Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
2003 StandoutScience
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
2017 Science
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
2009
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
The many substrates and functions of ATM
2000
The DNA-damage response in human biology and disease
2009 StandoutNature
Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
2000
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
2013
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin α
2004 StandoutNobel
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
2000
Cell cycle checkpoint signaling through the ATM and ATR kinases
2001 Standout
DNA-PKcs and ATM co-regulate DNA double-strand break repair
2009
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Cell-cycle checkpoints and cancer
2004 StandoutNature
Replication Protein A phosphorylation and the cellular response to DNA damage
2004
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM
2006
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku
2011
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein
2010 StandoutNobel
Regulation of DNA double-strand break repair pathway choice
2007
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
2001
RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint
2006
Formation of Arabidopsis Cryptochrome 2 Photobodies in Mammalian Nuclei
2013 StandoutNobel
Nucleotide Excision Repair in Human Cells
2013 StandoutNobel
Deconstructing the photon stream from single nanocrystals: from binning to correlation
2013 StandoutNobel
ATM: Genome stability, neuronal development, and cancer cross paths
2001
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
2005
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures
2004 StandoutNobel
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
2010
Identification and Characterization of Human MUS81-MMS4 Structure-specific Endonuclease
2003 StandoutNobel
Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1
2013
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex
2006 StandoutNobel
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
A dynamic model for replication protein A (RPA) function in DNA processing pathways
2006
Modulation of Replication Protein A Function by Its Hyperphosphorylation-induced Conformational Change Involving DNA Binding Domain B
2005
Chapter 2 DNA-PK
2008
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Purification and Biochemical Characterization of Ataxia‐Telangiectasia Mutated and Mre11/Rad50/Nbs1
2006
ATM and ATR: networking cellular responses to DNA damage
2001
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress
2009
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation
2014
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation
2011
Fluorescence Correlation Spectroscopy: Novel Variations of an Established Technique
2007
Chk2 Activation and Phosphorylation-Dependent Oligomerization
2002
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
DNA structure-specific priming of ATR activation by DNA-PKcs
2013
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress
2006
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
2004
Human DNA Repair Genes
2001 StandoutScienceNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Non-homologous end-joining, a sticky affair
2007
Works of Wesley D. Block being referenced
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
2001
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine
2004
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
2004
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21
2004
Purification and Characterization of ATM from Human Placenta
2000
The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain
2006
Analysis of DNA-Dependent Protein Kinase-Mediated DNA End Joining by Two-Photon Fluorescence Cross-Correlation Spectroscopy
2006