Standout Papers
Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Argonaute2 Is the Catalytic Engine of Mammalian RNAi
2004 StandoutScience
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Structure of a Synaptic γδ Resolvase Tetramer Covalently Linked to Two Cleaved DNAs
2005 StandoutScienceNobel
Origins of Specificity in Protein-DNA Recognition
2010
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
2003
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
2004
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
2004 Science
The Interaction of DNA Mismatch Repair Proteins with Human Exonuclease I
2001
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA
1995 StandoutNatureNobel
ATP Increases the Affinity between MutS ATPase Domains
2004
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Mutations within the hMLH1 and hPMS2 Subunits of the Human MutLα Mismatch Repair Factor Affect Its ATPase Activity, but Not Its Ability to Interact with hMutSα
2002
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements
2009
Mismatch Recognition and DNA-dependent Stimulation of the ATPase Activity of hMutSα Is Abolished by a Single Mutation in the hMSH6 Subunit
2000
Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
2012 StandoutNobel
The Architecture of the γδ Resolvase Crossover Site Synaptic Complex Revealed by Using Constrained DNA Substrates
2003
Mismatch Repair in Human Nuclear Extracts
2003
Signals and Combinatorial Functions of Histone Modifications
2011
Tuning in to Interference: R-Loops and Cascade Complexes in CRISPR Immunity
2012
H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations
2009
Distinct MutS DNA-binding Modes That Are Differentially Modulated by ATP Binding and Hydrolysis
2001 StandoutNobel
Transfer of the MSH2·MSH6 Complex from Proliferating Cell Nuclear Antigen to Mispaired Bases in DNA
2002
A Model for the γδ Resolvase Synaptic Complex
2001
Escherichia coli MutL Loads DNA Helicase II onto DNA
2000
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair
2004
The β Sliding Clamp Binds to Multiple Sites within MutL and MutS
2006 StandoutNobel
Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense
2009 StandoutNobel
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Error-Prone DNA Polymerases
2001
Structural and Biochemical Analysis of Nuclease Domain of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Protein 3 (Cas3)
2011
Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III
2006
The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific endoribonuclease
2015
Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
2020
Differential and Simultaneous Adenosine Di- and Triphosphate Binding by MutS
2003 StandoutNobel
Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity
2012
Hydrolytically Deficient MutS E694A Is Defective in the MutL-dependent Activation of MutH and in the Mismatch-dependent Assembly of the MutS · MutL · Heteroduplex Complex
2003 StandoutNobel
ATP hydrolysis-dependent formation of a dynamic ternary nucleoprotein complex with MutS and MutL
1999
Did DNA replication evolve twice independently?
1999
Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a
2017
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
2008
Structure of the guide-strand-containing argonaute silencing complex
2008 Nature
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase
2001
DNA mismatch repair: MutS structures bound to mismatches
2001
A Sliding-Clamp Toolbelt Binds High- and Low-Fidelity DNA Polymerases Simultaneously
2005
Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates
2003
Functional Inferences from Blind ab Initio Protein Structure Predictions
2001 StandoutNobel
Activating mutations of Tn3 resolvase marking interfaces important in recombination catalysis and its regulation
2003
Structural Biology of Rad50 ATPase
2000
Molecular mechanisms of DNA mismatch repair
2001
Challenges and opportunities for structural DNA nanotechnology
2011
Assembly and Molecular Activities of the MutS Tetramer
2003 StandoutNobel
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate
2018 Nature
Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites
2008
Structures of Mismatch Replication Errors Observed in a DNA Polymerase
2004
DNA mismatch repair and mutation avoidance pathways
2002
Activation of Human MutS Homologs by 8-Oxo-guanine DNA Damage
2002
Mismatch repair proteins: key regulators of genetic recombination
2004
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Dominant Saccharomyces cerevisiae msh6 Mutations Cause Increased Mispair Binding and Decreased Dissociation from Mispairs by Msh2-Msh6 in the Presence of ATP
2002
Contribution of Human Mlh1 and Pms2 ATPase Activities to DNA Mismatch Repair
2002
The multifaceted mismatch-repair system
2006
On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family
2009
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases
2006 StandoutNobel
Mismatch Repair in Human Nuclear Extracts
2002
The evolutionary journey of Argonaute proteins
2014
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
2008 Nature
Atomic structure of the RuvC resolvase: A holliday junction-specific endonuclease from E. coli
1994
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
2004
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass
2002
The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation
2012 StandoutNobel
Formation of a DNA Mismatch Repair Complex Mediated by ATP
2003
On/off blinking and switching behaviour of single molecules of green fluorescent protein
1997 StandoutNatureNobel
Signaling from DNA mispairs to mismatch‐repair excision sites despite intervening blockades
2004
MutS Preferentially Recognizes Cisplatin- over Oxaliplatin-modified DNA
2002
Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme
2009 Nature
Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes
2000
Structural basis for transcription inhibition by tagetitoxin
2005
Trading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?
2005
A role for MLH3 in hereditary nonpolyposis colorectal cancer
2001
The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion
1996
The Coordinated Functions of the E. coli MutS and MutL Proteins in Mismatch Repair
2003
Purified Argonaute2 and an siRNA form recombinant human RISC
2005
Interaction of Escherichia coli MutS and MutL at a DNA Mismatch
2001
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Evidence for sequential action of two ATPase active sites in yeast Msh2–Msh6
2002
Structure of yeast Argonaute with guide RNA
2012 Nature
Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity
1999
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
RNA helicases — one fold for many functions
2007
In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination
2003
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
DNA Replication Fidelity
2004
Tn3 resolvase catalyses multiple recombination events without intermediate rejoining of DNA ends 1 1 Edited by J. Karn
1997
DNA Mismatch Repair
2000
Genetic predisposition to colorectal cancer
2004
MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp
2001
Crystal structure of RuvC resolvase in complex with Holliday junction substrate
2013
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
2005 Nature
Differential Specificities and Simultaneous Occupancy of Human MutSα Nucleotide Binding Sites
2004 StandoutNobel
Mapping Protein-Protein Interactions between MutL and MutH by Cross-linking
2004
HIV reverse transcriptase structure-function relationships
1991
A Plant Homeodomain in Rag-2 that Binds Hypermethylated Lysine 4 of Histone H3 Is Necessary for Efficient Antigen-Receptor-Gene Rearrangement
2007
Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant
2005
SSO1450 – A CAS1 protein from Sulfolobus solfataricus P2 with high affinity for RNA and DNA
2009
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
2010
Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps
2000
Structural Insights into the Origins of DNA Polymerase Fidelity
2003
Fitting CRISPR-associated Cas3 into the Helicase Family Tree
2014
Mismatch Repair in Human Nuclear Extracts
2002
High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer 1 1Edited by M. Belfort
2001
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
2010
Solution Structure of the Tn3 Resolvase-Crossover Site Synaptic Complex
2004
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Crystal Structure of A. aeolicus Argonaute, a Site-Specific DNA-Guided Endoribonuclease, Provides Insights into RISC-Mediated mRNA Cleavage
2005
The MutL ATPase Is Required for Mismatch Repair
2000 StandoutNobel
Influence of Combinatorial Histone Modifications on Antibody and Effector Protein Recognition
2010
Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1
1999
The crystal structure of DNA mismatch repair protein MutS binding to a G·T mismatch
2000 Nature
An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity
2020 Nature
Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation
2014
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
Mammalian DNA mismatch repair protects cells from UVB-induced DNA damage by facilitating apoptosis and p53 activation
2003
Architecture of the γδ Resolvase Synaptosome
1998
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
2011
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Analysis of Interactions Between Mismatch Repair Initiation Factors and the Replication Processivity Factor PCNA
2005
DNA Chain Length Dependence of Formation and Dynamics of hMutSα·hMutLα·Heteroduplex Complexes
2001 StandoutNobel
Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems
2018
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the -clamp
2003
Architecture of the Hin Synaptic Complex during Recombination
2004
The alternating ATPase domains of MutS control DNA mismatch repair
2003
The molecular structure of green fluorescent protein
1996
Mammalian DNA Mismatch Repair
1999
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
The role of hMLH3 in familial colorectal cancer.
2003
Mutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies
2000
Spatially-Interactive Biomolecular Networks Organized by Nucleic Acid Nanostructures
2012
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
DNA MISMATCH REPAIR
2005
Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor
1992 StandoutScience
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
2002
DNA bending and unbending by MutS govern mismatch recognition and specificity
2003
Quality Control by DNA Repair
1999 StandoutScienceNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair
2012
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Heteroduplex DNA and ATP induced conformational changes of a MutS mismatch repair protein from Thermus aquaticus
2000
Eukaryotic DNA mismatch repair
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage
2013
The ribonuclease activity of Csm6 is required for anti-plasmid immunity by Type III-A CRISPR-Cas systems
2018
DNA Mismatch Repair: Molecular Mechanisms and Biological Function
2003
Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase
1991
Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase
1991 Science
Accuracy, lesion bypass, strand displacement and translocation by DNA polymerases
2004 StandoutNobel
DNA origami protection and molecular interfacing through engineered sequence-defined peptoids
2020 StandoutNobel
exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair
2001
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.
1994
Functional Studies on the Candidate ATPase Domains of Saccharomyces cerevisiae MutLα
2000
CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
2013
Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
1999
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I
2001
Mismatch Recognition-Coupled Stabilization of Msh2-Msh6 in an ATP-Bound State at the Initiation of DNA Repair
2003
Crystal Structure of the Catalytic Domain of HIV-1 Integrase: Similarity to Other Polynucleotidyl Transferases
1994 Science
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
Structure of Escherichia coli ribosomal protein L25 complexed with a 5S rRNA fragment at 1.8-Å resolution
2000 StandoutNobel
Implications of structures of synaptic tetramers of γδ resolvase for the mechanism of recombination
2006 StandoutNobel
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
The MutS C Terminus Is Essential for Mismatch Repair Activity In Vivo
2005
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Asymmetric ATP Binding and Hydrolysis Activity of the Thermus aquaticus MutS Dimer Is Key to Modulation of Its Interactions with Mismatched DNA
2004
STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY
2005 StandoutNobel
Works of Wei Yang being referenced
The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2
2007
Crystal structure of the site-specific recombinase γδ resolvase complexed with a 34 by cleavage site
1995 StandoutNobel
Composite Active Site of an ABC ATPase
2001
UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke
2006
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity
2006
Disruption of the helix-u-turn-helix motif of MutS protein: loss of subunit dimerization, mismatch binding and ATP hydrolysis
2001
Crystal Structure of a Y-Family DNA Polymerase in Action
2001
Poor base stacking at DNA lesions may initiate recognition by many repair proteins
2006
Replication of a cis–syn thymine dimer at atomic resolution
2003 Nature
Crystal Structure and Biochemical Analysis of the MutS·ADP·Beryllium Fluoride Complex Suggests a Conserved Mechanism for ATP Interactions in Mismatch Repair
2003
An equivalent metal ion in one- and two-metal-ion catalysis
2008
Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis
2005
Transformation of MutL by ATP Binding and Hydrolysis
1999
Damage repair DNA polymerases Y
2003
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
2006
Structural and functional modules in RNA interference
2009
Structure and function of mismatch repair proteins
2000
Recombining the structures of HIV integrase, RuvC and RNase H
1995 StandoutNobel
DNA Mismatch Repair: From Structure to Mechanism
2000
Structure of the MutL C‐terminal domain: a model of intact MutL and its roles in mismatch repair
2004
Oligomerization of a MutS Mismatch Repair Protein from Thermus aquaticus
1999
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA
2000 Nature
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
1999
Crystal structure of T4 endonuclease VII resolving a Holliday junction
2007 Nature
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
2004
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
2007 Nature
Nucleases: diversity of structure, function and mechanism
2010
Crystal Structure and ATPase Activity of MutL
1998
Asymmetric Recognition of DNA Local Distortion
2001
Protein–nucleic acid interactions
2004
Expression, purification, and crystallization of natural and selenomethionyl recombinant ribonuclease H from Escherichia coli.
1990
Lessons Learned from UvrD Helicase: Mechanism for Directional Movement
2010
DNA Scissors Device Used to Measure MutS Binding to DNA Mis-pairs
2010
Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage
2014
Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein
1990 Science