Citation Impact
Citing Papers
NSAID use and dementia risk in the Cardiovascular Health Study*
2007
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
2006
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
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Interactions between APP secretases and inflammatory mediators
2008
Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
2005
Mitochondria take center stage in aging and neurodegeneration
2005
Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau
2004
Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?
2004
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
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Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
2009
Synapses and Alzheimer's Disease
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A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model
2005
Inflammatory processes in Alzheimer's disease
2007
Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity
2003
3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate β-Amyloid-Induced Microglial Inflammatory Responses
2005
Is there a future for vaccination as a treatment for Alzheimer's disease?
2003
Systemic infections and inflammation affect chronic neurodegeneration
2007
Chemopreventive and therapeutic effects of curcumin
2004
Different pathways for iNOS‐mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression
2002
Microglial senescence: does the brain's immune system have an expiration date?
2006
Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
2006
Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies
2007
Mechanisms Underlying Inflammation in Neurodegeneration
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Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
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Ibuprofen-like activity in extra-virgin olive oil
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Age-Related Macular Degeneration
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Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
2002
Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin
2009
Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice
2001
Calpain and caspase: can you tell the difference?
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Inflammation in Neurodegenerative Disease—A Double-Edged Sword
2002
Foundation models for generalist medical artificial intelligence
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Dietary Polyphenols and the Prevention of Diseases
2005 Standout
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
2006
Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease
2003
A century-old debate on protein aggregation and neurodegeneration enters the clinic
2006 Nature
Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein
2002
Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal
2008
Balancing Acts
2004 Standout
A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
2009
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
2001 Nature
The Non-cyclooxygenase Targets of Non-steroidal Anti-inflammatory Drugs, Lipoxygenases, Peroxisome Proliferator-activated Receptor, Inhibitor of κB Kinase, and NFκB, Do Not Reduce Amyloid β42 Production
2003
A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes
2002
IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior
2015
Morphologic and biochemical hallmarks of apoptosis
2000
Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
2001
Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
2000
Modulation of Nuclear Factor-κB Activity by Indomethacin Influences Aβ Levels but Not Aβ Precursor Protein Metabolism in a Model of Alzheimer's Disease
2004
In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
1998
Multiple sclerosis
2008 Standout
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
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Glutamate neurotoxicity and diseases of the nervous system
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Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
2000 StandoutNobel
Complementary inhibition of synoviocyte, smooth muscle cell or mouse lymphoma cell proliferation by a vanadyl curcumin complex compared to curcumin alone
2004
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
2004 Standout
The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease
2003
Neurodegeneration and Inflammation
2008
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
2008
Protein aggregation diseases: pathogenicity and therapeutic perspectives
2010
Chronic nicotine treatment reduces β‐amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
2002
Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
2007
Deletion of the Prostaglandin E2EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease
2005
Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice
2012
Nuclear receptor peroxisome proliferator‐activated receptor‐γ is activated in rat microglial cells by the anti‐inflammatory drug HCT1026, a derivative of flurbiprofen
2005
From endoplasmic-reticulum stress to the inflammatory response
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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
2001
Alzheimer's disease
2006 Standout
Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease
2004
Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
2004
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
2000
Estrogen Modulates Neuronal Bcl‐xl Expression and β‐Amyloid‐Induced Apoptosis
1999
Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease<subtitle>A Randomized Controlled Trial</subtitle>
2009
Microglia and Alzheimer's disease pathogenesis
2004
Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia
2001
Alzheimer's Disease
2010 Standout
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
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Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site
2004
Mechanisms and Functions of Inflammasomes
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Role of toll-like receptor signalling in A uptake and clearance
2006
The Amyloid State of Proteins in Human Diseases
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Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
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Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice
2012
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015
Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP‐1 and NFκB transcription factors
2007
Lack of Specific Amyloid-β(1-42) Suppression by Nonsteroidal Anti-Inflammatory Drugs in Young, Plaque-Free Tg2576 Mice and in Guinea Pig Neuronal Cultures
2004
Role of Free Radicals in the Neurodegenerative Diseases
2001 Standout
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation
2003
Production and Actions of Estrogens
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Microglial EP2 as a New Target to Increase Amyloid β Phagocytosis and Decrease Amyloid β-Induced Damage to Neurons
2006
The Hallmarks of Aging
2013 Standout
Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice
2005
Alzheimer's Disease
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CURCUMIN: THE INDIAN SOLID GOLD
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Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease
2005
Dynamic Complexity of the Microglial Activation Response in Transgenic Models of Amyloid Deposition: Implications for Alzheimer Therapeutics
2005
Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid
2005
A role for local inflammation in the formation of drusen in the aging eye
2002
The role of microglia in amyloid clearance from the AD brain
2010
Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model
2004
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease
2004
Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo
2004
Frailty in elderly people
2013 Standout
Pathways towards and away from Alzheimer's disease
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Molecular Mechanisms of Amyloidosis
2003 Standout
Curry Consumption and Cognitive Function in the Elderly
2006
Overexpression of Monocyte Chemotactic Protein-1/CCL2 in β-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse β-Amyloid Deposition
2005
Peripheral Treatment with Enoxaparin, a Low Molecular Weight Heparin, Reduces Plaques and β-Amyloid Accumulation in a Mouse Model of Alzheimer's Disease
2004
Curcumin: From ancient medicine to current clinical trials
2008 Standout
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Curcumin Activates Defensive Genes and Protects Neurons Against Oxidative Stress
2006
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
2003
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
2005 Standout
The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
2012
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering
2013 StandoutScience
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice
2004
Extending the Nested Model for User-Centric XAI: A Design Study on GNN-based Drug Repurposing
2022
Anticancer potential of curcumin: preclinical and clinical studies.
2003 Standout
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways
2002
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
2003
Curcumin Inhibits Platelet-Derived Growth Factor–Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima Formation
2005
Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimer's disease treatment
2013
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Inflammation as a central mechanism in Alzheimer's disease
2018 Standout
Comparison of Anti‐inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid‐independent Pathway Mediated by Curcuma phaeocaulis Extract
2006
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits
2006
Reduction of amyloid load and cerebral damage in transgenic mouse model of Alzheimer's disease by treatment with a β‐sheet breaker peptide
2002
Reduced incidence of AD with NSAID but not H2receptor antagonists
2002
Modulation of β‐amyloid metabolism by non‐steroidal anti‐inflammatory drugs in neuronal cell cultures
2003
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease
2003
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
2004
Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidylinositol kinase inhibitor wortmannin
2000
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
2003
Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease
2003
Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models
2004
Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice
2002
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.
2003
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
2004
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho
2003 Science
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Works of Walter Beech being referenced
Selective inhibition of Aβ42 production by NSAID R‐enantiomers
2002
GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals
2008
-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin
2009
Effect of chloroquine and leupeptin on intracellular accumulation of amyloid‐beta (Aβ) 1–42 peptide in a murine N9 microglial cell line
1998
Lipoprotein effects on aβ accumulation and degradation by microglia in vitro
1999
The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse
2001
Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
2000
Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.
1998