Citation Impact
Citing Papers
Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult
2002 Standout
Monitoring Sedation Status Over Time in ICU Patients
2003 Standout
The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans
2000 Standout
The Role of the α2-Adrenoceptor Agonist Dexmedetomidine in Postsurgical Sedation in the Intensive Care Unit
2003
Effect of Sedation With Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients
2007 Standout
Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients<subtitle>A Randomized Trial</subtitle>
2009 Standout
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice
1998 StandoutNobel
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors
1999 StandoutNobel
Effects of Perioperative Dexmedetomidine Infusion in Patients Undergoing Vascular Surgery
1995
The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
2003 Standout
Gene Substitution/Knockout to Delineate the Role of α2‐Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines
1999 StandoutNobel
Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus
1993
Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery
1996 Standout
Infusion of propofol versus midazolam for sedation in the intensive care unit following coronary artery surgery
1993
Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine
1991
Glutamate uptake
2001 Standout
Cell-type Specific Targeting of the α2c-Adrenoceptor
2000 StandoutNobel
Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
2008 Standout
A meta-analysis of 25 years of mood-creativity research: Hedonic tone, activation, or regulatory focus?
2008 Standout
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
2004 Standout
Ion channels: From idea to reality
1999 StandoutNobel
THE STRESS RESPONSE OF CRITICAL ILLNESS
1999
Molecular and cellular mechanisms of general anaesthesia
1994 StandoutNature
Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide
1988
Pharmacokinetics and Pharmacodynamics of Sedatives and Analgesics in the Treatment of Agitated Critically Ill Patients
1997
Anesthesiology
1997 Standout
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice
2002 StandoutNobel
Physiology of Local Renin-Angiotensin Systems
2006 Standout
Importance of quantitative genetic variations in the etiology of hypertension
2000 StandoutNobel
The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits
1989
Aortic surgery: effect of clonidine on intraoperative catecholaminergic and circulatory stability
1990
Third Universal Definition of Myocardial Infarction
2012 Standout
Medetomidine — a novel α2-adrenoceptor agonist: A review of its pharmacodynamic effects
1989
Hemodynamic stress activates locus coeruleus neurons of unanesthetized rats
1993
Assessment of the role of α2‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
1997
d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α2C-adrenergic receptor subtype
1998 StandoutNobel
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
1990 Standout
Part 8: Advanced life support
2010
Glutamate uptake is not a major target site for anaesthetic agents
1995
Clonidine premedication for coronary artery bypass grafting under high-dose alfentanil anesthesia: Intraoperative and postoperative hemodynamic study
1993
Sympatholytic and Minimum Anesthetic Concentration-sparing Responses are Preserved in Rats Rendered Tolerant to the Hypnotic and Analgesic Action of Dexmedetomidine, a Selective α2-adrenergic Agonist
1996
The Richmond Agitation–Sedation Scale
2002 Standout
Microiontophoretic application of vasoactive agents to the microcirculation of the hamster cheek pouch
1968
A Phase I trial of naloxone treatment in acute spinal cord injury
1985
Ionic channels in nerve membranes
1970
On the Biological Role of Cyclic AMP
1970 StandoutNobel
Upregulation of Immunoreactive Angiotensin II Release and Angiotensinogen mRNA Expression by High-Frequency Preganglionic Stimulation at the Canine Cardiac Sympathetic Ganglia
2001
Evidence That Tetrodotoxin and Saxitoxin Act at a Metal Cation Binding Site in the Sodium Channels of Nerve Membrane
1974 StandoutNobel
Histological Analysis of Coronary Artery Lesions in Fatal Postoperative Myocardial Infarction
1999
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
Beta adrenergic receptors in lymphocyte subpopulations
1980 StandoutNobel
�ber den Einflu� verschiedener kardiotonischer Verbindungen auf die Transport-ATPase in der Zellmembran des Herzmuskels
1962
Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus
1991
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
1989 Standout
Citation Classics in Anesthetic Journals
2004 Standout
α2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding α2-adrenergic receptor subtypes at four distinct levels
1995
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine
2002 StandoutNobel
Metabolism of the heart in health and disease. Part III
1969
Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2BAdrenoceptors
2000 StandoutNobel
Dexmedetomidine as an Anesthetic Adjunct in Coronary Artery Bypass Grafting
1997
STUDIES OF ANAESTHESIA IN RELATION TO HYPERTENSION I: CARDIOVASCULAR RESPONSES OF TREATED AND UNTREATED PATIENTS
1971
Part 8: Post–Cardiac Arrest Care
2015 Standout
Ordering and Administration of Sedatives and Analgesics During the Withholding and Withdrawal of Life Support From Critically III Patients
1992
Bee and Wasp Venoms
1972 StandoutScience
Ion fluxes through the sodium channels of garfish olfactory nerve membranes
1974 StandoutNobel
The beta adrenergic theory of the atopic abnormality in bronchial asthma
1968
Direct Binding Studies of Adrenergic Receptors: Biochemical, Physiologic, and Clinical Implications
1979 StandoutNobel
Solubilization of a specific tetrodotoxin-binding component from garfish olfactory nerve membrane
1972 StandoutNobel
Pharmacologic and Physiologic Aspects of Anesthesiology
1970
Part 14: Pediatric Advanced Life Support
2010 Standout
AN INTEGRATIVE THEORY OF LOCUS COERULEUS-NOREPINEPHRINE FUNCTION: Adaptive Gain and Optimal Performance
2005 Standout
Inhibition of neuronally induced tyrosine hydroxylase by nicotinic receptor blockade
1970 StandoutNobel
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
PROSTACYCLIN (PGI2) INHIBITS THE FORMATION OF PLATELET THROMBI IN ARTERIOLES AND VENULES OF THE HAMSTER CHEEK POUCH
1978 StandoutNobel
Role of the α2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension
1999 StandoutNobel
Opioids and Other Analgesics
1991
Works of Werner Flacke being referenced
STUDIES ON VERATRUM ALKALOIDS. XXVIII. THE ACTION OF THE ERYTHROPHLEUM ALKALOIDS ON THE SINGLE TWITCH AND ON THE "VERATRINE RESPONSE" OF THE SARTORIUS MUSCLE OF THE FROG
1959
NICOTINIC AND MUSCARINIC RECEPTORS IN THE CARDIAC SYMPATHETIC GANGLIA OF THE DOG
1969
Narcotic reversal in hypercapnic dogs: comparison of naloxone and nalbuphine
1990
Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog
1993
Effect of Halothane Concentration on Tachyphylaxis to Sodium Nitroprusside
1989
Effects of calcium on isolated mammalian heart
1964
Reduced Narcotic Requirement by Clonidine with Improved Hemodynamic and Adrenergic Stability in Patients Undergoing Coronary Bypass Surgery
1987
The Peripheral Effects of Anesthetics
1969
Analysis of Halothane in Gas and Blood by Gas Chromatography
1963
The Actions of General Anesthetic Agents on Tracheal Smooth Muscle
1968
Acute Pulmonary Edema Following Naloxone Reversal of High-dose Morphine Anesthesia
1977
THE ACTIONS OF HISTAMINE ON THE MAMMALIAN HEART
1967
IMPULSE TRANSMISSION VIA NICOTINIC AND MUSCARINIC PATHWAYS IN THE STELLATE GANGLION OF THE DOG
1968
Reduction in Halothane Anesthetic Requirement by Clonidine, an Alpha-Adrenergic Agonist
1982
Comparison of Morphine, Meperidine, Fentanyl, and Sufentanil in Balanced Anesthesia; A Double-Blind Study
1986
After-Potentials and Large Depolarizations of Single Nodes of Ranvier Treated with Veratridine
1965
Pharmacology of Reserpine and Its Implications for Anesthesia
1963
A Pharmacological Analysis of Ganglionic Actions of Some General Anesthetics
1968
Actions of Halothane and Norepinephrine in the Isolated Mammalian Heart
1962
Antagonism to Neuromuscular Block by Germine Acetates
1967
Histamine Release by Four Narcotics
1987