Citation Impact
Citing Papers
NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
2008
PIK3R1 (p85α) Is Somatically Mutated at High Frequency in Primary Endometrial Cancer
2011
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
PIK3CA Cooperates with Other Phosphatidylinositol 3′-Kinase Pathway Mutations to Effect Oncogenic Transformation
2008
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
2005
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
2007 Science
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
2005
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
PTEN-deficient cancers depend on PIK3CB
2008
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma
2005
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
2019
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Response and determinants of cancer cell susceptibility to PI3K inhibitors: Combined targeting of PI3K and Mek1 as an effective anticancer strategy
2008
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Caught up in a Wnt storm: Wnt signaling in cancer
2003
Genetic Alterations of Phosphoinositide 3‐kinase Subunit Genes in Human Glioblastomas
2004
Analysis of the genome to personalize therapy for melanoma
2010
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells
2000
Derailed endocytosis: an emerging feature of cancer
2008
Class I PI3K in oncogenic cellular transformation
2008
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
2005
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Neutrophil priming mechanisms of sulfolipid-I and n-formyl-methionyl-leucyl-phenylalanine
1994
Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α
2008
Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma
2009
Wnt signaling in the intestinal epithelium: from endoderm to cancer
2005
Oncogenic PI3K and its role in cancer
2005
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.
2001
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Pancreatic Adenocarcinoma
2014 Standout
Colorectal cancer
2019 Standout
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
2007
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
1993 StandoutNatureNobel
Protein‐Reactive Natural Products
2005
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1994 StandoutNature
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
Plant pathogens and integrated defence responses to infection
2001 StandoutNature
Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer
2013 Standout
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit
2005
Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
2008
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The prevalence of PIK3CA mutations in gastric and colon cancer
2005
The Hallmarks of Aging
2013 Standout
Wnt signalling in stem cells and cancer
2005 StandoutNature
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
2004
Human cancer, PTEN and the PI-3 kinase pathway
2004
Oncogenic PI3K deregulates transcription and translation
2005
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
2014 StandoutNobel
Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2.
1990
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
2007
PIK3CA Gene Mutations in Pediatric and Adult Glioblastoma Multiforme
2006
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
1996 StandoutNobel
Transferrin receptor 1 in cancer: a new sight for cancer therapy.
2018
Systematic identification of signaling pathways with potential to confer anticancer drug resistance
2014
Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.
1993
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
2010
Breast Cancer–Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells
2005
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.
1992 Standout
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53
2019
CROSS-TALK BETWEEN BACTERIAL PATHOGENS AND THEIR HOST CELLS
1996
Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers
2005
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Palmitylation of neuromodulin (GAP-43) is not required for phosphorylation by protein kinase C.
1992
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
2004
A sulfated metabolite produced bystf3negatively regulates the virulence ofMycobacteriumtuberculosis
2006 StandoutNobel
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Cancer-specific mutations in PIK3CA are oncogenic in vivo
2006
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition
2008
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase
2007
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
2003 StandoutNobel
Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids
1994
1997 StandoutNobel
Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C.
1991
Cancer Genome Landscapes
2013 StandoutScience
Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
1998 Standout
Monocyte responses to sulfatide from Mycobacterium tuberculosis: inhibition of priming for enhanced release of superoxide, associated with increased secretion of interleukin-1 and tumor necrosis factor alpha, and altered protein phosphorylation
1991
A calcium-dependent mechanism for associating a soluble arachidonoyl-hydrolyzing phospholipase A2 with membrane in the macrophage cell line RAW 264.7.
1990
Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase
1979
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.
1993
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
2003
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Role of Ca2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts
1991
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe.
1988
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
1981 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
2008
A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective
2021
YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis
2005
Works of Wayne A. Phillips being referenced
A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
2012
The Ras/Mitogen-Activated Protein Kinase Pathway Inhibitor and Likely Tumor Suppressor Proteins, Sprouty 1 and Sprouty 2 Are Deregulated in Breast Cancer
2004
Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer
2003
PIK3CAmutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor–positive breast cancer
2010
Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.
1989
Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus
2005
Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention
2015
Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
1998
Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
2017
Id2 Is a Target of the β-Catenin/T Cell Factor Pathway in Colon Carcinoma
2001
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.
2001
Effects of colestipol hydrochloride (U-26,597A) on serum and fecal lipids in dogs
1973
Influence of calcium on the subcellular distribution of protein kinase C in human neutrophils
1989
Predicting pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review
2015
Priming the macrophage respiratory burst with IL-4: enhancement with TNF-alpha but inhibition by IFN-gamma.
1990
Role of YopH in the suppression of tyrosine phosphorylation and respiratory burst activity in murine macrophages infected with Yersinia enterocolitica
1995
Mutation of the PIK3CA Gene in Ovarian and Breast Cancer
2004
Microsatellite instability in gastrointestinal tract tumours.
2000
Changes in the Incorporation of Free Fatty Acids Upon the Stimulation of Human Polymorphonuclear Leukocytes
1986
Activation of the respiratory burst in macrophages. Phosphorylation specifically associated with Fc receptor-mediated stimulation.
1988
Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcium ionophore ionomycin. Implications for regulation of the respiratory burst.
1987
Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo
2004
Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica
1994
Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages.
1992
Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A
1991