Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation
2004 StandoutNobel
TOR Signaling in Growth and Metabolism
2006 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
G Protein-coupled Receptor Kinase and β-Arrestin-mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics
2006 StandoutNobel
Analysis of the genome to personalize therapy for melanoma
2010
Role of p21WAF1/CIP1 as an attenuator of both proliferative and drug-induced apoptotic signals in BCR-ABL-transformed hematopoietic cells
2007
p53: traffic cop at the crossroads of DNA repair and recombination
2005
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
1989 Science
The mTOR pathway and its role in human genetic diseases
2008
Regulation of phospholipase D by phosphorylation-dependent mechanisms
1999
Mammalian phospholipase D structure and regulation
1999
Metabolic effects of short‐chain ceramide and glucosylceramide on sphingolipids and protein kinase C
1992
Bidirectional Transport by Distinct Populations of COPI-Coated Vesicles
1997 StandoutNobel
Bcr–Abl variants: biological and clinical aspects
2002
KSR, a novel protein kinase required for RAS signal transduction
1995
p21/CDKN1A Mediates Negative Regulation of Transcription by p53
2003
Molecular Events Mediating T Cell Activation
1990
Disappearance of diacylglycerol kinase translocation in ras-transformed cells
1988
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Receptor-mediated action of hepoxilin A3 releases diacylglycerol and arachidonic acid from human neutrophils
1990 StandoutNobel
Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation
1996
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
p21 in cancer: intricate networks and multiple activities
2009 Standout
Control of Protein Exit from the Endoplasmic Reticulum
1989
Bilayer curvature and certain amphipaths promote poly(ethylene glycol)-induced fusion of dipalmitoylphosphatidylcholine unilamellar vesicles
1992
[10] Assays for G-protein regulation of phospholipase C activity
1994
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species
1997
Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis
2003 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles
1995
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis
1997 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells
1988
Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA
1997
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation
1993 Nature
Mevalonate pathway: A review of clinical and therapeutical implications
2007
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
2006
Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils
1991
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
1997
Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells.
1992
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.
1988
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.
1991
The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor
1992 StandoutNobel
Distinct processes mediate glycoprotein and glycopeptide export from the endoplasmic reticulum in Saccharomyces cerevisiae.
1992 StandoutNobel
Ceramide regulates oxidant release in adherent human neutrophils
1994
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
1987
Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
1991
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
2002
Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.
1990
Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatization and h.p.l.c. separation
1993
Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.
1988
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.
1994
Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.
1992
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.
1996
Diacylglycerol metabolism in mast cells. Analysis of lipid metabolic pathways using molecular species analysis of intermediates.
1987
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes
2008 StandoutNobel
Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
1997 StandoutNobel
Stimulus-response coupling in insulin-secreting HIT cells. Effects of secretagogues on cytosolic Ca2+, diacylglycerol, and protein kinase C activity.
1990
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils
1989
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ
1996
Glycolipid and glycoprotein transport through the Golgi complex are similar biochemically and kinetically. Reconstitution of glycolipid transport in a cell free system.
1990
Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by FcγRs in human neutrophils
1993
Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.
1990
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.
1991
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
1989
The regulation and cellular functions of phosphatidylcholine hydrolysis
1990
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation
1999 StandoutNobel
Quantitative Changes in Polyphosphoinositides 1,2-Diacylglycerol and Inositol 1,4,5-Trisphosphate by Platelet-derived Growth Factor and Prostaglandin F2α
1989
Transcriptional control of human p53-regulated genes
2008 Standout
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation
1989
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
1991
Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts
1990
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner.
1994
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
1990
Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.
1990
Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation.
1987
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTPγS-stimulated polymorphonuclear leukocytes
2003 StandoutNobel
Intracellular Ca2+ and protein kinase C interact to regulate alpha 1-adrenergic- and bradykinin receptor-stimulated phospholipase A2 activation in Madin-Darby canine kidney cells
1991
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Targeting Signal Transduction Pathways in Colorectal Cancer—More Than Skin Deep
2005
Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota
2008
Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1997 StandoutNobel
Optical trapping and manipulation of neutral particles using lasers
1997 StandoutNobel
Cloning and expression of multiple protein kinase C cDNAs
1986
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Mitochondria and Apoptosis
1998 StandoutScience
Multiphasic generation of diacylglycerol in thrombin-activated human platelets
1992
Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.
1992
Generation of Calcium Oscillations in Fibroblasts by Positive Feedback Between Calcium and IP 3
1991 StandoutScienceNobel
Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.
1992
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
1994 StandoutNobel
Involvement of Protein Kinase C in Platelet-activating Factor-stimulated Diacylglycerol Accumulation in Murine Peritoneal Macrophages
1989
Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes
1989
Molecular mechanisms of resistance of leukemia to imatinib mesylate
2003
Ligand-induced overexpression of a constitutively active β 2 -adrenergic receptor: Pharmacological creation of a phenotype in transgenic mice
1997 StandoutNobel
Calcium-dependent activation of protein kinase C. The role of the C2 domain in divalent cation selectivity.
1993
Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System
1992 Science
Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex
1998
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division
2003 StandoutScienceNobel
On the Biological Occurrence and Regulation of 1-Acyl and 1-O-Alkyl-diradylglycerols in Human Neutrophils
1989
A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.
1992
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Response : Nitric Oxide and Arginine-Evoked Insulin Secretion
1992 StandoutScienceNobel
Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes
1989
Works of W. Robert Bishop being referenced
Thematic review series: Lipid Posttranslational Modifications. Farnesyl transferase inhibitors
2005
Enzymatic quantification of sphingosine in the picomole range in cultured cells
1989
Novel Tricyclic Inhibitors of Farnesyl Protein Transferase
1995
The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling
2005
Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules
2000
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
2002
Assembly of Phospholipids into Cellular Membranes: Biosynthesis, Transmembrane Movement and Intracellular Translocation
1988
Differential effects of cell cycle regulatory protein p21WAF1/Cip1 on apoptosis and sensitivity to cancer chemotherapy
2003
K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors
1997
Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I
1997
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
2003
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors
1990
Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.
1991
Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.
1993
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.
1986
Identification and Characterization of Zinc Binding Sites in Protein Kinase C
1991 Science
Ceramide quantitation: evaluation of a mixed micellar assay using E. coli diacylglycerol kinase.
1995
Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation.
1994
Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.
1991
Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets.
1986
Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
2001
Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.
1986
Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti–IGF-IR antibody
2005
Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.
1992