Citation Impact
Citing Papers
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Eosinophils are a major intravascular location for tissue factor storage and exposure
2006
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
2011 Standout
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
2008 Standout
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
2009 Standout
Polyphosphate modulates blood coagulation and fibrinolysis
2006
Alternative Activation Is an Innate Response to Injury That Requires CD4+ T Cells to be Sustained during Chronic Infection
2007 StandoutNobel
The Role for T Cell Repertoire/Antigen-Specific Interactions in Experimental Kidney Ischemia Reperfusion Injury
2009
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
2021 StandoutNobel
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
2017 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout
2011
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
2010
Ischemia and reperfusion—from mechanism to translation
2011 Standout
mRNA-based dendritic cell vaccines
2014
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome
2012
Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence
2019 StandoutNobel
The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP
2012
Biofilms
2013
Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease
2011
Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP
2011
Simultaneous Activation of Complement and Coagulation by MBL-Associated Serine Protease 2
2007
Macrophage Replication Screen Identifies a Novel Francisella Hydroperoxide Resistance Protein Involved in Virulence
2011
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
The unique role of natural killer T cells in the response to microorganisms
2007
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
2003
Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review
2011
Antibiotics in Canadian poultry productions and anticipated alternatives
2014
Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice
2011
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
2007 StandoutNobel
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
2004
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
2015 Standout
Serotonin and Its Role in Colonic Function and in Gastrointestinal Disorders
2006
Radioembolization with 90Yttrium Microspheres: A State-of-the-Art Brachytherapy Treatment for Primary and Secondary Liver Malignancies
2006
The structural basis for the sensing and binding of cyclic di-GMP by STING
2012
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Crohn's disease
2012 Standout
Effect of Solar Particle Event Radiation and Hindlimb Suspension on Gastrointestinal Tract Bacterial Translocation and Immune Activation
2012 StandoutNobel
Geographic distribution and ecological studies of inflammatory bowel disease in southeastern Norway in 1990–1993
2008
mRNA
2013
c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress
2011
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
2006 StandoutNobel
Melioidosis
2012 Standout
Development of Vaccines Against Burkholderia Pseudomallei
2011
Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
2003
Granulomas in schistosome and mycobacterial infections: a model of local immune responses
2002
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
2012
Immunology and immunotherapy of colorectal cancer
2003
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
2015 Standout
Large-Scale Production of the Immunomodulator c-di-GMP from GMP and ATP by an Enzymatic Cascade
2011
The Functional Gastrointestinal Disorders and the Rome III Process
2006 Standout
Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?
2005
Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome
2003
Specificities of the fecal microbiota in inflammatory bowel disease
2006
Systematic Review and Meta-analysis of the Prevalence of Irritable Bowel Syndrome in Individuals With Dyspepsia
2009
The overlapping host responses to bacterial cyclic dinucleotides
2011
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Clinical trial: the effects of a trans‐galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome
2008
The bacterial second messenger c-di-GMP: mechanisms of signalling
2011
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
Neuroplasticity and dysfunction after gastrointestinal inflammation
2014
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
The Efficacy and Safety of Rifaximin for the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
2011
mRNA transcript therapy
2014 StandoutNobel
Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity
2014
Wound Trauma Increases Radiation-Induced Mortality by Activation of iNOS Pathway and Elevation of Cytokine Concentrations and Bacterial Infection
2010
Enhanced Therapeutic Efficacy of Tumor RNA-Pulsed Dendritic Cells after Genetic Modification with Lymphotactin
1999
Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo
2010
Irritable bowel syndrome in developing countries – a disorder of civilization or colonization?
2005
Regulatory T cells: friend or foe in immunity to infection?
2004
Selective internal radiation therapy (SIRT) for liver metastases secondary to colorectal adenocarcinoma
2006
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
2013
Extracellular mRNA Induces Dendritic Cell Activation by Stimulating Tumor Necrosis Factor-α Secretion and Signaling through a Nucleotide Receptor
2002 StandoutNobel
Prevalence of Symptoms Meeting Criteria for Irritable Bowel Syndrome in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis
2012
Eradication of Helicobacter pylori and Resolution of Gastritis in the Gastric Mucosa of IL‐10‐Deficient Mice
2005
Review article: the role of bacteria in onset and perpetuation of inflammatory bowel disease
2006
Radioembolization with 90Yttrium Microspheres: A State-of-the-Art Brachytherapy Treatment for Primary and Secondary Liver Malignancies
2006
Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review
2005
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
2014
Vα14i NKT Cells Are Innate Lymphocytes That Participate in the Immune Response to Diverse Microbes
2005
Thrombosis as an intravascular effector of innate immunity
2012 Standout
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
2005 Standout
SARS-CoV-2 vaccines in development
2020 StandoutNature
STING is a direct innate immune sensor of cyclic di-GMP
2011 Nature
APD3: the antimicrobial peptide database as a tool for research and education
2015 Standout
Internalization and phagosome escape required forFrancisellato induce human monocyte IL-1β processing and release
2005
Irritable Bowel Syndrome
2015 Standout
Microflora Modulation of Motility
2011
Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets
2014
Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease
2010 Standout
Global trends in antimicrobial use in food animals
2015 Standout
Phenotypic characterization of human colorectal cancer stem cells
2007 Standout
Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome
2012
The Brain-Gut Axis in Abdominal Pain Syndromes
2010
Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice
1999
Pathogenesis ofHelicobacter pyloriInfection
2006 Standout
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
2014
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
2005
Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo
2003 StandoutNobel
Targeted methods for quantitative analysis of protein glycosylation
2014
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
2015
Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII
2013 StandoutNobel
MPYS/STING-Mediated TNF-α, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3′–5′)-Cyclic-Di-Guanosine-Monophosphate In Vivo
2013
Mast Cells, Basophils, and Eosinophils Acquire Constitutive IL-4 and IL-13 Transcripts during Lineage Differentiation That Are Sufficient for Rapid Cytokine Production
2005
Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions
2011
The ecology of the microbiome: Networks, competition, and stability
2015 StandoutScience
Cyclic Di-GMP Stimulates Biofilm Formation and Inhibits Virulence of Francisella novicida
2012
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments
2011
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
2005 Standout
Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency
2010 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Protective Roles for Fibrin, Tissue Factor, Plasminogen Activator Inhibitor-1, and Thrombin Activatable Fibrinolysis Inhibitor, but Not Factor XI, during Defense against the Gram-Negative Bacterium Yersinia enterocolitica
2011
Multivalent Ligand: Design Principle for Targeted Therapeutic Delivery Approach
2012
Chemical Glycoproteomics
2016 StandoutNobel
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science
Works of Wangxue Chen being referenced
Anti-CD25 Antibody-Mediated Depletion of Effector T Cell Populations Enhances Susceptibility of Mice to Acute but Not Chronic Toxoplasma gondii Infection
2009
Dendritic cell‐based cancer immunotherapy: Potential for treatment of colorectal cancer?
2000
Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP
2008
Serum proinflammatory cytokine response in patients with advanced liver tumors following selective internal radiation therapy (SIRT) with 90Yttrium microspheres
2001
The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
2010
Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an αβ T cell- and interferon gamma- dependent mechanism
2004
Detection of Listeria monocytogenes by polymerase chain reaction in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
2000
3′,5′-Cyclic diguanylic acid: a small nucleotide that makes big impacts
2010
c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment
2011
Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice
2011
Activation of the mucosal immune system in irritable bowel syndrome
2002
Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen
2004
Induction of mucosal immunity through systemic immunization: Phantom or reality?
2016
A novel pentamer versus pentamer approach to generating neutralizers of verotoxin 1
2006
Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin‐101
2001
Toll-like receptor 4 (TLR4) plays a relatively minor role in murine defense against primary intradermal infection with Francisella tularensis LVS
2004
Detection of Chlamydia pneumoniae by polymerase chain reaction–enzyme immunoassay in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
2002
Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: Effects of host background and route of immunization
2009
3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection
2009
Exacerbated Susceptibility to Infection-Stimulated Immunopathology in CD1d-Deficient Mice
2005
Fibrin-mediated Protection Against Infection-stimulated Immunopathology
2003
Methylamidation for Sialoglycomics by MALDI-MS: A Facile Derivatization Strategy for Both α2,3- and α2,6-Linked Sialic Acids
2010
Infection-Stimulated Fibrin Deposition Controls Hemorrhage and Limits Hepatic Bacterial Growth during Listeriosis
2005
IL‐4, IL‐5 and IL‐10 are not required for the control of M. bovis‐BCG infection in mice
1998
Distinct Roles of Reactive Nitrogen and Oxygen Species To Control Infection with the Facultative Intracellular BacteriumFrancisella tularensis
2004
Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer.
2001