Standout Papers
- PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase (2009)
- OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation (2014)
- Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor (2010)
- Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases (2016)
- Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy (2014)
- Factor‐inhibiting hypoxia‐inducible factor (FIH) catalyses the post‐translational hydroxylation of histidinyl residues within ankyrin repeat domains (2011)
- Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth (2014)
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
RNA interference microarrays: High-throughput loss-of-function genetics in mammalian cells
2004
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
2015
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
2015 StandoutNobel
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
2005 StandoutNobel
RNAi and HTS: exploring cancer by systematic loss-of-function
2004
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
2010
Large-scale de novo DNA synthesis: technologies and applications
2014
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
2012
Accurate design of co-assembling multi-component protein nanomaterials
2014 StandoutNatureNobel
Beyond natural antibodies: the power of in vitro display technologies
2011
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
2008
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing
2009
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
2012 StandoutNobel
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
2005
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins
2017
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
2015
RNA interference against viruses: strike and counterstrike
2007
Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo
2014
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
2009
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis
2009
Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity
2013
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
2006
A loss-of-function RNA interference screen for molecular targets in cancer
2006 Nature
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Oxygen-dependent hydroxylation by Factor Inhibiting HIF (FIH) regulates the TRPV3 ion channel
2014
Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
2011 StandoutNobel
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
2020 StandoutNobel
Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors
2005
Pooled shRNA Screenings: Experimental Approach
2012
A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells
2010
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
2008 Standout
Genome-wide in situ exon capture for selective resequencing
2007
Challenges for structure-based HIV vaccine design
2009
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc
2007
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
2006
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi
2006
Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
2010 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
2005
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Prevalence of off-target effects in Drosophila RNA interference screens
2006 Nature
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
2006
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
2015
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
2012
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection
2015
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells
2005
Delivery of siRNA and siRNA Expression Constructs to Adult Mammals by Hydrodynamic Intravascular Injection
2005
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
2008 StandoutNobel
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
2011 StandoutNobel
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
Clonal B cells in patients with hepatitis C virus–associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset
2011 StandoutNobel
Chromatin and oxygen sensing in the context of JmjC histone demethylases
2014
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses
2012 Science
Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages
2014
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
Kinase requirements in human cells: I. Comparing kinase requirements across various cell types
2008
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Structural insights into key sites of vulnerability on HIV ‐1 Env and influenza HA
2012
Targeting Protein–Protein Interactions in the HIF System
2016
Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1
2012
Photothermal Nanomaterials: A Powerful Light-to-Heat Converter
2023 Standout
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
2010 StandoutScienceNobel
Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes
2009 StandoutScienceNobel
Works of Wei Ge being referenced
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
2004
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
2009
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase
2009 StandoutNobel
The Role of Lipid Bodies in the Microglial Aging Process and Related Diseases
2017
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis
2004
Second-generation shRNA libraries covering the mouse and human genomes
2005
Substrate Selectivity Analyses of Factor Inhibiting Hypoxia‐Inducible Factor
2013
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
2014 Nature
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
2010
Linking of 2‐Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
2012
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
Factor‐inhibiting hypoxia‐inducible factor (FIH) catalyses the post‐translational hydroxylation of histidinyl residues within ankyrin repeat domains
2011 StandoutNobel
Crystal structure of the PHF8 Jumonji domain, an Nε‐methyl lysine demethylase
2010
Mesoporous Silica Supported Silver–Bismuth Nanoparticles as Photothermal Agents for Skin Infection Synergistic Antibacterial Therapy
2020
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
2014
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel