Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
2015
CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation
1999 StandoutNobel
The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival
1999
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
2001 Nature
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation
1995
The role of the graft in establishing tolerance
2002
NONDEPLETING ANTI-CD4 MONOCLONAL ANTIBODY ENHANCES THE ABILITY OF ORAL ALLOANTIGEN DELIVERY TO INDUCE INDEFINITE SURVIVAL OF CARDIAC ALLOGRAFTS: ORAL TOLERANCE TO ALLOANTIGEN1
2000
Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation
1993
Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses
1995
Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): Analysis by site directed mutagenesis
1996
Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling
1994 Nature
T cell co-stimulation and in vivo tolerance
1993
Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
1995
Signal transduction events leading to T-cell lymphokine gene expression
1993
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
1995
B70 antigen is a second ligand for CTLA-4 and CD28
1993 Nature
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis
1997 StandoutNobel
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig
2003
A negative regulatory function of B7 revealed in B7-1 transgenic mice
1994
Inhibition of CD28‐mediated T cell costimulation by the phosphoinositide 3‐kinase inhibitor wortmannin
1995
Co-stimulation in T cell responses
1997 StandoutNobel
CTLA-4: new insights into its biological function and use in tumor immunotherapy
2002 StandoutNobel
Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement
1996
CTLA-4 Regulates Induction of Anergy In Vivo
2001
Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin
1995
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
2000
CD28-B7 interactions in T-cell activation
1994 StandoutNobel
Isolation and Function of Human Dendritic Cells
1994
Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
2011 StandoutNobel
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
1992 StandoutNatureNobel
Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor‐transgenic CTLA‐4‐deficient mice
1997
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Absence of B7-dependent responses in CD28-deficient mice
1994
Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice
1995
The Interaction Properties of Costimulatory Molecules Revisited
2002
Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
1996
Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells
1996
Signals and signs for lymphocyte responses
1994
Follicular B helper T cells in antibody responses and autoimmunity
2005
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
1999
Structural mechanisms of costimulation
2002
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
1999 Nature
Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function
1996
The Emerging Role of CTLA-4 as an Immune Attenuator
1997 StandoutNobel
Lymphocyte responses and cytokines
1994 Standout
Structure and Dimerization of a Soluble Form of B7-1
2000
How B and T cells talk to each other
1994 Nature
T Cell–Mediated Elimination of B7.2 Transgenic B Cells
1997 StandoutNobel
The immunological synapse and CD28-CD80 interactions
2001
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
1999 Standout
The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.
1992 StandoutNobel
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
1988 Nature
Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.
1994 StandoutNobel
T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras
1995
CTLA-4 can function as a negative regulator of T cell activation
1994 Standout
CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca2+‐independent costimulatory activity
1994
Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
1992
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
Indirect presentation of MHC antigens in transplantation
1994
Regulatory T cells in transplantation tolerance
2003 StandoutNobel
CTLA‐4, a Negative Regulator of T‐Lymphocyte Activation
1996
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
1995 Standout
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Signals arising from antigen-presenting cells
1991
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
2002 Standout
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
1992 StandoutNatureNobel
Costimulation Blockade with Belatacept in Renal Transplantation
2005 Standout
The Role of the CD28 Receptor During T Cell Responses to Antigen
1993
The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses
1996 StandoutNobel
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
1996 Nature
The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection
1994
CTLA-4–Ig regulates tryptophan catabolism in vivo
2002
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation
1995
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
2006 StandoutNobel
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Costimulation of T cells for tumor immunity
1993
Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway
1991
Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement
1997
What's the difference between CD80 and CD86?
2003
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
1999
CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis
2000
B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα
1999
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection
1998
Transgenic Mice and Analysis of B-Cell Tolerance
1992
Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2
1997
A novel mechanism of glucocorticoid-induced immune suppression: the inhibiton of T cell-mediated terminal maturation of a murine dendritic cell line.
1996
Tyrosine Phosphatase SHP-2 Binding to CTLA-4: Absence of Direct YVKM/YFIP Motif Recognition
2000
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation
1997
Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.
1995
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
1995
Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail
1995
The B7 and CD28 receptor families
1994
The B7–CD28 superfamily
2002
Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
2009
New perspectives of C1328-137-mediated T cell costimulation
1995
Rational Development of LEA29Y (belatacept), a High-Affinity Variant of CTLA4-Ig with Potent Immunosuppressive Properties
2005
Covalent Dimerization of CD28/CTLA-4 and Oligomerization of CD80/CD86 Regulate T Cell Costimulatory Interactions
1996
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
1996 StandoutNobel
Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation
1998
Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells
2005
Involvement of CD40 Ligand-CD40 and CTLA4-B7 Pathways in Murine Acute Graft-Versus-Host Disease Induced by Allogeneic T Cells Lacking CD28
1998
Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells
1998
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.
1991
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)
1999
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase
1994
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.
1992 Nobel
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.
1996
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
1994
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
2009 Standout
Induction of antigen-specific T cell anergy: An early event in the course of tumor progression
1998
A reassessment of the role of B7-1 expression in tumor rejection.
1995
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
1992
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection
2003
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.
1994
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
1992
Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.
1994
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
1994
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
Expression and functional significance of an additional ligand for CTLA-4.
1993
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
1996
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
1997
B7 Interactions with CD28 and CTLA-4 Control Tolerance or Induction of Mucosal Inflammation in Chronic Experimental Colitis
2001
Manipulation of costimulatory signals to enhance antitumor T-cell responses
1995 StandoutNobel
B7–CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge
1998
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.
1995
The role of the graft in establishing tolerance
2002
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
1992
CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.
1993 StandoutNobel
CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion
1997
Absence of CTLA-4 Lowers the Activation Threshold of Primed CD8+ TCR-Transgenic T Cells: Lack of Correlation with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase
2001
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis
1999 Nobel
Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.
1992
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
1995 StandoutNobel
CTLA4 mediates antigen-specific apoptosis of human T cells.
1995
CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression
2000
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation
1995
Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.
1996
Regulation of Cell Surface Expression of CTLA-4 by Secretion of CTLA-4-Containing Lysosomes Upon Activation of CD4+ T Cells
2000
Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.
1993 StandoutNobel
A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade
2000
Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of Thymocytes
1998
Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70
1997
THE B7 FAMILY REVISITED
2005 Standout
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule
1992 Science
Structural Analysis of CTLA-4 Function In Vivo
2000
INDUCTION OF TH1 AND TH2 CD4+T CELL RESPONSES:The Alternative Approaches
1997
Cellular and molecular characterization of the scurfy mouse mutant.
1999 StandoutNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
2000 StandoutNobel
CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.
1992
Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells
2000
CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.
1994
CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1
1992
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
2001
Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.
1994
Induction of T Cell Anergy in the Absence of CTLA-4/B7 Interaction
2000
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.
1994
Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice
1993 Science
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling
2003
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Cellular and Molecular Characterization of the scurfy Mouse Mutant
1999 StandoutNobel
CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells
2004
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.
1992
Prognostic Factors Related to Clinical Response in Patients with Metastatic Melanoma Treated by CTL-Associated Antigen-4 Blockade
2007
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
CTLA-4 ligation blocks CD28-dependent T cell activation.
1996
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
Alloantigen–induced specific immunological unresponsiveness
2001
Functional expression of B7/BB1 on activated T lymphocytes.
1993
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
1995
A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.
1993
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen
1994
Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.
1992 Nobel
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.
1994 StandoutNobel
CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation
1995
Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani
1998
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Requirement for natural killer T (NKT) cells in the induction of allograft tolerance
2001
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 StandoutNobel
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
1997
Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.
1994
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire
2012
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
2001
Fas-independent death of activated CD4+T lymphocytes induced by CTLA-4 crosslinking
1998
Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation
1993 Science
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
1997 StandoutNobel
Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.
1993
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
1995
Structure of Murine CTLA-4 and Its Role in Modulating T Cell Responsiveness
2000 Science
Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?
1995
CTLA-4: a negative regulator of autoimmune disease.
1996
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor.
1993
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.
1994
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.
1994
Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.
1992
Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjögren’s syndrome (SS) through up-regulated Th2 response
2000
Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4
2000
Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.
1993
Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?
1998
Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail
1999
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance
2001
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
1993 Science
B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28
1998
Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.
1994
Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.
1993 StandoutNobel
Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation
1999 StandoutNobel
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
1993
Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation
1993 Science
Works of William Brady being referenced
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
1992
Binding Stoichiometry of the Cytotoxic T Lymphocyte-associated Molecule-4 (CTLA-4)
1995
Phorbol-12-Myristate-13-Acetate-Treated Human Keratinocytes Express B7-Like Molecules That Serve a Costimulatory Role in T-Cell Activation
1993
Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen
1992
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
1994
Characterization of Human Inducible Costimulator Ligand Expression and Function
2000
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
1992
Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.
1994
Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.
1993
Expression and function of B7 on human epidermal Langerhans cells
1993
Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
1986
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
1991
CTLA-4 is a second receptor for the B cell activation antigen B7.
1991
Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg
1992 StandoutScience