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Citing Papers
An upstream transcription factor, USF (MLTF), facilitates the formation of preinitiation complexes during in vitro chromatin assembly.
1990
Hallmarks of Cancer: The Next Generation
2011 Standout
Cox-2-Selective Inhibitors: The New Super Aspirins
1999
Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts.
1995
Prostaglandin Endoperoxide H Synthases-1 and -2
1996
Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2
1995
The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release
1998
Cysteine cathepsin proteases as pharmacological targets in cancer
2007
Chromatin as an essential part of the transcriptional mechanim
1992 Nature
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
1995 StandoutNobel
A two stage click-based library of protein tyrosine phosphatase inhibitors
2006
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
1998 Standout
A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors
1996
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding
1993 StandoutNatureNobel
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
1995
Cytosolic Phospholipase A2 Is Required for Cytokine-induced Expression of Type IIA Secretory Phospholipase A2 That Mediates Optimal Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Rat 3Y1 Fibroblasts
1998
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: a new action for an old drug
2001
RSC, an Essential, Abundant Chromatin-Remodeling Complex
1996 StandoutNobel
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Molecular cloning of Drosophila TFIID subunits
1994 Nature
Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.
1997
Activation of Cytosolic Phospholipase A2 by Platelet-derived Growth Factor Is Essential for Cyclooxygenase-2-dependent Prostaglandin E2 Synthesis in Mouse Osteoblasts Cultured with Interleukin-1
1997
Comparison of Structural Stabilities of Prostaglandin H Synthase-1 and -2
1998
Analysis of structure-function relationships of yeast TATA box binding factor TFIID
1990
Crystal structure of the nucleosome core particle at 2.8 Å resolution
1997 StandoutNature
The Interaction of Arginine 106 of Human Prostaglandin G/H Synthase-2 with Inhibitors Is Not a Universal Component of Inhibition Mediated by Nonsteroidal Anti-inflammatory Drugs
1997
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513→ Arg and Ile523→ Val Mutation
1997
Facilitated binding of TATA-binding protein to nucleosomal DNA
1994 Nature
Histone Function in Transcription
1990
Histone Octamer Transfer by a Chromatin-Remodeling Complex
1999 StandoutNobel
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase
1995
Prostaglandin E2 Amplifies Cytosolic Phospholipase A2- and Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Mouse Osteoblastic Cells
1997
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery
2007
Activation of class II gene transcription by regulatory factors is potentiated by a novel activity
1991
Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box
1989 Nature
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II
1991 Science
Prostaglandin endoperoxide synthases-1 and -2
1995
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
1996 Standout
Origin and physiological roles of inflammation
2008 StandoutNature
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
1996 StandoutNature
Effects of activation-defective TBP mutations on transcription initiation in yeast
1994 StandoutNatureNobel
Future directions of bone-targeted therapy for metastatic breast cancer
2010
Histone acetylation in chromatin structure and transcription
1997 StandoutNature
Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes
1991
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
2000 Standout
Role of Nucleosome Remodeling Factor NURF in Transcriptional Activation of Chromatin
1997
Atherosclerosis
2000 StandoutNature
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K
2005
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1
1993 Nature
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors
1990
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
1991 StandoutNature
Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model
1999
COX-2 inhibitors
1999 Standout
A Heparin-sensitive Phospholipase A2 and Prostaglandin Endoperoxide Synthase-2 Are Functionally Linked in the Delayed Phase of Prostaglandin D2 Generation in Mouse Bone Marrow-derived Mast Cells
1996
Mutational Analysis of the Role of the Distal Histidine and Glutamine Residues of Prostaglandin-Endoperoxide Synthase-2 in Peroxidase Catalysis, Hydroperoxide Reduction, and Cyclooxygenase Activation
1997
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
1990 StandoutNobel
Role of cytosolic phospholipase A2 in allergic response and parturition
1997 Nature
Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety
1995
Irresistible force meets immovable object: Transcription and the nucleosome
1991 StandoutNobel
NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.
1992 StandoutNobel
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.
1995 StandoutNobel
A bipartite DNA binding domain composed of direct repeats in the TATA box binding factor TFIID.
1992
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
1996 StandoutNobel
Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)
1990 Nature
Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.
1995 StandoutNobel
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Molecular Cloning, Expression, and Characterization of the Drosophila 85-Kilodalton TFIID Subunit
1993
Cyclooxygenases: Structural, Cellular, and Molecular Biology
2000 Standout
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Differential Effects of Nonsteroidal Anti-Inflammatory Drugs on Constitutive and Inducible Prostaglandin G/H Synthase in Cultured Bone Cells
1997
The role of general initiation factors in transcription by RNA polymerase II
1996
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.
1995
Crystal structure of yeast TATA-binding protein and model for interaction with DNA.
1993 StandoutNobel
cDNA clone encoding Drosophila transcription factor TFIID.
1990
The histone fold: evolutionary questions.
1995 StandoutNobel
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Transcription factor TFIID induces DNA bending upon binding to the TATA element.
1992
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Transcriptional Activation in an Improved Whole-Cell Extract from Saccharomyces cerevisiae
1991
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
1995
Role of Group II Secretory Phospholipase A2in Atherosclerosis
1999
Chromatin Structure and Transcription
1992 StandoutNobel
Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II
1991 Science
Chromatin remodeling by DNA bending, not twisting
2005 StandoutNobel
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
1997 StandoutScience
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Chromatin remodeling by nucleosome disassembly in vitro
2006 StandoutNobel
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.
1992
Transcriptional activation in an improved whole-cell extract from Saccharomyces cerevisiae.
1991
The Kinetic Factors That Determine the Affinity and Selectivity for Slow Binding Inhibition of Human Prostaglandin H Synthase 1 and 2 by Indomethacin and Flurbiprofen
1996
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.
1994
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Activity-Based Profiling of Proteases
2014
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
1994
Cytosolic phospholipase A2is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells
1999
Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.
1992 StandoutNobel
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
1999
Initiation on chromatin templates in a yeast RNA polymerase II transcription system.
1992 StandoutNobel
Structural analysis of the RSC chromatin-remodeling complex
2002 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau).
1992
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Stimulation of Transcription Factor Binding and Histone Displacement by Nucleosome Assembly Protein 1 and Nucleoplasmin Requires Disruption of the Histone Octamer
1995
Works of Wanda Cromlish being referenced
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.
1994
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells
1996
An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells
2004
High-Level Expression of Active Human Cyclooxygenase-2 in Insect Cells
1994
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells
1997
Cloning and Expression of Rat Prostaglandin Endoperoxide Synthase (Cyclooxygenase)-2 cDNA
1993
Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly
1988
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
2004
A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains
1995
The development of potent non-peptidic PTP-1B inhibitors
2004
The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B
2003
Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity
2005
Selective Inhibitors of Cox-2
1995
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
1997
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
1997
Functional Identification of the Active-Site Nucleophile of the Human 85-kDa Cytosolic Phospholipase A2
1996
Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters
1989