Citation Impact
Citing Papers
TFEB Links Autophagy to Lysosomal Biogenesis
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Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion
2007
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase
2007 Science
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
2008 StandoutScience
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
2003
The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
2007
TOR Signaling in Growth and Metabolism
2006 Standout
Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
2014
Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation
2016
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase
2011
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
2014
AMP-activated protein kinase: also regulated by ADP?
2011
The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae
1999
Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4
2000
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
2010
SNF1/AMPK pathways in yeast
2007
SNF1/AMPK/SnRK1 kinases, global regulators at the heart of energy control?
2006
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
Regulation of AMP‐activated protein kinase by a pseudosubstrate sequence on the γ subunit
2007
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
2010
hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase
2005
Snf1‐related protein kinase 1 is needed for growth in a normal day–night light cycle
2004
Oncogenic kinase signalling
2001 StandoutNature
AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint
2005
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
2011 Standout
Regulation and role of autophagy in mammalian cells
2004
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction
2015
AMP-activated Protein Kinase β Subunit Tethers α and γ Subunits via Its C-terminal Sequence (186–270)
2005
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase
2006
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
2010
5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms
1995
Ald6p Is a Preferred Target for Autophagy in Yeast, Saccharomyces cerevisiae
2004 StandoutNobel
Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell Death
2007
SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy
2008
The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
1996
The Nuclear Ubiquitin-Proteasome System Degrades MyoD
2001 StandoutNobel
Rare and unusual glycosylation of peptides and proteins
2012
Autophagy: Renovation of Cells and Tissues
2011 Standout
ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury
2001 StandoutNobel
The AMP‐Activated Protein Kinase
1997
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Rewiring AMPK and Mitochondrial Retrograde Signaling for Metabolic Control of Aging and Histone Acetylation in Respiratory-Defective Cells
2014
Network organization of the human autophagy system
2010 StandoutNature
Autophagy in the Pathogenesis of Disease
2008 Standout
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
2015
Autophagy in metazoans: cell survival in the land of plenty
2005
Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site
2003
Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases
2005
Structural Insight into AMPK Regulation: ADP Comes into Play
2007
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
2017 Nature
Signalling and autophagy regulation in health, aging and disease
2006
AMPK functions as an adenylate charge-regulated protein kinase
2012
Transcriptional regulatory code of a eukaryotic genome
2004 StandoutNature
Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex
2003
Reserve carbohydrates metabolism in the yeastSaccharomyces cerevisiae
2001
The Autophagy-related Protein Kinase Atg1 Interacts with the Ubiquitin-like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation
2012 StandoutNobel
Conserved α-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase α Subunits
2006
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
2004
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
1998
AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis
2006
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate
2002
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
2007 Standout
Autophagy Is Required for Maintenance of Amino Acid Levels and Protein Synthesis under Nitrogen Starvation
2005 StandoutNobel
Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2
2007
The Hallmarks of Aging
2013 Standout
Subunit and Domain Requirements for Adenylate-mediated Protection of Snf1 Kinase Activation Loop from Dephosphorylation*
2011
Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP
1999
The Ded1/DDX3 subfamily of DEAD-box RNA helicases
2014
Active genes are tri-methylated at K4 of histone H3
2002 StandoutNature
Autophagy regulation by nutrient signaling
2013
Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate
2015
Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
2013
Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy
2012 StandoutNobel
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
2004
Fuel feeds function: energy metabolism and the T-cell response
2005
The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
2007
Autophagy in immunity and inflammation
2011 StandoutNature
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
1999 Standout
Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations inSaccharomyces cerevisiae
1999
Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site
2012 StandoutNobel
Function of Mammalian LKB1 and Ca2+/Calmodulin-dependent Protein Kinase Kinase α as Snf1-activating Kinases in Yeast
2005
The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8‐Tup1 co‐repressor
2004
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
2007
Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
2008
Protein–protein interactions define specificity in signal transduction
2000
THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
1998
Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms
2004
Glucose Depletion Rapidly Inhibits Translation Initiation in Yeast
2000
Autophosphorylation Within the Atg1 Activation Loop Is Required for Both Kinase Activity and the Induction of Autophagy in Saccharomyces cerevisiae
2010
Genome-Wide Location and Function of DNA Binding Proteins
2000 Science
AMP-Activated Protein Kinase in the Heart
2007
Driving the Cell Cycle Through Metabolism
2011
Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase
1996
AMP-Activated Protein Kinase as a Drug Target
2006
Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae
2015 StandoutNobel
Yeast Pak1 Kinase Associates with and Activates Snf1
2003
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
The Snf1 Protein Kinase and Its Activating Subunit, Snf4, Interact with Distinct Domains of the Sip1/Sip2/Gal83 Component in the Kinase Complex
1997
Regulation Mechanisms and Signaling Pathways of Autophagy
2009 Standout
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
2011
Combining chemical genetics and proteomics to identify protein kinase substrates
2005
A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion
2002
Spermidine in health and disease
2018 StandoutScience
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
2008
A Genomic Screen for Yeast Mutants Defective in Selective Mitochondria Autophagy
2009
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
2000 Standout
Phototropin Blue-Light Receptors
2006
HowSaccharomycesResponds to Nutrients
2008
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
1998
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Ultrafast Dynamics of Flavins in Five Redox States
2008 StandoutNobel
The regulation of autophagy – unanswered questions
2010
Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
2000
Autophagy and Metabolism
2010 StandoutScience
Degradation of the Transcription Factor Gcn4 Requires the Kinase Pho85 and the SCFCDC4Ubiquitin–Ligase Complex
2000
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
2015
AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes
1999
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase
2012
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release
1998
Transcriptomic and Proteomic Analysis of a 14-3-3 Gene-Deficient Yeast
2004 StandoutNobel
Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase
2000
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP
2009
Metabolic-Stress-Induced Rearrangement of the 14-3-3ζ Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3ζ Interaction with Phosphorylated Atg9
2014
Ultrafast Dynamics and Anionic Active States of the Flavin Cofactor in Cryptochrome and Photolyase
2008 StandoutNobel
Global Analysis of Protein Activities Using Proteome Chips
2001 StandoutScience
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae
1998
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
2007 StandoutScienceNobel
Chemical Glycoproteomics
2016 StandoutNobel
Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response
2001
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
2001
Ca2+/CaM-Dependent Kinases: From Activation to Function
2001
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Wayne A. Wilson being referenced
Glucose-6-P Control of Glycogen Synthase Phosphorylation in Yeast
1997
Biochemical characterization of Neurospora crassa glycogenin (GNN), the self‐glucosylating initiator of glycogen synthesis
2005
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1
1999
Systematic Identification of the Genes Affecting Glycogen Storage in the Yeast Saccharomyces cerevisiae
2002
Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio
1996
Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I
1995
Nutrient-Regulated Protein Kinases in Budding Yeast
2002
Cyclin Partners Determine Pho85 Protein Kinase Substrate Specificity In Vitro and In Vivo: Control of Glycogen Biosynthesis by Pcl8 and Pcl10
1998
Substrate Targeting of the Yeast Cyclin-Dependent Kinase Pho85p by the Cyclin Pcl10p
1999
Regulation of Glycogen Synthase
2000
Control of mammalian glycogen synthase by PAS kinase
2005
Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p
2001