Standout Papers
- Mitochondrial DNA sequences from Switzerland reveal striking homogeneity of European populations. (1994)
- Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein. (1986)
- A rapid, sensitive, and specific method for the determination of protein in dilute solution (1973)
- Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing (1978)
- Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector (1983)
- DNA sequences coding for the H2B histone of Psammechinus miliaris (1977)
- Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor (1976)
Citation Impact
Citing Papers
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1
1991
Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation
1990
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
1991 StandoutNature
New type of POU domain in germ line-specific protein Oct-4
1990 Nature
G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.
1989 StandoutNobel
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
The Role of a Repetitive Palindromic Sequence Element in the Human Cytomegalovirus Major Immediate Early Enhancer
1989
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation
1988
RNA polymerase II C-terminal domain required for enhancer-driven transcription
1995 Nature
Functional reconstitution and characterization of AqpZ, the E. coli water channel protein
1999 StandoutNobel
Angiogenic Signalling Pathways
2008
A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells
1988 Nature
Regulation of transcription and cell identity by POU domain proteins
1991 StandoutNobel
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
1990 Nature
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
Identification of the predominant substrate for ADP-ribosylation by islet activating protein.
1983 StandoutNobel
Ca2+-stimulated ribonucleases from rat mammary gland and R3230AC mammary adenocarcinoma nuclei
1977
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.
1983
Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.
1982 StandoutNobel
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism
1986
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.
1981 StandoutNobel
cis and trans activation of globin gene transcription in transient assays.
1983
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker
1981
Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance
1985
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.
1984 StandoutNobel
Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli
2001 StandoutNobel
Identification of a purified complement-fixing antigen as the Epstein-Barr-virus determined nuclear antigen (EBNA) by its binding to metaphase chromosomes.
1977 StandoutNobel
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.
1990 StandoutNobel
Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.
1985 StandoutNobel
In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers.
1987
Close Is Not Enough
2000 StandoutNobel
Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer
1986 Nature
Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.
1996 StandoutNobel
Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits.
1989
Snarepins Are Functionally Resistant to Disruption by Nsf and αSNAP
2000
The structure and evolution of the human β-globin gene family
1980
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 Standout
An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens
1985
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
1993 StandoutNobel
The 19-kDa glycoprotein coded by region E3 of adenovirus. Purification, characterization, and structural analysis.
1985
A C-terminal signal prevents secretion of luminal ER proteins
1987 Standout
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
1976 Standout
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
High-Frequency Transfer of Cloned Herpes Simplex Virus Type 1 Sequences to Mammalian Cells by Protoplast Fusion
1981
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.
1982 StandoutNobel
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
1986 StandoutNobel
The structure of one of the eight or more distinct chromosomal genes for human interferon-α
1980 Nature
Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products
1983
High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.
1981
Mammalian .beta.2-adrenergic receptor: purification and characterization
1984 StandoutNobel
Expression of Gsα in Escherichia coli
1989 StandoutNobel
The Oct-2 protein binds cooperatively to adjacent octamer sites.
1989
The regulatory component of adenylate cyclase. Purification and properties.
1981 StandoutNobel
Expression and characterization of calmodulin-activated (type I) adenylylcyclase
1991 StandoutNobel
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.
1983 StandoutNobel
Sequence organization of a cloned tDNA1met fragment from xenopus laevis
1978 StandoutNobel
Splicing and the formation of stable RNA
1979
Simian virus 40 enhancer increases number of RNA polymerase II molecules on linked DNA
1985 Nature
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum
1982 StandoutNatureNobel
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
1981
Cloning of an immunoglobulin variable region gene from mouse embryo.
1977 StandoutNobel
The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.
1990
Chicken liver ribosomes: Characterization of cross-reaction and inhibition of some functions by antibodies prepared against Escherichia coli ribosomal proteins L7 and L12
1976
Immunoglobulin gene transcription is activated by downstream sequence elements
1983 Nobel
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase
1983 StandoutNatureNobel
Lipid modifications of G protein subunits.
1991 StandoutNobel
The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.
1986
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma
1992 StandoutNobel
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
1986 StandoutNobel
The SV40 TC-II(kappa B) enhanson binds ubiquitous and cell type specifically inducible nuclear proteins from lymphoid and non-lymphoid cell lines.
1989
The SV40 TC-II(kappa B) and the related H-2Kb enhansons exhibit different cell type specific and inducible proto-enhancer activities, but the SV40 core sequence and the AP-2 binding site have no enhanson properties.
1989
Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.
1986 StandoutNobel
Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ
1977 StandoutScience
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA.
1984 StandoutNobel
How do different transcription factors binding the same DNA sequence sort out their jobs?
1989
Three Functional Classes of Transcriptional Activation Domains
1996
Physical separation of the catalytic and regulatory proteins of hepatic adenylate cyclase.
1981
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.
1983 StandoutNobel
Purification of the regulatory component of adenylate cyclase.
1980 StandoutNobel
19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-
1991 StandoutNobel
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
1984
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Functional reconstitution of beta-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase.
1982
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
1986 StandoutNobel
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.
1984 StandoutNobel
Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G q
1991 Science
Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production
1983 Nature
Multiple sequence motifs are involved in SV40 enhancer function.
1986
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
1979 Standout
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.
1982 StandoutNobel
Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.
1981 StandoutNobel
A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum
1987 StandoutNobel
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein
1987
Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits
1993
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.
1986 StandoutNobel
Disassembly and reconstitution of signal recognition particle
1983 StandoutNobel
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
1994 StandoutNobel
Human fibroblast interferon gene lacks introns
1981
The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription.
1990
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
1987 Standout
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.
1984 StandoutNobel
An inducible transcription factor activates expression of human immunodeficiency virus in T cells
1987 StandoutNatureNobel
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.
1982
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.
1983 StandoutNobel
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.
1983 StandoutNobel
Abrogation of cell surface expression of human class I transplantation antigens by an adenovirus protein in Xenopus laevis oocytes.
1985
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
1984 Standout
Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose.
1987
In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer.
1987
Genetic Transformation of Drosophila with Transposable Element Vectors
1982 StandoutScience
Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences
1984 StandoutNobel
Affinity chromatography of human platelet α 2 -adrenergic receptors
1982 StandoutNobel
Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.
1991
G protein gamma subunits contain a 20-carbon isoprenoid.
1990 StandoutNobel
Works of W. Schaffner being referenced
Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1.
2001
A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position.
1990
A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus.
1985
Direct transfer of cloned genes from bacteria to mammalian cells.
1980
Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.
1988
Metal binding ‘finger’ structures in the glucocorticoid receptor defined by site-directed mutagenesis.
1988
Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein.
1986 StandoutNobel
Transformation of frog embryos with a rabbit beta-globin gene.
1981
Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).
1988
Correct transcription of a cloned mouse immunoglobulin gene in vivo.
1983
A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.
1987
Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.
1992
Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.
1987
A transcription enhancer in the Herpesvirus saimiri genome.
1985
Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.
1990
Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor
1976 StandoutNobel
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
1985
Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter.
1989
Analysis of the Transcriptional Enhancer Effect
1983
Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector
1983 StandoutNobel
Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing
1978 StandoutNobel
Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.
1993
A rapid, sensitive, and specific method for the determination of protein in dilute solution
1973 Standout
Metal-dependent SV40 viruses containing inducible enhancers from the upstream region of metallothionein genes.
1985
Mitochondrial DNA sequences from Switzerland reveal striking homogeneity of European populations.
1994 StandoutNobel
Cell-type preference of immunoglobulin kappa and lambda gene promoters.
1985
The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity.
1987