Citation Impact
Citing Papers
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
2010 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Mega-scale experimental analysis of protein folding stability in biology and design
2023 Nature
Diffraction-unlimited all-optical imaging and writing with a photochromic GFP
2011 StandoutNatureNobel
Structural Mechanisms for Domain Movements in Proteins
1994
Polar and nonpolar atomic environments in the protein core: Implications for folding and binding
1994
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1
1994
Automated design of the surface positions of protein helices
1997
Engineering and characterization of a superfolder green fluorescent protein
2005 Standout
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Forces stabilizing proteins
2014
What are the dielectric “constants” of proteins and how to validate electrostatic models?
2001
Directed enzyme evolution
2001 StandoutNobel
Automated design of specificity in molecular recognition
2002
Studies on Protein Stability With T4 Lysozyme
1995
How Protein Stability and New Functions Trade Off
2008
Halogenated Benzenes Bound within a Non-polar Cavity in T4 Lysozyme Provide Examples of I⋯S and I⋯Se Halogen-bonding
2008
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Exploring steric constraints on protein mutations using MAGE/PROBE
2000
Thoroughly sampling sequence space: Large‐scale protein design of structural ensembles
2002
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Hyperthermostable Variants of a Highly Thermostable Alpha-Amylase
1992
Evolution of an Antibiotic Resistance Enzyme Constrained by Stability and Activity Trade-offs
2002
Structural Bases of Stability–function Tradeoffs in Enzymes
2002
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites
1998 StandoutNobel
Systematic mutation of bacteriophage T4 lysozyme
1991
Computational protein design
1999
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Designed Armadillo Repeat Proteins as General Peptide-Binding Scaffolds: Consensus Design and Computational Optimization of the Hydrophobic Core
2008
Contribution of Hydrophobic Interactions to Protein Stability
2011
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
2022
Relationship between Ion Pair Geometries and Electrostatic Strengths in Proteins
2002
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
CPMG relaxation dispersion NMR experiments measuring glycine 1Hα and 13Cα chemical shifts in the ‘invisible’ excited states of proteins
2009
On/off blinking and switching behaviour of single molecules of green fluorescent protein
1997 StandoutNatureNobel
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Analysis of the effectiveness of proline substitutions and glycine replacements in increasing the stability of phage T4 lysozyme
1992
Mutations that significantly change the stability, flexibility and quaternary structure of the l‐lactate dehydrogenase from Bacillus megaterium
1993
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
1993 Science
Access of ligands to cavities within the core of a protein is rapid
1996
Lessons from the lysozyme of phage T4
2010
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Design of λ Cro Fold: Solution Structure of a Monomeric Variant of the De Novo Protein
2005
Dynamics of biochemical and biophysical reactions: insight from computer simulations
2001 StandoutNobel
Sequence determinants of thermodynamic stability in a WW domain—An all‐β‐sheet protein
2009
The Rough Energy Landscape of Superfolder GFP Is Linked to the Chromophore
2007
Structural Basis of the Enhanced Stability of a Mutant Ribozyme Domain and a Detailed View of RNA–Solvent Interactions
2001 Nobel
De novo proteins from designed combinatorial libraries
2004
Functional rapidly folding proteins from simplified amino acid sequences
1997 StandoutNobel
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Coupling backbone flexibility and amino acid sequence selection in protein design
1997
A surprising simplicity to protein folding
2000 StandoutNatureNobel
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Glyceraldehyde-3-phosphate dehydrogenase fromThermotoga maritima: Strategies of protein stabilization
1996
Simulating enzyme reactions: Challenges and perspectives
2001
Prediction of functionally important residues based solely on the computed energetics of protein structure 1 1Edited by B. Honig
2001
Structure and Stability of Hyperstable Proteins: Glycolytic Enzymes From Hyperthermophilic Bacterium Thermotoga Maritima
1996
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core
1991 StandoutNatureNobel
Development of an in vivo method to identify mutants of phage T4 lysozyme of enhanced thermostability
1993
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
De novo design of the hydrophobic cores of proteins
1995
Missense meanderings in sequence space: a biophysical view of protein evolution
2005
RosettaHoles: Rapid assessment of protein core packing for structure prediction, refinement, design, and validation
2008 StandoutNobel
The Roles of Ribosomal Proteins in the Structure Assembly, and Evolution of the Large Ribosomal Subunit
2004 StandoutNobel
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
1997 StandoutNatureNobel
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
The Backrub Motion: How Protein Backbone Shrugs When a Sidechain Dances
2006
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
De Novo Design of Foldable Proteins with Smooth Folding Funnel
2003
De NovoDesign of Helical Bundles as Models for Understanding Protein Folding and Function
2000
Volume changes in protein evolution
1994
Reconstructing NMR Spectra of “Invisible” Excited Protein States Using HSQC and HMQC Experiments
2002
Computational method to reduce the search space for directed protein evolution
2001 StandoutNobel
Flexibility and Ligand Exchange in a Buried Cavity Mutant of T4 Lysozyme Studied by Multinuclear NMR
2000
Energetics and Dynamics of Enzymatic Reactions
2001 StandoutNobel
Experimental Determination of the Absolute Enantioselectivity of an Antibody-Catalyzed Diels−Alder Reaction and Theoretical Explorations of the Origins of Stereoselectivity
2003
What Is So Special about Arg 55 in the Catalysis of Cyclophilin A? Insights from Hybrid QM/MM Simulations
2003
De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities
2019
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
Evolution of a Protein Fold in Vitro
1999 Science
Crystal Structure of the Aequorea victoria Green Fluorescent Protein
1996 StandoutScienceNobel
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
Directed evolution of a thermostable esterase
1998 StandoutNobel
A cation binding motif stabilizes the compound I radical of cytochrome c peroxidase.
1994
COMPUTER-BASED DESIGN OF NOVEL PROTEIN STRUCTURES
2005
Ser o no ser
2001
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Illuminating Single Molecules in Condensed Matter
1999 StandoutScienceNobel
Molecular breeding: The natural approach to protein design
2001
The Energetics of Hydrogen Bonds in Model Systems: Implications for Enzymatic Catalysis
1996 Science
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Engineering an enzyme to resist boiling
1998
Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies
1997
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Cholesterol and the Golgi Apparatus
1993 Science
Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.
1993 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Protein topology and stability define the space of allowed sequences
2002 StandoutNobel
Directed evolution methods for overcoming trade‐offs between protein activity and stability
2019
Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids
2018
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells
1998 StandoutScienceNobel
Stability for Function Trade-Offs in the Enolase Superfamily “Catalytic Module”,
2007
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds
1996 StandoutNobel
Works of W.A. Baase being referenced
A mutant T4 lysozyme (Val 131 → Ala) designed to increase thermostability by the reduction of strain within an α‐helix
1990
A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene
1992 Nature
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme
1991
Structural and thermodynamic analysis of the packing of two α-helices in bacteriophage T4 lysozyme
1991
Toward a simplification of the protein folding problem: a stabilizing polyalanine .alpha.-helix engineered in T4 lysozyme
1991
Similar Hydrophobic Replacements of Leu99 and Phe153 within the Core of T4 Lysozyme Have Different Structural and Thermodynamic Consequences
1993
Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3 → Pro
1992
Multiple alanine replacements within α‐helix 126–134 of T4 lysozyme have independent, additive effects on both structure and stability
1992
Structural and Genetic Analysis of Electrostatic and Other Interactions in Bacteriophage T4 Lysozyme
2007
A relationship between protein stability and protein function.
1995
Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence.
1992
Disulfide bonds and thermal stability in T4 lysozyme.
1988
Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect
1992 Science
Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants.
1989
The Role of Backbone Flexibility in the Accommodation of Variants That Repack the Core of T4 Lysozyme
1993 Science
A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.
1996