Standout Papers
- Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice (2008)
- Neuronal Calcium Sensor Synaptotagmin-9 Is Not Involved in the Regulation of Glucose Homeostasis or Insulin Secretion (2010)
- Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release (2006)
- C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function (2004)
- Synaptotagmins form a hierarchy of exocytotic Ca 2+ sensors with distinct Ca 2+ affinities (2002)
- Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas (2009)
- Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties (2004)
- Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis (2001)
- N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1 (2004)
- Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca 2+ /calmodulin-dependent pathway (2006)
Citation Impact
Citing Papers
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
Visualization of synaptotagmin I oligomers assembled onto lipid monolayers
2003
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Rab3-interacting Molecule γ Isoforms Lacking the Rab3-binding Domain Induce Long Lasting Currents but Block Neurotransmitter Vesicle Anchoring in Voltage-dependent P/Q-type Ca2+ Channels
2010
Direct Interaction of Otoferlin with Syntaxin 1A, SNAP-25, and the L-type Voltage-gated Calcium Channel CaV1.3
2008
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
2007
RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia
2010 StandoutNobel
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion
2006 StandoutNobel
The Presynaptic Dense Projection of theCaenorhabiditis elegansCholinergic Neuromuscular Junction Localizes Synaptic Vesicles at the Active Zone through SYD-2/Liprin and UNC-10/RIM-Dependent Interactions
2011
Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1
2006 StandoutNobel
Ca2+-Dependent Synaptotagmin Binding to SNAP-25 Is Essential for Ca2+-Triggered Exocytosis
2002
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
2009 StandoutNobel
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
Regulated exocytosis and SNARE function (Review)
2003
Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release
2013 StandoutNobel
Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles
2007
Developmental Transformation of the Release Modality at the Calyx of Held Synapse
2005
Synaptotagmin Has an Essential Function in Synaptic Vesicle Positioning for Synchronous Release in Addition to Its Role as a Calcium Sensor
2009 Nobel
Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV
2003
RIM1α and RIM1β Are Synthesized from Distinct Promoters of theRIM1Gene to Mediate Differential But Overlapping Synaptic Functions
2008 StandoutNobel
Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse
2006
Reversal of synaptic vesicle docking at central synapses
1999
Mutation Associated with an Autosomal Dominant Cone-Rod Dystrophy CORD7 Modifies RIM1-Mediated Modulation of Voltage-Dependent Ca2+Channels
2007
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
Synaptotagmin-2 Is Essential for Survival and Contributes to Ca 2+ Triggering of Neurotransmitter Release in Central and Neuromuscular Synapses
2006 StandoutNobel
The Presynaptic Active Zone
2012 StandoutNobel
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Pushing synaptic vesicles over the RIM
2011
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
Neurotransmitter Release at the Thalamocortical Synapse Instructs Barrel Formation But Not Axon Patterning in the Somatosensory Cortex
2012 StandoutNobel
Structure and evolution of RIM-BP genes: Identification of a novel family member
2007
Identification of Candidate Gene Variants in Korean MODY Families by Whole-Exome Sequencing
2015
How Tlg2p/syntaxin 16 'snares' Vps45
2002
Reducing the Environmental Sensitivity of Yellow Fluorescent Protein
2001 StandoutNobel
Membrane Fusion
2003 StandoutNobel
The C2 domains of synaptotagmin – partners in exocytosis
2004
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
2002
Mechanisms of membrane fusion: disparate players and common principles
2008
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
2011
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Synaptotagmin mutants Y311N and K326/327A alter the calcium dependence of neurotransmission
2005
RIM proteins and their role in synapse function
2010
Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons
2007 StandoutNobel
Synaptotagmins: Why So Many?
2002 StandoutNobel
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
2011 StandoutNobel
Synaptotagmin VII modulates the kinetics of dense‐core vesicle exocytosis in PC12 cells
2007
Molecular Cloning, Expression, and Characterization of a Novel Class of Synaptotagmin (Syt XIV) Conserved from Drosophila to Humans
2003
RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13
2011 StandoutNobel
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Roles of the metallothionein family of proteins in the central nervous system
2001
Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis
2011 StandoutNobel
Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling
2003
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
2003
Synaptotagmin VII Is Targeted to Dense-core Vesicles and Regulates Their Ca2+-dependent Exocytosis in PC12 Cells
2004
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
2004 StandoutNobel
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells
2002 StandoutNobel
SNAP‐25 and Synaptotagmin 1 Function in Ca2+‐Dependent Reversible Docking of Granules to the Plasma Membrane
2002
There's more to life than neurotransmission: the regulation of exocytosis by synaptotagmin VII
2005
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Reluctant Vesicles Contribute to the Total Readily Releasable Pool in Glutamatergic Hippocampal Neurons
2005
Localization Versus Function of Rab3 Proteins
2002 StandoutNobel
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Protein S-nitrosylation: purview and parameters
2005 Standout
Presynaptic Capacitance Measurements and Ca2+ Uncaging Reveal Submillisecond Exocytosis Kinetics and Characterize the Ca2+ Sensitivity of Vesicle Pool Depletion at a Fast CNS Synapse
2003
THE SYNAPTIC VESICLE CYCLE
2004 StandoutNobel
Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca2+
2003 StandoutNobel
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
2008 StandoutNobel
Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
2004
Three distinct kinetic groupings of the synaptotagmin family: Candidate sensors for rapid and delayed exocytosis
2005
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
2006 StandoutNobel
Differential but convergent functions of Ca 2+ binding to synaptotagmin-1 C 2 domains mediate neurotransmitter release
2009 StandoutNobel
Miniature Transmitter Release: Accident of Nature or Careful Design?
2003
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII–deficient mice
2003
Push-and-pull regulation of the fusion pore by synaptotagmin-7
2010 StandoutNobel
Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors
2003
Synaptotagmin VII Is Targeted to Secretory Organelles in PC12 Cells, Where It Functions as a High-Affinity Calcium Sensor
2005
Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
2003
Synaptotagmin IX Regulates Ca2+-dependent Secretion in PC12 Cells
2002
Synaptotagmin-1 and -7 are functionally overlapping Ca 2+ sensors for exocytosis in adrenal chromaffin cells
2008 StandoutNobel
Role of synaptotagmin in Ca2+-triggered exocytosis
2002
Regulation of zinc homeostasis by inducible NO synthase-derived NO: Nuclear metallothionein translocation and intranuclear Zn2+release
2003
Unexpected Ca 2+ -binding properties of synaptotagmin 9
2004 StandoutNobel
Structure/Function Analysis of Ca2+Binding to the C2A Domain of Synaptotagmin 1
2002 StandoutNobel
The Synaptotagmins: Calcium Sensors for Vesicular Trafficking
2004
Short-Term Synaptic Plasticity
2002 Standout
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
2002 StandoutNobel
Sr2+ Binding to the Ca2+ Binding Site of the Synaptotagmin 1 C2B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions
2003 StandoutNobel
Emerging Roles of Presynaptic Proteins in Ca ++ -Triggered Exocytosis
2002 ScienceNobel
Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human
2002
cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala
2008
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
RIM genes differentially contribute to organizing presynaptic release sites
2012 StandoutNobel
Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein
2002
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells
2003
Synaptotagmin VII splice variants α, β, and δ are expressed in pancreatic β‐cells and regulate insulin exocytosis
2007
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Synaptotagmin Isoforms Couple Distinct Ranges of Ca2+, Ba2+, and Sr2+Concentration to SNARE-mediated Membrane Fusion
2005
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles
2004
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells
2004
Different Effects on Fast Exocytosis Induced by Synaptotagmin 1 and 2 Isoforms and Abundance But Not by Phosphorylation
2006 StandoutNobel
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
2008 StandoutNobel
Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells
2007
Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release
2007
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Works of Weiping Han being referenced
Synaptotagmins form a hierarchy of exocytotic Ca 2+ sensors with distinct Ca 2+ affinities
2002 StandoutNobel
C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function
2004 StandoutNobel
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
2004 StandoutNobel
Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties
2004 StandoutNobel
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas
2009 StandoutNobel
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis
2001 StandoutNobel
Neuronal Peptide Release Is Limited by Secretory Granule Mobility
1997
Neuronal Calcium Sensor Synaptotagmin-9 Is Not Involved in the Regulation of Glucose Homeostasis or Insulin Secretion
2010 StandoutNobel
Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion
2009
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein
2000
Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca 2+ /calmodulin-dependent pathway
2006 StandoutNobel
Ca2+-Induced Deprotonation of Peptide Hormones Inside Secretory Vesicles in Preparation for Release
1999