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Citing Papers
The role of creatine kinase in inhibition of mitochondrial permeability transition
1997
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
2005 StandoutScience
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Creatine: Biosynthesis, Regulation, and Function
1979
Chapter 8. Tissue acidosis in nociception and pain
1996
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Role of MgADP in the development of diastolic dysfunction in the intact beating rat heart.
1997
The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion,
1991
In situ study of myofibrils, mitochondria and bound creatine kinases in experimental cardiomyopathies
1994
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
The importance of the outer mitochondrial compartment in regulation of energy metabolism
1994
Sense and specificity: a molecular identity for nociceptors
1999 StandoutNobel
Uptake of creatine phosphate into heart mitochondria: a leak in the creatine shuttle
1997
Creatine accelerates the circadian clock in a unicellular alga
1988 Nature
Thyroid hormones and the creatine kinase system in cardiac cells
1994
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
2000 StandoutNature
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Creatine kinase: The reactive cysteine is required for synergism but is nonessential for catalysis
1993
Energy status of cells lacking dystrophin: an in vivo/in vitro study of mdx mouse skeletal muscle
1991
ATP synthesis kinetic properties of mitochondria isolated from the rat extensor digitorum longus muscle depleted of creatine with β-guanidinopropionic acid
1994
Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells
1996
Parathyroid hormone induction of creatine kinase activity and DNA synthesis is mimicked by phospholipase C, diacylglycerol and phorbol ester
1987
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Contractile properties and creatine kinase activity of myofilaments following ischemia and reperfusion of the rat heart
1987
Verapamil attenuates ATP depletion during hypoxia: 31P NMR studies of the isolated rat heart
1989
Sodium/calcium exchange modulates intracellular calcium overload during posthypoxic reoxygenation in mammalian working myocardium. Evidence from aequorin-loaded ferret ventricular muscles.
1994
Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity
1993
Calcium exchange in rabbit myocardium during and after hypoxia: Role of sodium-calcium exchange
1990
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase
1996
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Metabolic regulation ofin vivo myocardial contractile function: multiparameter analysis
1994
Na+ accumulation increases Ca2+ overload and impairs function in anoxic rat heart,
1990
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
1998 StandoutNobel
Metabolic and diagnostic significance of creatine kinase isoenzymes
1991
“Myocardial stunning”
1998
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Cellular energetics of dystrophic muscle
1993
In vivo phosphocreatine and ATP in piglet cerebral gray and white matter during seizures
1998
Rapid and irreversible inhibition of creatine kinase by peroxynitrite
1998
Cardiovascular Effects of Continuous Positive Airway Pressure in Patients with Heart Failure and Obstructive Sleep Apnea
2003
Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism
1992
Mitochondrial function in the oxygen depleted and reoxygenated myocardial cell
1994
Effects of γ-glutamylcysteine ethyl ester on heart mitochondrial creatine kinase activity: involvement of sulfhydryl groups
1998
Creatine Kinase Equilibration Follows Solution Thermodynamics in Skeletal Muscle.
1995
Variations of muscle mitochondrial creatine kinase activity in in mitochondrial diseases
1996
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Effect of creatine depletion on myocardial mechanics
1987
Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure
2001
Creatine metabolism and the consequences of creatine depletion in muscle
1994
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
The cardiac contractile failure induced by chronic creatine and phosphocreatine deficiency
1988
Intracellular alterations of the creatine kinase isoforms in brains of schizophrenic patients
1991
Quantitative evaluation of relationship between cardiac energy metabolism and post-ischemic recovery of contractile function
1989
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Modification of contractile proteins by oxygen free radicals in rat heart
1993
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure
2007
Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: The role of sarcomeric mitochondrial creatine kinase
1997
Creatine kinase in non-muscle tissues and cells
1994
Acid-sensing ion channels: advances, questions and therapeutic opportunities
2006
Creatine kinase, energy-rich phosphates and energy metabolism in heart muscle of different vertebrates
1994
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Alteration of the phosphocreatine energy shuttle components in diabetic rat heart
1991
The role of oxidants and free radicals in reperfusion injury
2006
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Atherosclerosis
2000 StandoutNature
Inhibition of creatine kinase by S‐nitrosoglutathione
1996
Protons: small stimulants of capsaicin-sensitive sensory nerves
1994
Myocardial protection during ischemia by prior feeding with the creatine analog: Cyclocreatine
1989
Decrease in heart mitochondrial creatine kinase activity due to oxygen free radicals
1992
Requirement of glycolytic substrate for metabolic recovery during moderate low flow ischemia
1995
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
2000 StandoutNature
Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain
1996
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Inhibition of glyceraldehyde-3-phosphate dehydrogenase in post-ischaemic myocardium
1996
Obstructive sleep apnoea and its cardiovascular consequences
2008 Standout
Protective activity of the spin trap tert-bytyl-α-phenyl nitrone (PBN) in reperfused rat heart
1992
Mitochondrial function in myocardial stunning
1991
Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia
2001 StandoutNobel
Mitochondrial creatine phosphokinase deficiency in diabetic rat heart
1988
Adaptation of cardiac contractile function to conditions of chronic energy deficiency
1989
Cardiac phosphocreatine deficiency induced by GPA during postnatal development in rat
1996
Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin
1993
Low mitochondrial proton leak due to high membrane cholesterol content and cytosolic creatine kinase as two features of the deviant bioenergetics of Ehrlich and AS30-D tumor cells.
1992
S-thiolation of cytoplasmic cardiac creatine kinase in heart cells treated with diamide
1987
In vivo 31P‐NMR studies of myocardial high energy phosphate metabolism during anoxia and recovery
1983
In situ study of myofibrils, mitochondria and bound creatine kinases in experimental cardiomyopathies
1994
The uptake of creatine by various tissues from a mouse bearing tumor cells
1984
Acid potentiation of the capsaicin receptor determined by a key extracellular site
2000 StandoutNobel
metabolic recovery after exercise and the assessment of mitochondrial function in Vivo in human skeletal muscle by means of 31P NMR
1984
Spatially resolved high resolution spectroscopy by “four-dimensional” NMR
1983
The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high-pressure liquid chromatographic studies of hamsters.
1987
Mathematical model of compartmentalized energy transfer: Its use for analysis and interpretation of 31P-NMR studies of isolated heart of creatine kinase deficient mice
1998
Metabolite channeling: A phosphorylcreatine shuttle to mediate high energy phosphate transport between sperm mitochondrion and tail
1985
Ischemic preconditioning preserves creatine phosphate and intracellular pH.
1991
Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M.
1988
Creatine Kinase System in Failing and Nonfailing Human Myocardium
1996
Spatial mapping of the chemical shift in NMR
1984
Effects of the anti-cancer drug adriamycin on the energy metabolism of rat heart as measured by in vivo 31P-NMR and implications for adriamycin-induced cardiotoxicity
1987
Evolution and Physiological Roles of Phosphagen Systems
2001
Expression of functional mitochondrial creatine kinase in liver of transgenic mice
1997
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
Phosphocreatine: Molecular and cellular aspects of the mechanism of cardioprotective action
1993
Post-infarction left ventricular remodeling induces changes in creatine kinase mRNA and protein subunit levels in porcine myocardium.
1997
Absence of myofibrillar creatine kinase and diaphragm isometric function during repetitive activation
1998
31P NMR studies of creatine kinase flux in M-creatine kinase-deficient mouse heart
1998
Compartmentation of multiple forms of creatine kinase in the distal nephron of the rat kidney.
1991
Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro
1992
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Pungent products from garlic activate the sensory ion channel TRPA1
2005 StandoutNobel
Accumulation of analgo of phosphocreatine in muscle of chicks fed 1-carboxymethyl-2-iminoimidazolidine (cyclocreatine).
1976
Electrical and mechanical activities of frog heart during energetic deficiency
1980
Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: A potential cause for altered energy transfer in cardiac muscle?
1998
Velocity of the creatine kinase reaction decreases in postischemic myocardium: a 31P-NMR magnetization transfer study of the isolated ferret heart.
1988
Decreased Energy Reserve in an Animal Model of Dilated Cardiomyopathy
1996
Actions of the creatine analogue β-guanidinopropionic acid on rat heart mitochondria
1994
Nuclear magnetic resonance. Potential applications in clinical cardiology
1984
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog
1997
Contractile failure and high-energy phosphate turnover during hypoxia: 31P-NMR surface coil studies in living rat.
1987
Nuclear Magnetic Resonance Technology for Medical Studies
1984 StandoutScienceNobel
Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: a potential cause for altered energy transfer in cardiac muscle?
1998
31P spectroscopic zeugmatography of phosphorus metabolites
1980 StandoutNobel
Regulation of energy flux through the creatine kinase reaction in vitro and in perfused rat heart
1984
Energy metabolism and mechanical recovery after cardioplegia in moderately hypertrophied rats
1998
A 31P-nuclear magnetic resonance study of skeletal muscle metabolism in rats depleted of creatine with the analogue β-guanidinopropionic acid
1984
Acid-Evoked Currents in Cardiac Sensory Neurons
1999
Alteration of the cytosolic-mitochondrial distribution of high-energy phosphates during global myocardial ischemia may contribute to early contractile failure.
1994
13C NMR Flux Ratio Analysis of Escherichia coli Central Carbon Metabolism in Microaerobic Bioprocesses
1999 StandoutNobel
Positron Tomography and Nuclear Magnetic Resonance Imaging
1982 StandoutScienceNobel
Quantitative 31P nuclear magnetic resonance analysis of metabolite concentrations in Langendorff-perfused rabbit hearts
1985
Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
1994
Energy metabolism of cardiac cell cultures during oxygen deprivation: effects of creatine and arachidonic acid
1985
Creatine kinase isoenzymes in spermatozoa
1986
Mitochondrial creatine kinase: a major constituent of pathological inclusions seen in mitochondrial myopathies.
1994
Estrogen-induced changes in high-energy phosphate metabolism in rat uterus: phosphorus-31 NMR studies
1984
Adenylate kinase: Kinetic behavior in intact cells indicates it is integral to multiple cellular processes
1998
The effect of inorganic phosphate on creatine kinase in respiring rat heart mitochondria
1984
Rapid disassembly of cold-stable microtubules by calmodulin.
1981 StandoutNobel
Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia-Reperfusion Injury
2003 StandoutNobel
Creatine kinase kinetics, ATP turnover, and cardiac performance in hearts depleted of creatine with the substrate analogue β-guanidinopropionic acid
1985
Increased mitochondrial creatine kinase in chronically stimulated fast‐twitch rabbit muscle
1985
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve.
1996
Creatine Kinase Is the Main Target of Reactive Oxygen Species in Cardiac Myofibrils
1996
Disruption of myofibrillar energy use: dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium.
1987
Occurrence of free creatine, phosphocreatine and creatine phosphokinase in adipose tissue
1976
Postanoxic recovery of spontaneously beating isolated atria: pH related role of adenylate kinase
1986
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
2000
Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation
1999
High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in photoreceptor cells.
1986
Cellular Applications of 31 P and 13 C Nuclear Magnetic Resonance
1979 Science
A sensory neuron-specific, proton-gated ion channel
1998
Proton correlation nuclear magnetic resonance study of metabolic regulations and pyruvate transport in anaerobic Escherichia coli cells
1980
Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons.
1996
Relations among sodium pump inhibition, Na-Ca and Na-H exchange activities, and Ca-H interaction in cultured chick heart cells.
1987
Impaired energy metabolism in skeletal muscle during phosphate depletion
1983
Overexpression of human copper,zinc-superoxide dismutase (SOD1) prevents postischemic injury
1998
Mapping of metabolites in whole animals by 31P NMR using surface coils
1980 Nature
Changes in creatine kinase M localization in acute ischemic myocardial cells. Immunoelectron microscopic studies.
1993
Calcium binding properties of beef cardiac troponin.
1978
Energy metabolism and mechanical recovery after cardioplegia in moderately hypertrophiedrats
1998
Enhanced sensitivity to hypoxia-induced diastolic dysfunction in pressure-overload left ventricular hypertrophy in the rat: role of high-energy phosphate depletion.
1988
Sodium/Calcium Exchange: Its Physiological Implications
1999 Standout
Preservation of phosphagen kinase function during transient hypoxia via enzyme abundance or resistance to oxidative inactivation
1996
Adenylate kinase: Kinetic behavior in intact cells indicates it is integral to multiple cellular processes
1998
Creatine Kinase Gene Mutation in a Patient with Muscle Creatine Kinase Deficiency
2001 StandoutNobel
Protons activate a cation conductance in a sub‐population of rat dorsal root ganglion neurones.
1991
Creatine and Creatinine Metabolism
2000 Standout
Assessment of Pharmacological Treatment of Myocardial Infarction by Phosphorus-31 NMR with Surface Coils
1981 Science
Enalapril Treatment Increases Cardiac Performance and Energy Reserve Via the Creatine Kinase Reaction in Myocardium of Syrian Myopathic Hamsters With Advanced Heart Failure
1995
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
The relationship between global myocardial ischemia, left ventricular function, myocardial redox state, and high energy phosphate profile. A phosphorous-31 nuclear magnetic resonance study
1983
Effects of Continuous Positive Airway Pressure on Obstructive Sleep Apnea and Left Ventricular Afterload in Patients With Heart Failure
1998
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the ‘phosphocreatine circuit’ for cellular energy homeostasis
1992 Standout
Creatine Kinase: Structure‐Activity Relationships
1983
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.
1980
Works of William E. Jacobus being referenced
Heart creatine kinase : the integration of isozymes for energy distribution
1980
Absence of Acute Doxorubicin-Induced Dysfunction of Heart Mitochondrial Oxidative Phosphorylation and Creatine Kinase Activities
1988
Preserved high energy phosphate metabolic reserve in globally “stunned” hearts despite reduction of basal ATP content and contractility+
1987
The Functional Recovery of Post-Ischemic Myocardium Requires Glycolysis During Early Reperfusion
1993
Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.
1987
Detection of regional ischemia in perfused beating hearts by phosphorus nuclear magnetic resonance
1977
A phosphorus-31 nuclear magnetic resonance study of the metabolic, contractile, and ionic consequences of induced calcium alterations in the isovolumic rat heart.
1986
Creatine kinase of heart mitochondria. Control of oxidative phosphorylation by the extramitochondrial concentrations of creatine and phosphocreatine.
1986
Substrate induced alterations of cardiac energy metabolism and contractility
1986
Perfusate sodium during ischemia modifies post-ischemic functional and metabolic recovery in the rabbit heart*
1984
Mass spectrometry and phosphorus-31 nuclear magnetic resonance demonstrate additive myocardial protection by potassium cardioplegia and hypothermia during global ischemia.
1980
A 31P NUCLEAR MAGNETIC RESONANCE STUDY
1988
Phosphorus nuclear magnetic resonance of perfused working rat hearts
1977 Nature
Phosphorus nuclear magnetic resonance studies of heart physiology
1978
Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow.
1987
Intracellular acidosis and contractility in the normal and ischemic heart as examined by 31P NMR*1
1982
Bioenergetic consequences of cardiac phosphocreatine depletion induced by creatine analogue feeding.
1991
Tight coupling of intracellular pH and ventricular performance
1978
Creatine Kinase of Rat Heart Mitochondria
1973
Mechanisms of ischemic myocardial cell damage assessed by phosphorus-31 nuclear magnetic resonance.
1982
Creatine kinase of heart mitochondria. Functional coupling of ADP transfer to the adenine nucleotide translocase.
1982
Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts
1995
Evidence against direct transfer of the adenine nucleotides by the heart mitochondrial creatine kinaseadenine nucleotide translocase complex
1982
Theoretical support for the heart phosphocreatine energy transport shuttle based on the intracellular diffusion limited mobility of ADP
1985
Maintenance of aerobic metabolism during global ischemia with perfluorocarbon cardioplegia improves myocardial preservation.
1984
Creatine kinase of rat heart mitochondria. The demonstration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation.
1985
Mitochondrial respiratory control. Evidence against the regulation of respiration by extramitochondrial phosphorylation potentials or by [ATP]/[ADP] ratios.
1982
Specific enhancement of the cardiac myofibrillar ATPase by bound creatine kinase.
1992
Respiratory Control and the Integration of Heart High-Energy Phosphate Metabolism by Mitochondrial Creatine Kinase
1985
Creatine kinase of heart mitochondria. The progressive loss of enzyme activity during in vivo ischemia and its correlation to depressed myocardial function.
1985
CONTROL OF HEART OXIDATIVE PHOSPHORYLATION BY CREATINE KINASE IN MITOCHONDRIAL MEMBRANES*
1983
Studies of energy transport in heart cells. The importance of creatine kinase localization for the coupling of mitochondrial phosphorylcreatine production to oxidative phosphorylation.
1980
Creatine kinase of heart mitochondria: Changes in its kinetic properties induced by coupling to oxidative phosphorylation
1982
Mechanism of early contractile failure during hypoxia in intact ferret heart: evidence for modulation of maximal Ca2+-activated force by inorganic phosphate.
1986
Acute Doxorubicin Cardiotoxicity
1986
Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic "stunned" myocardium.
1989
Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury.
1987
Effects of ATP precursors on ATP and free ADP content and functional recovery of postischemic hearts
1989