Standout Papers

Properties of the ts3 mutant of polyoma virus during lytic infection 1970 2026 1988 2007 104
  1. Properties of the ts3 mutant of polyoma virus during lytic infection (1974)
    Walter Eckhart, Renato Dulbecco Virology
  2. Temperature-Dependent Properties of Cells Transformed by a Thermosensitive Mutant of Polyoma Virus (1970)
    Renato Dulbecco, Walter Eckhart Proceedings of the National Academy of Sciences
  3. Temperature-Dependent Surface Changes in Cells Infected or Transformed by a Thermosensitive Mutant of Polyoma Virus (1971)
    Walter Eckhart, Renato Dulbecco et al. Proceedings of the National Academy of Sciences

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Localization of gene functions in polyoma virus DNA.
1976
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1990
Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60c-src
1985
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.
1983
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1986
Polyoma virus transforming protein associates with the product of the c-src cellular gene
1983 Nature
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1989
Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein
1981
Snyder-Theilen feline sarcoma virus P85 contains a single phosphotyrosine acceptor site recognized by its associated protein kinase
1981
Feline sarcoma virus P115-associated protein kinase phosphorylates tyrosine. Identification of a cellular substrate conserved during evolution.
1980
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Characterization of pp85, a target of oncogenes and growth factor receptors.
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Premature p34 cdc2 Activation Required for Apoptosis
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The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.
1984 StandoutNobel
Transformation-defective mutants of Snyder-Theilen feline sarcoma virus lack tyrosine-specific protein kinase activity
1981
The Expression Of Normal Histocompatibility Antigens In Tumor Cells
1973
Identification of a Novel Neuronal C-SRC Exon Expressed in Human Brain
1990
Altered phosphorylation and activation of PP60c-src during fibroblast mitosis
1988
Processing of p60v-src to its myristylated membrane-bound form.
1985
Simian Virus 40 T Antigen Binds to DNA
1974 StandoutNobel
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses
1983
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.
1990
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Sequences in the polyomavirus DNA regulatory region involved in viral DNA replication and early gene expression
1985
Binding of Hepatitis C Virus to CD81
1998 StandoutScienceNobel
Bacterial expression of an enzymatically active protein encoded by RSV src gene
1982 Nature
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation
1987
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein.
1982
The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins
1981
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
1974 StandoutNatureNobel
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.
1989
[42] Detection and quantification of phosphotyrosine in proteins
1983
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
Hr-t and ts-a: Two early gene functions of polyoma virus
1977
Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells
1976 StandoutNatureNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Isolation and Function of the Gene A Initiator of Bacteriophage ϕX 174, A Highly Specific DNA Endonuclease
1974
Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src
1983 StandoutNobel
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.
1990
Protein Synthesis in Simian Virus 40-Infected Monkey Cells
1972 StandoutNobel
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line.
1982
Protein-Tyrosine Kinase Activity in Saccharomyces cerevisiae
1986 Science
Regulation of phosphorylation of the beta-subunit of th Ehrlich ascites tumor Na+K+-ATPase by a protein kinase cascade.
1981
Hydroxyurea-Induced Accumulation of Short Fragments During Polyoma DNA Replication I. Characterization of Fragments
1973
A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity.
1985 StandoutNobel
Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect.
1988
The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells.
1983 StandoutNobel
Constitutive activation of Mek1 by mutation of serine phosphorylation sites.
1994
Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus
1970
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Cytoskeletal association of pp60src
1987
Cell Transformation by Viruses
1969 StandoutScienceNobel
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.
1980 StandoutNobel
Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes
1982
Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cells.
1985
A Protein Tyrosine Kinase Involved in Regulation of pp60c-src function
1989
Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus
1980
Host Range Mutants of Polyoma Virus
1970
Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus.
1982
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.
1981
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction
1996
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product
1980 StandoutNatureNobel
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.
1982
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
1985
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
1990
p53 functions as a cell cycle control protein in osteosarcomas.
1990
Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen
1990
Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53
1992
Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus.
1980
Initiation and maintenance of cell transformation by simian virus 40: a viral genetic property.
1975
Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.
1988
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
1983 StandoutNatureNobel
Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity.
1980
Characterization of the major protein-tyrosine-phosphatases of human placenta.
1988 StandoutNobel
Membrane receptors for murine leukemia viruses: Characterization using the purified viral envelope glycoprotein, gp71
1976
Polyoma virus proteins
1971 StandoutNobel
An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase
1987
The Cellular src Gene Product Regulates Junctional Cell-to-Cell Communication
1988 Science
c-src gene product in developing rat brain is enriched in nerve growth cone membranes.
1988
A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation
1980
A temperature-sensitive mutant of simian virus 40 affecting transforming ability
1973 StandoutNobel
Homologous tyrosine phosphorylation sites in transformation-specific gene products of distinct avian sarcoma viruses
1981 Nature
Proteolysis by Calpains: a Possible Contribution to Degradation of p53
1997
Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice.
1975
Host range selection of transformation-defective hr-t mutants of polyoma virus
1977
Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527.
1988
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine.
1980 StandoutNobel
Temperature-sensitive growth regulation in one type of transformed rat cells induced by the tsa mutant of polyoma virus
1977
Brain-specific src oncogene mRNA mapped in rat brain by in situ hybridization.
1988
Mechanism of Activation of Complexed pp60 c-src by the Middle T Antigen of Polyomavirus
1989
Tyr 527 Is Phosphorylated in pp60 c- src : Implications for Regulation
1986 Science
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
1987
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).
1981 StandoutNobel
A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity
1990
Tyrosine-specific protein kinase activity associated with p105 of avian sarcoma virus PRCII
1981
Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus
1970 StandoutNobel
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability
1989
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
1984
Synthetic peptide fragment of src gene product inhibits the src protein kinase and crossreacts immunologically with avian onc kinases and cellular phosphoproteins.
1981
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
1988
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
1987
Synthetic peptide substrates for a tyrosine protein kinase.
1982
Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine
1980 NatureNobel
Transforming proteins of some feline and avian sarcoma viruses are related structurally and functionally
1981
A phosphotyrosyl‐protein phosphatase activity associated with acid phosphatase from human prostate gland
1984
Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells
1982
Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation
1984
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
1990
Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56lck Tyrosine Protein Kinase
1990
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
1976 StandoutNatureNobel
Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro
1985
Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus
1981 StandoutNobel
Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum.
1987
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus.
1988
Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine
1980 Nature
Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses
1982
The gene H spike protein of bacteriophages ∅X174 and S13
1975
Patterns of Integration of DNA Microinjected into Cultured Mammalian Cells: Evidence for Homologous Recombination Between Injected Plasmid DNA Molecules
1982 StandoutNobel
Csk suppression of Src involves movement of Csk to sites of Src activity.
1994
Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src of Prague Rous sarcoma virus
1986
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
1979
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.
1989
Phosphorylation of the beta subunit of Na+K+-ATPase in Ehrlich ascites tumor by a membrane-bound protein kinase.
1980
A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein.
1981 StandoutNobel
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.
1989
Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells.
1988
Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.
1988 StandoutNobel
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.
1987
Three species of polyoma virus tumor antigens share common peptides probably near the amino termini of the proteins
1978
Organization of the Genomes of Polyoma Virus and SV40
1977
[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
1991
Characterization of the altered form of the c-src gene product in neuronal cells.
1987
Rous Sarcoma Virus: a Function required for the Maintenance of the Transformed State
1970 Nature
In Vitro Polyoma DNA Synthesis: Characterization of a System from Infected 3T3 Cells
1974
Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart.
1983
Identification of phosphotyrosine in yeast proteins and of a protein tyrosine kinase associated with the plasma membrane.
1985
Induction of Mitochondrial DNA Synthesis by Polyoma Virus
1971 Nature
Interferon-sensitivity of the enhanced incorporation of thymidine into cellular DNA induced by polyoma virus
1970 StandoutNobel
Rapid activation of sodium–proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT1A receptor involves distinct signalling cascades
1998
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.
1986
Virus-specific proteins in the plasma membrane of cells lytically infected or transformed by pol-oma virus.
1977 Nobel
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes.
1982
Synthesis of Superhelical Simian Virus 40 Deoxyribonucleic Acid in Cell Lysates*
1975 StandoutNobel
Unusual Fragments in the Subunit Structure of Concanavalin A
1971 StandoutNobel
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells
1981
Stable Association of Activated pp60src with Two Tyrosine-Phosphorylated Cellular Proteins
1989
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
1980 Standout
Purified EGF receptor–kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein
1981 StandoutNatureNobel
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.
1983 StandoutNobel
Immunocytochemical localization of the neuron-specific form of the c- src gene product, pp60c-src(+), in rat brain
1990
Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.
1985
New region of the simian virus 40 genome required for efficient viral transformation.
1978 StandoutNobel
Mutants of Fujinami sarcoma virus which are temperature sensitive for cellular transformation and protein kinase activity
1981
DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.
1995
Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.
1996 Nobel
The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.
1988
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.
1988
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).
1981 StandoutNobel
Restriction of the In Vitro and In Vivo Tyrosine Protein Kinase Activities of pp60c-src Relative to pp60v-src
1985
The amino terminus of polyomavirus middle T antigen is required for transformation
1990
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
1990 StandoutScience
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
1985 Nature
Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.
1988
Nucleotide sequence of bacteriophage φX174 DNA
1977 StandoutNatureNobel
A mouse homolog to the avian sarcoma virus src protein is a member of a protein kinase cascade
1981
Selective dephosphorylation of proteins containing phosphotyrosine by alkaline phosphatases.
1981 StandoutNobel

Works of Walter Eckhart being referenced

Complementation between temperature-sensitive (ts) and host range nontransforming (hr-t) mutants of polyoma virus
1977
Nucleotide sequence of a cDNA encoding the monkey cellular phosphoprotein p53
1989
Cell Transformation by Polyoma Virus and SV40
1969 Nature
Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain
1987
The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker
1981
Phosphorylation of p53 in Normal and Simian Virus 40-Transformed NIH 3T3 Cells
1988
N-Terminal Amino Acid Sequences of the Polyoma Middle-Size T Antigen Are Important for Protein Kinase Activity and Cell Transformation
1984
Construction and Expression of a Recombinant DNA Gene Encoding a Polyomavirus Middle-Size Tumor Antigen with the Carboxyl Terminus of the Vesicular Stomatitis Virus Glycoprotein G
1984
Complexes of polyoma virus medium T antigen and cellular proteins.
1985
pp60c-src expression in the developing rat brain.
1988
p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen
1988
Characterization of t antigens in polyoma-infected and transformed cells
1978
cDNA cloning with a retrovirus expression vector: generation of a pp60c-src cDNA clone
1987
Temperature-Dependent Surface Changes in Cells Infected or Transformed by a Thermosensitive Mutant of Polyoma Virus
1971 StandoutNobel
Altered Sites of Tyrosine Phosphorylation in pp60c-src Associated with Polyomavirus Middle Tumor Antigen
1986
Truncated forms of the polyomavirus middle T antigen can substitute for the small T antigen in lytic infection
1986
Partially transformed T3T3 cells express high levels of mutant p53 in the 'wild-type' immunoreactive form with defective oligomerization.
1993
Structural and Functional Modification of pp60c-src Associated with Polyoma Middle Tumor Antigen from Infected or Transformed Cells
1985
Purification of polyoma virus medium-size tumor antigen by immunoaffinity chromatography.
1982
Qualitative and quantitative interactions of lectins with untreated and neuraminidase-treated normal, wild-type, and temperature-sensitive polyoma-transformed fibroblasts
1975
Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.
1988
Properties of Temperature-sensitive Mutants of Polyoma Virus
1974
Mutation causing premature termination of the polyoma virus medium T antigen blocks cell transformation
1982
Polyoma T antigen synthesis by temperature-sensitive mutants of polyoma virus
1972
Complementation and transformation by temperature-sensitive mutants of polyoma virus
1969
Polyoma gene function required for viral DNA synthesis
1973
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates
1979
Polyomavirus middle T protein encoded by a retrovirus transforms nonestablished chicken embryo cells
1985
Mutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo
1990
Polyoma middle-sized T antigen can be phosphorylated on tyrosine at multiple sites in vitro.
1984
GENETICS OF DNA TUMOR VIRUSES
1974
Structural and functional modification of pp60c-src associated with polyoma middle tumor antigen from infected or transformed cells.
1985
Alterations in pp60c-src Accompany Differentiation of Neurons from Rat Embryo Striatum
1987
Temperature-Dependent Properties of Cells Transformed by a Thermosensitive Mutant of Polyoma Virus
1970 StandoutNobel
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.
1986
Construction and expression of a recombinant DNA gene encoding a polyomavirus middle-size tumor antigen with the carboxyl terminus of the vesicular stomatitis virus glycoprotein G.
1984
The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
1990
Phosphorylation sites in the amino-terminal region of mouse p53.
1992
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus
1980
Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.
1992
Properties of the ts3 mutant of polyoma virus during lytic infection
1974 StandoutNobel
N-terminal amino acid sequences of the polyoma middle-size T antigen are important for protein kinase activity and cell transformation.
1984
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.
1990
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