Standout Papers
Citation Impact
Citing Papers
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
2005
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Phenotypic and functional features of human Th17 cells
2007 Standout
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
2006
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
2006
Self-organization of a propulsive actin network as an evolutionary process
2001
IL-25 regulates Th17 function in autoimmune inflammation
2007
Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions
2001 Science
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
2008
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
2003 Standout
Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis
2006
T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity
2007
IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis
2007
Essential Roles of c-Rel in TLR-Induced IL-23 p19 Gene Expression in Dendritic Cells
2007
B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones
2008
IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis
2007
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
2019 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells
2015
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
2006 Standout
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
2000 Nature
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
2000
Atopic Dermatitis
2008 Standout
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
2006
Interferons as pathogenic effectors in autoimmunity
2005
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
2014
The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins
2000
Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
2006
Interleukin-17 Family Members and Inflammation
2004 Standout
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
2003
Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation
2006
IL-23 mediates inflammatory responses to mucoidPseudomonas aeruginosalung infection in mice
2006
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
2006
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Induction and molecular signature of pathogenic TH17 cells
2012
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
2007
Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein
2000 Nature
TH17 cells in development: an updated view of their molecular identity and genetic programming
2008
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
2008
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
2005 Standout
The IL-12 Family of Heterodimeric Cytokines
2003
IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity in vivo
2008
Cdc42-induced actin filaments are protected from capping protein
1999
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
2006
Activation of the Arp2/3 Complex by the Listeria ActA Protein
2001
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice
2007
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
2011
Autoimmune T cell responses in the central nervous system
2009
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
2007 Standout
Development, cytokine profile and function of human interleukin 17–producing helper T cells
2007 Standout
IL-12– and IL-23–induced T helper cell subsets
2005
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
2011
Nanocarriers as an emerging platform for cancer therapy
2007 Standout
Structure and function of the Arp2/3 complex
1999
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
2008
Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
2008
GRB2 Links Signaling to Actin Assembly by Enhancing Interaction of Neural Wiskott-Aldrich Syndrome Protein (N-WASp) with Actin-related Protein (ARP2/3) Complex
2000
Induction and effector functions of TH17 cells
2008 Nature
Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells
2006
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
2007
Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology
2006
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
1999 Nature
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
2007
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
2005
Interleukin-17 and Type 17 Helper T Cells
2009 Standout
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
2005
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
2015
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
2006
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
2009
Control of actin assembly and disassembly at filament ends
2000
Expanding the effector CD4 T-cell repertoire: the Th17 lineage
2006
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
2014
How microorganisms tip the balance between interleukin-12 family members
2007
IL-23 promotes tumour incidence and growth
2006 Nature
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
2011
The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
2008
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Immune surveillance in the skin: mechanisms and clinical consequences
2004
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
2006
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
2006
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
2007 Standout
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
2005 Standout
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
2007
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
2008 Standout
A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes
2007
Both IL-12p70 and IL-23 are synthesized during active Crohnʼs disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
2005
Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities
2001
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Multiple Sclerosis — The Plaque and Its Pathogenesis
2006
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes
2004
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
Interaction of Cortactin and N-WASp with Arp2/3 Complex
2002
Th17: the third member of the effector T cell trilogy
2007
IL‐12 and IL‐23: master regulators of innate and adaptive immunity
2004
Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis
2003
A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
2007
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
2005
The IL-23/IL-17 axis in inflammation
2006
Activation of Arp2/3 complex-mediated actin polymerization by cortactin
2001
Cancer-related inflammation
2008 StandoutNature
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
2002 Standout
Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display
2008
TH-17 cells in the circle of immunity and autoimmunity
2007
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
2008
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
Understanding the IL-23–IL-17 immune pathway
2005
Polarized immune responses differentially regulate cancer development
2008
T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation
2007
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
2003 Standout
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
2006
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex
2000
Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis
2003
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
2005 Standout
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
2014
Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes
2008
Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins
2001
Crystal Structure of Arp2/3 Complex
2001 Science
Three Regions within Acta Promote Arp2/3 Complex-Mediated Actin Nucleation and Listeria monocytogenes Motility
2000
Strategies for extended serum half-life of protein therapeutics
2011
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
2000
IL-17 and Th17 Cells
2009 Standout
IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12
2004
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
2007 Standout
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
2006
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
IMMUNOLOGY OF MULTIPLE SCLEROSIS
2005 Standout
Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris
2004
Profilin Enhances Cdc42-Induced Nucleation of Actin Polymerization
2000
Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice
2004
Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway
2004
IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease
2007
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
2005 StandoutNobel
Prostaglandin E2 induces IL‐23 production in bone marrow‐derived dendritic cells
2004
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
2008
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Conditional stability of T cells
2010 StandoutNatureNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Stop That Cell! β-Arrestin-Dependent Chemotaxis: A Tale of Localized Actin Assembly and Receptor Desensitization
2006
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype
2007
Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks
2000
Direct Involvement of Yeast Type I Myosins in Cdc42-Dependent Actin Polymerization
2000
Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of β cells
2007 StandoutNobel
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
2007
Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate
2000
Activation of the Arp2/3 Complex by the Actin Filament Binding Protein Abp1p
2001
Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases
2015
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments
2001
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
2006
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Cutting Edge: Diabetes-Associated Quantitative Trait Locus, Idd4, Is Responsible for the IL-12p40 Overexpression Defect in Nonobese Diabetic (NOD) Mice
2003
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
2006
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
2007 StandoutNobel
Works of Wayne To being referenced
The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
1999
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
2002
Gcg-XTEN: An Improved Glucagon Capable of Preventing Hypoglycemia without Increasing Baseline Blood Glucose
2010
Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
2005
A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
2009