoutNobel
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
2008
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
2007
Capturing and profiling adult hair follicle stem cells
2004 Standout
Distinct contribution of stem and progenitor cells to epidermal maintenance
2012 Nature
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
2008
Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver
2006
Genetic and epigenetic stability of human pluripotent stem cells
2012
Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis
2005
Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
2010 Standout
Persistent Donor Cell Gene Expression among Human Induced Pluripotent Stem Cells Contributes to Differences with Human Embryonic Stem Cells
2010
Seven-transmembrane receptors
2002 StandoutNobel
Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
2009 Standout
AT1 Receptor Mutant Lacking Heterotrimeric G Protein Coupling Activates the Src-Ras-ERK Pathway without Nuclear Translocation of ERKs
2002
Melanoma, Nevogenesis, and Stem Cell Biology
2008
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma
2014 Nature
A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells
2008
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
2010
Gingival Fibroblasts as a Promising Source of Induced Pluripotent Stem Cells
2010 StandoutNobel
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor
2002 StandoutNobel
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells
2006
Dissecting direct reprogramming through integrative genomic analysis
2008 Nature
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
2015 Nature
Signaling at zero G: G-protein-independent functions for 7-TM receptors
2001
Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome
2012
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR
2006 StandoutNobel
Low Incidence of DNA Sequence Variation in Human Induced Pluripotent Stem Cells Generated by Nonintegrating Plasmid Expression
2012
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Highly Efficient Generation of Human Hepatocyte–Like Cells From Induced Pluripotent Stem Cells
2009
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Determinants of Substrate Recognition in Nonreceptor Tyrosine Kinases
2003
Long-term renewal of hair follicles from clonogenic multipotent stem cells
2005
Stem cells: The growing pains of pluripotency
2011 Nature
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
2016
Dental Pulp Cells for Induced Pluripotent Stem Cell Banking
2010 StandoutNobel
Tumour stem cells and drug resistance
2005 Standout
Generation and Characterization of Human Induced Pluripotent Stem Cells
2009 StandoutNobel
Melanoma Stem Cells: The Dark Seed of Melanoma
2008
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals
2005
Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
2010
Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion
2006
Notch signaling controls germline stem cell niche formation in theDrosophilaovary
2007
Molecular characterization of melanocyte stem cells in their niche
2005
Derivation of induced pluripotent stem cells from pig somatic cells
2009
Csk Mediates G-Protein-Coupled Lysophosphatidic Acid Receptor-Induced Inhibition of Membrane-Bound Guanylyl Cyclase Activity
2006
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
2012 StandoutNobel
Heterogeneous Stem Cells in Skin Homeostatis and Wound Repair
2015
Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
2009
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Progress and Potential for Regenerative Medicine
2006
Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons
2005
Chemical Rescue of a Mutant Enzyme in Living Cells
2006 Science
Reprogramming of murine and human somatic cells using a single polycistronic vector
2008
Structure of the RGS-like Domain from PDZ-RhoGEF
2001
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue
2009 StandoutNobel
Current View: Intestinal Stem Cells and Signaling
2008
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
2010
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin
2006
De novo design of protein logic gates
2020 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of William E. Lowry being referenced
Generation of human induced pluripotent stem cells from dermal fibroblasts
2008
Defining the Epithelial Stem Cell Niche in Skin
2003 StandoutScience
Canonical notch signaling functions as a commitment switch in the epidermal lineage
2006
Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells
2010
Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation
2000
Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche
2004 Standout
Progress in understanding reprogramming to the induced pluripotent state
2011
Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells
2005
Female Human iPSCs Retain an Inactive X Chromosome
2010
Csk, a Critical Link of G Protein Signals to Actin Cytoskeletal Reorganization
2002
Role of the PHTH Module in Protein Substrate Recognition by Bruton's Agammaglobulinemia Tyrosine Kinase
2001
Copy Number Variant Analysis of Human Embryonic Stem Cells
2008
Derivation of Primordial Germ Cells from Human Embryonic and Induced Pluripotent Stem Cells Is Significantly Improved by Coculture with Human Fetal Gonadal Cells
2009
Defining the origins of Ras/p53-mediated squamous cell carcinoma
2011
Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons
2009
Src Tyrosine Kinase Is a Novel Direct Effector of G Proteins
2000