Standout Papers
- Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer (2013)
- A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication (2013)
- PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia (2016)
- Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells (2011)
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 (2011)
- Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration (2018)
- Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis (2012)
- Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression (2013)
- Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart (2013)
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 (2011)
- Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression (2012)
- Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α (2009)
- Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia (2011)
- Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis (2013)
- HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells (2015)
- PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility (2014)
- Hypoxia-inducible factors enhance glutamate signaling in cancer cells (2014)
- Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014)
- Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis (2014)
- MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1 (2011)
- Emerging roles of PKM2 in cell metabolism and cancer progression (2012)
- Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype (2014)
- Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue (2011)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
2019
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
2012
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
2017
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Regulation of hypoxia‐inducible factor‐α isoforms and redox state by carotid body neural activity in rats
2014 StandoutNobel
The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
2011
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
2019 StandoutNobel
Passing the baton: the HIF switch
2012
TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
2014
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea
2015 StandoutNobel
Cancer Cell Metabolism
2011
Transcription factor Foxp3 and its protein partners form a complex regulatory network
2012
MYC on the Path to Cancer
2012 Standout
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
2014
Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
2011
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Pre-metastatic niches: organ-specific homes for metastases
2017
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia
2016
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment
2017 StandoutNobel
Post-translational modifications and the Warburg effect
2013
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
2012 StandoutNobel
Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult
2015
Regulation of immunity and inflammation by hypoxia in immunological niches
2017
Systemic VHL gene functions and the VHL disease
2012
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
2014 StandoutNobel
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Xanthine Oxidase Mediates Hypoxia-Inducible Factor-2α Degradation by Intermittent Hypoxia
2013
Shedding light on the cell biology of extracellular vesicles
2018 Standout
The hypoxic tumor microenvironment: A driving force for breast cancer progression
2015 StandoutNobel
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Targeting proteinase-activated receptors: therapeutic potential and challenges
2012
Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles
2013 StandoutNobel
Hypoxia: Signaling the Metastatic Cascade
2016
The dichotomous nature of T helper 17 cells
2017
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
2011 Nature
HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase
2015 StandoutNobel
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
2014
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
2015
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body
2012
Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment
2013
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
2012
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Development and Maintenance of Regulatory T cells
2013 StandoutNobel
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer
2012
Peripheral Chemoreception and Arterial Pressure Responses to Intermittent Hypoxia
2015
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
2012 StandoutNobel
Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
2014
Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
2012
Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus
2013 StandoutNobel
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes
2015
Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases
2013
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
2016 StandoutNobel
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells
2016 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Hypoxia-Inducible Factor 1 and Cardiovascular Disease
2013 StandoutNobel
Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis
2012
Role of Hypoxia-Inducible Factors in Breast Cancer Metastasis
2013 StandoutNobel
Sympatho-adrenal activation by chronic intermittent hypoxia
2012
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Going live with tumor exosomes and microvesicles
2017
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
2013 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Biology and biogenesis of shed microvesicles
2016
The role of hypoxia‐inducible factors in carotid body (patho) physiology
2018 StandoutNobel
Induced CD4+Foxp3+Regulatory T Cells in Immune Tolerance
2012
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
2014 Standout
Regulation of cell proliferation by hypoxia-inducible factors
2015 StandoutNobel
A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
2016
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Targeting Protein–Protein Interactions in the HIF System
2016
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia
2015
H 2 S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea
2016 StandoutNobel
Works of Weibo Luo being referenced
Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
2014 StandoutNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1
2011 StandoutNobel
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression
2013 StandoutNobel
Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells
2016
Protease‐activated receptor‐1 protects rat astrocytes from apoptotic cell death via JNK‐mediated release of the chemokine GRO/CINC‐1
2006
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
2012 StandoutNobel
Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia
2011 StandoutNobel
Protease-activated receptors in the brain: Receptor expression, activation, and functions in neurodegeneration and neuroprotection
2007
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer
2013 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
2014 StandoutNobel
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
2013 StandoutNobel
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue
2011 StandoutNobel
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
2013 StandoutNobel
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells
2015 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel