Standout Papers
Citation Impact
Citing Papers
Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining
1989 Nobel
The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses
1994
The T-cell antigen receptor gamma gene: rearrangement and cell lineages
1987 StandoutNobel
Molecular and Cellular Events of T Cell Development
1989
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
1989 StandoutNatureNobel
T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens
1988 Nature
Differential expression and regulation of the human CD8α and CD8β chains
1990
Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes
1989 Nature
Control of γδ T‐Cell Development
1991
Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
1988 Nature
γδ T-cell development
1993 StandoutNobel
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
1992 StandoutNatureNobel
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
1988 Nature
Antibody diversity: Somatic hypermutation of rearranged VH genes
1981
T-cell antigen receptor genes and T-cell recognition
1988 StandoutNature
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
1989 Nature
T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes
1993 Nobel
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
1989
Phage antibodies: filamentous phage displaying antibody variable domains
1990 StandoutNatureNobel
The role of short homology repeats and TdT in generation of the invariant γδ antigen receptor repertoire in the fetal thymus
1995 StandoutNobel
Selection is not required to produce invariant T-cell receptor γ-gene junctional sequences
1993 Nature
Requirement for Positive Selection of γδ Receptor-Bearing T Cells
1991 Science
T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor
1991
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames
1991
The effect of thymus environment on T cell development and tolerance
1988
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
1988 Nature
The adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes
1988 Nature
The Structure, Function, and Molecular Genetics of the gamma/delta T Cell Receptor
1989
Identification of a monoclonal antibody specific for a murine T3 polypeptide.
1987 Standout
Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.
1983 StandoutNobel
T‐T Cell Interactions during Cytotoxic T Lymphocyte (CTL) Responses: T Cell Derived Helper Factor (Interleukin 2) as a Probe to Analyze CTL Responsiveness and Thymic Maturation of CTL Progenitors
1980
Somatic generation of antibody diversity.
1976 StandoutNobel
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes
1982 StandoutNatureNobel
Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines
1982 Nobel
Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.
1992
Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus.
1990 Nobel
Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.
1991 StandoutNobel
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.
1983
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
1984 Nature
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes
1985 Nature
Self-Nonself Discrimination by T Cells
1990 Science
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
1987 StandoutNobel
Direct evidence for binding of CD8 to HLA class I antigens.
1989
Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins
1984 Nature
Genomic organization of the genes encoding mouse T-cell receptor α-chain
1985 Nature
Tγ protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer
1987 StandoutNatureNobel
T-cell gamma gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets.
1987 StandoutNobel
Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes
1987
Mapping of immunoglobulin variable region genes: relationship to the ‘deletion’ model of immunoglobulin gene rearrangement
1981
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.
1989
Developmental regulation of T-cell receptor gene expression
1985 StandoutNatureNobel
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line
1984
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
1981 StandoutNobel
The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse.
1982 StandoutNobel
Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes
1981 Nobel
Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase
1986
Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution
1986 Science
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
1981
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Expression of the T-cell receptor gamma-chain gene products on the surface of peripheral T cells and T-cell blasts generated by allogeneic mixed lymphocyte reaction.
1987 StandoutNobel
T‐Cell Growth Factor
1980
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
1981 StandoutNatureNobel
Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated γ/δ T Cells in Antierythrocyte Immunoglobulin Transgenic Mice
2000 StandoutNobel
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences
1984 StandoutNatureNobel
Early Events in T-Cell Maturation
1987
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes
1984 StandoutNatureNobel
Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene
1985 StandoutScienceNobel
Expression of the T-cell-specific γ gene is unnecessary in T cells recognizing class II MHC determinants
1985 StandoutNatureNobel
The T lymphocyte antigen receptor—paradigm lost
1982 Nature
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.
1982 StandoutNobel
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition
1981
Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.
1982
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.
1991 StandoutNobel
The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor
1984 Nature
Unusual organization and diversity of T-cell receptor a-chain genes
1985 StandoutNatureNobel
The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene
1984
Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells
1984 NatureNobel
Immunoglobulin gene rearrangements in normal mouse B cells.
1982
Ordered rearrangement of immunoglobulin heavy chain variable region segments.
1984 StandoutNobel
Recognition of Self Antigens by Skin-Derived T Cells with Invariant γδ Antigen Receptors
1991 StandoutScienceNobel
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
A second subunit of CD8 is expressed in human T cells.
1988
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
1983 Standout
Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection
1986 StandoutNatureNobel
Chance, necessity and antibody gene dynamics
1983 Nature
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
The T Cell Receptor
1987 Science
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.
1990
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
Characterization of T Cell Receptor Gamma Chain Expression in a Subset of Murine Thymocytes
1986 Science
Diversity, rearrangement, and expression of murine T cell gamma genes
1986
Localization of a T-cell receptor diversity-region element
1984 Nature
Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.
1988
Autonomously proliferating K/D‐restricted cytolytic T cell clones
1983
A Cell Culture Model for T Lymphocyte Clonal Anergy
1990 StandoutScience
Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.
1985
The Role of T Cell Growth Stimulating Factors in T Cell Triggering
1980
Ordered rearrangement of variable region genes of the T cell receptor gamma locus correlates with transcription of the unrearranged genes.
1993
A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus
1987 StandoutNobel
A one-receptor view of T-cell behaviour
1981 Nature
Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.
1989
A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment.
1982 StandoutNobel
The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.
1988
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
1988 StandoutNatureNobel
A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes
1986 StandoutNatureNobel
Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells.
1990 StandoutNobel
The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
1986
Synchronized Rearrangement of T-Cell γ and β Chain Genes in Fetal Thymocyte Development
1986 Science
Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.
1990
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains.
1986 StandoutNobel
A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.
1989
Molecular cloning of cDNA encoding human interleukin-2 receptor
1984 StandoutNatureNobel
Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.
1993 StandoutNobel
The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells
1984
Expression and rearrangement of the alpha, beta, and gamma chain genes of the T cell receptor in cloned murine large granular lymphocyte lines. No correlation with the cytotoxic spectrum.
1986 StandoutNobel
Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire
1993 Science
Works of Werner Haas being referenced
Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia
1990 NatureNobel
Self-tolerance to transgenic γδ T cells by intrathymic inactivation
1990 NatureNobel
Positive selection of γδ T cells
1990 Nobel
Development and selection of γδ T cells
1992 Nobel
Cytotoxic T cell responses to haptenated cells III. Isolation and specificity analysis of continuously growing clones
1980
Functional and phenotypic properties of subpopulations of murine thymocytes.I. The bulk of peanut agglutinin‐positive Lyt‐1,2,3 thymocytes lacks precursors of cytotoxic T lymphocytes responsive to interleukin 2 (T cell growth factor)
1982
Limited diversity of the rearranged T-cell γ gene
1985 StandoutNatureNobel
Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2
1985 Nature
Transfection of the CD8 gene enhances T-cell recognition
1987 Nature
Surface markers of cytotoxic T lymphocyte clones
1984
Fine specificity of a continuously growing killer cell clone specific for H‐Y antigen
1979
Transfer of specificity by murine α and β T-cell receptor genes
1986 Nature
Suppression of T cell responses through competition for T cell growth factor (interleukin 2)
1982
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
1981 StandoutNatureNobel
H‐2 Restricted Cytolytic and Noncytolytic T Cell Clones: Isolation, Specificity and Functional Analysis
1981
Established Murine Cytolytic T‐Cell Lines as Tools for a Somatic Cell Genetic Analysis of T‐Cell Functions
1980