Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Regulation of Muscarinic Acetylcholine Receptor Sequestration and Function by β-Arrestin
1999
β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6
2004 StandoutNobel
Regulation of Human Chemokine Receptors CXCR4
1997
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Feedback Regulation of β-Arrestin1 Function by Extracellular Signal-regulated Kinases
1999 StandoutNobel
Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling
1999 StandoutNobel
Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization
1999
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
A Dominant Negative Mutant of the G Protein-Coupled Receptor Kinase 2 Selectively Attenuates Adenosine A2 Receptor Desensitization
1997
Differential Roles of Arrestin-2 Interaction with Clathrin and Adaptor Protein 2 in G Protein-coupled Receptor Trafficking
2002
Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors
2001 StandoutNobel
β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization
2002
Extent and character of circadian gene expression in Drosophila melanogaster: identification of twenty oscillating mRNAs in the fly head
1995
Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1
1997 StandoutNobel
The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versusRecycling
1999
Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization
1996
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 Standout
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Adrenergic Receptors From Molecular Structure to in vivo function
1997 StandoutNobel
μ and δ Opioid Receptors Are Differentially Desensitized by the Coexpression of β-Adrenergic Receptor Kinase 2 and β-Arrestin 2 in Xenopus Oocytes
1997
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors
2000
The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits
2000
β-Adrenergic Receptor Kinase (GRK2) Colocalizes with β-Adrenergic Receptors during Agonist-induced Receptor Internalization
1997
Ubiquitination of β-Arrestin Links Seven-transmembrane Receptor Endocytosis and ERK Activation
2007 StandoutNobel
Regulation of tyrosine kinase activation and granule release through β-arrestin by CXCR1
2000
Engineering allostery
2014
Internalization of the m2 Muscarinic Acetylcholine Receptor
1997
Arrestin/Clathrin Interaction
1997
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
RNA Editing Induces Variation in Desensitization and Trafficking of 5-Hydroxytryptamine 2c Receptor Isoforms
2004
Gravin-mediated Formation of Signaling Complexes in β2-Adrenergic Receptor Desensitization and Resensitization
2000
Trafficking of the HIV Coreceptor CXCR4
1999
G Protein-coupled Receptor Kinase 2/Gαq/11 Interaction
2003
Localization of the Sites Mediating Desensitization of the β2-Adrenergic Receptor by the GRK Pathway
2000
Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor
1998
The Akt–GSK-3 signaling cascade in the actions of dopamine
2007
β-Arrestin 2 Functions as a G-Protein-coupled Receptor-activated Regulator of Oncoprotein Mdm2
2003
Identification of NSF as a β-Arrestin1-binding Protein
1999 StandoutNobel
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase
1998 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
A Central Role for -Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in 2-Adrenergic Receptor Resensitization
1997
β-Arrestin1 Interacts with the Catalytic Domain of the Tyrosine Kinase c-SRC
2000 StandoutNobel
Agonist-Receptor-Arrestin, an Alternative Ternary Complex with High Agonist Affinity
1997
Modulation of the Arrestin-Clathrin Interaction in Cells
1997
Role of the Thrombin Receptor's Cytoplasmic Tail in Intracellular Trafficking
1996
α-Thrombin Induces Rapid and Sustained Akt Phosphorylation by β-Arrestin1-dependent and -independent Mechanisms, and Only the Sustained Akt Phosphorylation Is Essential for G1 Phase Progression
2002
Cellular Trafficking of G Protein-coupled Receptor/β-Arrestin Endocytic Complexes
1999
Role of β-Arrestins in the IntracelIular Trafficking of G-Protein-Coupled Receptors
1997
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin
1998 StandoutNobel
Role of Clathrin-mediated Endocytosis in CXCR2 Sequestration, Resensitization, and Signal Transduction
1999
De novo design of bioactive protein switches
2019 StandoutNatureNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Protease-activated Receptor-1 Down-regulation
2000
Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis*
2001
β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor
1996 Nature
The Role of Sequestration in G Protein-coupled Receptor Resensitization
1997 StandoutNobel
Endocytosis and recycling of G protein-coupled receptors
1997
A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation
1997
β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor
1998 StandoutNobel
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor
1997
Internal Trafficking and Surface Mobility of a Functionally Intact β2-Adrenergic Receptor-Green Fluorescent Protein Conjugate
1997
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
2001 StandoutNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
G Protein-coupled Receptors
1998 StandoutNobel
Phosphorylation-independent β-Arrestin Translocation and Internalization of Leukotriene B4 Receptors
2004
Agonist-dependent Recruitment of Phosphoinositide 3-Kinase to the Membrane by β-Adrenergic Receptor Kinase 1
2001
β-Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation
2002 StandoutNobel
Arrestin/Clathrin Interaction
1997
Targeted Construction of Phosphorylation-independent β-Arrestin Mutants with Constitutive Activity in Cells
1999
Differential Regulation of the Dopamine D2and D3 Receptors by G Protein-coupled Receptor Kinases and β-Arrestins
2001
RGS Proteins and Signaling by Heterotrimeric G Proteins
1997
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Clathrin Box in G Protein-coupled Receptor Kinase 2
2001
Arresting developments in heptahelical receptor signaling and regulation
2002 StandoutNobel
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001 StandoutNobel
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
1996
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
The Formation of Stable Rhodopsin-Arrestin Complexes Induces Apoptosis and Photoreceptor Cell Degeneration
2000
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Regulation of Receptor Trafficking by GRKs and Arrestins
2006
A dileucine motif in the C terminus of the β 2 -adrenergic receptor is involved in receptor internalization
1997
Independent Photoreceptive Circadian Clocks Throughout Drosophila
1997 StandoutScienceNobel
Adaptors for Clathrin-Mediated Traffic
1999
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Essential role of β-adrenergic receptor kinase 1 in cardiac development and function
1996 StandoutNobel
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity
2000 StandoutNobel
ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway
2004 Science
beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001
DESENSITIZATION OF G-PROTEIN–COUPLED RECEPTORS IN THE CARDIOVASCULAR SYSTEM
1999
Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization
1997 StandoutNobel
Detection of β 2 -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
2000
CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING: An Integrated Process
1997
Insulin Induces Heterologous Desensitization of G Protein-Coupled Receptor and Insulin-Like Growth Factor I Signaling by Downregulating β-Arrestin-1
2002
Iron-Sulfur Clusters: Nature's Modular, Multipurpose Structures
1997 StandoutScience
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
2003 StandoutNobel
Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.
1992
The β 2 -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
1999
β-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53
2007
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
2004 StandoutNobel
β-Arrestin1 Knockout Mice Appear Normal but Demonstrate Altered Cardiac Responses to β-Adrenergic Stimulation
1997
Endocytosis and recycling of G protein-coupled receptors
1997
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
Phosphorylation-Independent Desensitization of G Protein-Coupled Receptors?
2002
Decreased expression and activity of G‐protein‐coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis
1999
Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting
1998
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
1998
Works of William E. Downey being referenced
Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial
2008
An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein
1992
A regulated RNA binding protein also possesses aconitase activity.
1991
Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization
1996 Science