Citation Impact
Citing Papers
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
2006 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Features of apoptotic cells measured by flow cytometry
1992 Standout
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Acromegaly
2006 Standout
K-ras Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
2008 Standout
Cell production rates in human tissues and tumours and their significance. Part II: clinical data
2000
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System
2000 StandoutNobel
Molecular Biology of Barrett’s Adenocarcinoma
2001
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, andmdr gene expression in colorectal cancer
1993
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Tumor heterogeneity: Causes and consequences
2009
Head and neck cancer
2008 Standout
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
2010 StandoutNature
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
Esophageal Cancer
2003 Standout
Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
2004 Standout
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 Standout
Colorectal cancer
2013 Standout
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Telomere dysfunction and the initiation of genome instability
2003 StandoutNobel
Hyperfractionated Accelerated Radiotherapy for T1,2 Glottic Carcinoma
2008
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
2010
An interleukin‐1β‐converting enzyme‐like protease is a common mediator of apoptosis in thymocytes
1995
Blinded by the Light: The Growing Complexity of p53
2009 Standout
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
1996 StandoutNobel
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression
2001 StandoutNobel
Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry
1994
Oesophageal carcinoma
2013 Standout
Protease activation during apoptosis: Death by a thousand cuts?
1995 Standout
U1 snRNP regulates cancer cell migration and invasion in vitro
2020 Standout
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications
2012
Differentiating agents in pediatric malignancies: Retinoids in neuroblastoma
2000
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Hereditary Colorectal Cancer
2003 Standout
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Mitochondria and programmed cell death: back to the future
1996
Neuroblastoma
2007 Standout
Clinicopathologic study of 85 similarly treated patients with anaplastic astrocytic tumors
1999
Stem Cells and Cancer
2004 Standout
Quantification of Apoptosis and Necrosis by Flow Cytometry
1993
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
N-acetylcysteine blocks apoptosis induced by N-α-tosyl-L-phenylalanine chloromethyl ketone in transformed T-cells
1999
Predictors of progression in Barrett's esophagus III: baseline flow cytometric variables
2001
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines
1999
Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study
1998
Clonal evolution in cancer
2012 StandoutNature
Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo
1998
The PI3K Pathway in Human Disease
2017 Standout
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Tumour evolution inferred by single-cell sequencing
2011 StandoutNature
Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism
2000
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Brain Tumors
2001 Standout
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer
2006
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
2010
Apoptosis induction resulting from proteasome inhibition
1996
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.
1993 Standout
Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.
1993
miR-34a repression of SIRT1 regulates apoptosis
2008
1p36 Tumor Suppression—A Matter of Dosage?
2012
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
1997 Nature
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
2001
Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
2000
Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
2002 Standout
Mitochondrial Diseases in Man and Mouse
1999 StandoutScience
Alternating chemoradiotherapy versus partly accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck
2001
PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS
1998
Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.
1994
Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells
2002
Microsatellite instability in colorectal cancer
2006
Hereditary Nonpolyposis Colorectal Cancer—Lynch Syndromes I and II
1988
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Role of multiple cellular proteases in the execution of programmed cell death
1995
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Phase I Trial of Oral Fenretinide in Children With High-Risk Solid Tumors: A Report From the Children's Oncology Group (CCG 09709)
2006
Works of Walter Giaretti being referenced
Prognostic significance of nuclear DNA content in human neuroepithelial tumors
1991
Evidence of cell kinetics as predictive factor of response to radiotherapy alone or chemoradiotherapy in patients with advanced head and neck cancer
2000
K‐ras2 Mutation Spectrum, DNA Aneuploidy, and Epithelial Cell Proliferation in Colorectal Adenomasa
1995
Flow cytometric DNA ploidy in colorectal adenomas and family history of colorectal cancer
1988
DNA flow cytometry of endoscopically examined colorectal adenomas and adenocarcinomas
1988
Potential doubling time in head and neck tumors treated by primary radiotherapy: Preliminary evidence for a prognostic significance in local control
1993
Aneuploidy Mechanisms in Human Colorectal Preneoplastic Lesions and Barrett’s Esophagus. Is There a Role for K‐Ras and p53 Mutations?
1997
A New method to discriminate G1, S, G2, M, and G1 postmitotic cells
1989
Flow cytometric DNA index in the prognosis of colorectal cancer
1991
p53 Mutations and DNA Ploidy in Colorectal Adenocarcinomas
1998
Cell kinetics and tumor regression during radiotherapy in head and neck squamous-cell carcinomas
1996
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability
2002
K‐ras2 Activation and Genome Instability Increase Proliferation and Size of FAP Adenomas
1999
In vivo cell kinetics in head and neck squamous cell carcinomas predicts local control and helps guide radiotherapy regimen.
1995
Deletions at chromosome 1p by fluorescence in situ hybridization are an early event in human colorectal tumorigenesis
1996
Neuroblastoma cell apoptosis induced by the synthetic retinoid N‐(4‐hydroxyphenyl)retinamide
1994
Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases.
1992
Combined DNA flow cytometry and sorting with k‐ras2 mutation spectrum analysis and the prognosis of human sporadic colorectal cancer
2002
A model of DNA aneuploidization and evolution in colorectal cancer.
1994
Intratumor Heterogeneity of K‐Ras and p53 Mutations among Human Colorectal Adenomas Containing Early Cancer
2000
Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy.
1996
Chapter 25 Light Scatter of Isolated Cell Nuclei as a Parameter Discriminating the Cell-Cycle Subcompartments
1994
Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.
1992