Citation Impact
Citing Papers
A Bifunctional Bacterial Protein Links GDI Displacement to Rab1 Activation
2007 Science
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
2009 Standout
Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
2006 Science
Hallmarks of Cancer: The Next Generation
2011 Standout
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.
1992
Host Cell Autophagy Is Induced by Toxoplasma gondii and Contributes to Parasite Growth
2008
Structure and mutational analysis of Rab GDP-dissociation inhibitor
1996 Nature
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
1993
Small GTP-Binding Proteins
1992
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation
2008 Nature
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
1993 StandoutNobel
Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy
2008
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
2007
The 2.0 Å crystal structure of a heterotrimeric G protein
1996 Nature
Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1
1997
The Interferon-Inducible Protein Viperin Inhibits Influenza Virus Release by Perturbing Lipid Rafts
2007
Deletion of Autophagy-related 5 (Atg5) and Pik3c3 Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation
2013
Dynamic control of neuroexocytosis by phosphoinositides in health and disease
2010
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Evolution of the rab family of small GTP-binding proteins
2001
Steady-state kinetic mechanism of ras farnesyl:protein transferase
1992
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Regulation and role of autophagy in mammalian cells
2004
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
Rab GTPases in vesicular transport
1993
Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor
1995
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles
1994 StandoutNobel
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
2009
Dependence of Ypt1 and Sec4 membrane attachment on Bet2
1991 Nature
Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia
1995
Structural insights into the function of the Rab GDI superfamily
1996
Rab GTPases as coordinators of vesicle traffic
2009 Standout
Innate and Adaptive Immunity through Autophagy
2007
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
The diversity of Rab proteins in vesicle transport
1997
Prenyl proteins in eukaryotic cells: a new type of membrane anchor
1990
Role of Protein Modification Reactions in Programming Interactions Between Ras-Related GTPases and Cell Membranes
1994
Mechanism of Digeranylgeranylation of Rab Proteins
1996
All ras proteins are polyisoprenylated but only some are palmitoylated
1989 Standout
Autophagosome formation: core machinery and adaptations
2007 Standout
Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit
1991 Nobel
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
1994
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
2007
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Human immunodeficiency virus type-1 infection inhibits autophagy
2008
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Prenylation of Rho1p Is Required for Activation of Yeast 1,3-β-Glucan Synthase
1999
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Nucleotide Dependence of Rab Geranylgeranylation
1996
Evidence for a Ras/Ral signaling cascade
1996
Protein Prenyltransferases
1996
Membrane Fusion
2003 StandoutNobel
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Heterotrimeric G proteins
1996
Regulation of the mevalonate pathway
1990 StandoutNature
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
Methods in Mammalian Autophagy Research
2010 Standout
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product
1992 StandoutNobel
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007
Autophagy as an immune defense mechanism
2006
Role of Rab GTPases in Membrane Traffic
1997
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
2000
Ras C-terminal processing enzymes—New drug targets?
1991
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
2008
Autophagic cell death: the story of a misnomer
2008
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
The autophagic response to nutrient deprivation in the hl‐1 cardiac myocyte is modulated by Bcl‐2 and sarco/endoplasmic reticulum calcium stores
2007
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Autophagy: process and function
2007 Standout
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
2008
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides
1990 Nobel
G protein—coupled receptor kinases
1993 StandoutNobel
Involvement of autophagy in viral infections: antiviral function and subversion by viruses
2007
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
The emerging shape of the ESCRT machinery
2007
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
The autophagy effector Beclin 1: a novel BH3-only protein
2008
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.
1990
Sequence dependence of protein isoprenylation
1991
Evidence for modification of lamin B by a product of mevalonic acid.
1988
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Identification of Geranylgeranyl-Modified Proteins in HeLa Cells
1990 Science
Small GTP-Binding Proteins
2001 Standout
Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase.
1988
The gamma subunit of transducin is farnesylated.
1990
Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast.
1994
Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.
1996
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
1994 Nobel
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
2008
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
2006
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.
1992 StandoutNobel
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.
1990
The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.
1991
A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.
1991
Isoprenoid modification of rab proteins terminating in CC or CXC motifs.
1991
Human Lamin B Contains a Farnesylated Cysteine Residue
1989
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
2008
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
1996
A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments.
1994
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.
1991
Analysis of prenylated carboxyl-terminal cysteine methyl esters in proteins
1990
G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.
1991
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Isoprenylation of rab proteins on structurally distinct cysteine motifs
1992
Growth Factors and Cancer
1991 StandoutScience
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Rab GTPases at a glance
2007
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
1992
Diversity of Signaling Controls of Macroautophagy in Mammalian Cells.
2002
Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.
1988
p21ras is modified by a farnesyl isoprenoid.
1989
Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase
1993 ScienceNobel
Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.
1992
Identification of a novel Rac1-interacting protein involved in membrane ruffling.
1996
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
Prenylated Proteins: the Structure of the Isoprenoid Group
1990 Science
THE UBIQUITIN SYSTEM
1998 StandoutNobel
An Arabidopsis Homolog of YeastATG6/VPS30Is Essential for Pollen Germination
2007 StandoutNobel
Lipid modifications of G proteins: alpha subunits are palmitoylated.
1993 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.
1992
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
1992 StandoutNobel
G protein gamma subunits contain a 20-carbon isoprenoid.
1990 StandoutNobel
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.
1993
rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.
1990 StandoutNobel
Works of William A. Maltese being referenced
Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis
2008
Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation
1987
Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells
2003
Rab24 Is an Atypical Member of the Rab GTPase Family
2000
Retention of the Alzheimer's Amyloid Precursor Fragment C99 in the Endoplasmic Reticulum Prevents Formation of Amyloid β-Peptide
2001
Association of Rab1B with GDP-dissociation Inhibitor (GDI) Is Required for Recycling but Not Initial Membrane Targeting of the Rab Protein
1996
Regions Outside of the CAAX Motif Influence the Specificity of Prenylation of G Protein γ Subunits
1995
Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.
1990
Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes
2006
Tyrosine Phosphorylation of Rab Proteins
2005
rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif
1991
Isoprenylation of C-terminal cysteine in a G-protein gamma subunit.
1990
Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras.
1990
Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
1985
Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability
1989
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
2006
Isoprenylation of Rab1B is impaired by mutations in its effector domain
1993
Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases
1998
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells
1987
Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.
1991
Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA
1991
Characterization of isoprenoid involved in the post-translational modification of mammalian cell proteins
1989
rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.
1992
Posttranslational modification of proteins by isoprenoids in mammalian cells
1990
Isoprenoid requirement for intracellular transport and processing of murine leukemia virus envelope protein.
1992
Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis
1985
Isoprenoid synthesis during the cell cycle. Studies of 3-hydroxy-3-methylglutaryl-coenzyme A synthase and reductase and isoprenoid labeling in cells synchronized by centrifugal elutriation.
1988