Standout Papers
Citation Impact
Citing Papers
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
2010 StandoutNobel
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
2015 Science
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
2013
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
2009 Science
Sporadic and hereditary amyotrophic lateral sclerosis (ALS)
2014
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
The TDP‐43 N‐terminal domain structure at high resolution
2016
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
2015
TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues
2018
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration
2018
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
2017
Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation
2019
Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders
2013
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils
2016
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain
2019 Standout
The role of FUS gene variants in neurodegenerative diseases
2014
Finishing the euchromatic sequence of the human genome
2004 StandoutNature
Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma
2012
“Structural characterization of the minimal segment of TDP-43 competent for aggregation”
2014
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor
2014
Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation
2016
A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis
2018 Nobel
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease
2007
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
2013
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
2010
Bacterial Meningitis: Pathogenesis, Pathophysiology, and Progress
1992
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains
2007
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity
2015
TDP43-Positive Intraneuronal Inclusions in a Patient with Motor Neuron Disease and Parkinson’s Disease
2010
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2008
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
2010
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
2016
FUS‐Immunoreactive Intranuclear Inclusions in Neurodegenerative Disease
2009
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism
2010
TDP-43 Proteinopathy in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2007
Spreading of pathology in neurodegenerative diseases: a focus on human studies
2015
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
2013
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation
2018
Pathogenic roles for Epstein–Barr virus (EBV) gene products in EBV-associated proliferative disorders
2002
Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies
2012
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
2015
Amyotrophic lateral sclerosis
2011 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
TAR-DNA Binding Protein 43 in Pick Disease
2008
Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis
2016
TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
2007
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
2016
Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology
2013
The Enigmatic Role of C9ORF72 in Autophagy
2017
TDP-43 NTD can be induced while CTD is significantly enhanced by ssDNA to undergo liquid-liquid phase separation
2018
Cognitive impairment in amyotrophic lateral sclerosis
2007
Autophagy: Renovation of Cells and Tissues
2011 Standout
Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion
2013
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
2013
A Novel CpG-free Vertebrate Insulator Silences the Testis-specific SP-10 Gene in Somatic Tissues
2007
Chapter 1 The Molecular Links Between TDP‐43 Dysfunction and Neurodegeneration
2009
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Decoding ALS: from genes to mechanism
2016 StandoutNature
Biomarkers in amyotrophic lateral sclerosis
2008
TDP-43 is a key player in the clinical features associated with Alzheimer’s disease
2014
ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
2016
Cancer/testis antigens: an expanding family of targets for cancer immunotherapy
2002
Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function
2013
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
2011 Standout
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
2010
Metazoan MicroRNAs
2018 Standout
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
The amyloidogenicity of a C-terminal region of TDP-43 implicated in Amyotrophic Lateral Sclerosis can be affected by anions, acetylation and homodimerization
2018
An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution
2014
RNA-binding proteins with prion-like domains in ALS and FTLD-U
2011
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene
2004
EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function
2001 StandoutNobel
Delineation of the Core Aggregation Sequences of TDP‐43 C‐Terminal Fragment
2011
Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
2008
Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics
2014
Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions
2007
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5
2007
Targeted Molecular Therapy of GBM
2003
Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
2013
Autophagy in Human Health and Disease
2013 Standout
Misregulated RNA processing in amyotrophic lateral sclerosis
2012
Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration
2009
Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
2011
TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy
2010
Malignant Gliomas in Adults
2008 Standout
TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
2009
Transactive Response DNA-Binding Protein 43 Burden in Familial Alzheimer Disease and Down Syndrome
2009
Amyotrophic lateral sclerosis—a model of corticofugal axonal spread
2013
Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core
2013
TDP-43 high throughput screening analyses in neurodegeneration: Advantages and pitfalls
2013
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
The epidemiology of ALS: a conspiracy of genes, environment and time
2013
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
2016
Emergence of vancomycin tolerance in Streptococcus pneumoniae
1999 StandoutNatureNobel
Alzheimer's Disease
2010 Standout
Limitations of stereotactic biopsy in the initial management ofgliomas
2001
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Basic mechanisms of neurodegeneration: a critical update
2010
The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43
2017
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
2005 Standout
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
TDP-43 gene analysis in frontotemporal lobar degeneration
2007
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
2009
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
2012
MicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis
2014
Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments
2009 Standout
Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
2014
Updated TDP-43 in Alzheimer’s disease staging scheme
2016
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS
2011
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
2009
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
2015
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
2011
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
2018
Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
2015 Standout
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
2011
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
2008
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response
2003
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
2015
Glia cells in amyotrophic lateral sclerosis: New clues to understanding an old disease?
2007
Exosome secretion is a key pathway for clearance of pathological TDP-43
2016
The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila
2012
Brain Tumors
2001 Standout
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
2010
TDP-43 skeins show properties of amyloid in a subset of ALS cases
2012
No association of TDP-43 with sporadic frontotemporal dementia
2007
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
2016 Standout
Sarcoplasmic redistribution of nuclear TDP‐43 in inclusion body myositis
2009
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Phase to Phase with TDP-43
2017
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Stress granules as crucibles of ALS pathogenesis
2013
Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas
1994
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Identification of Virus-Encoded MicroRNAs
2004 StandoutScience
ALS motor phenotype heterogeneity, focality, and spread
2009
Adoptive cell transfer as personalized immunotherapy for human cancer
2015 StandoutScience
Human CD8 + T Cell Responses to EBV EBNA1: HLA Class I Presentation of the (Gly-Ala)–Containing Protein Requires Exogenous Processing
1997
Review: Prion‐like mechanisms of transactive response DNA binding protein of 43 kDa (TDP ‐43) in amyotrophic lateral sclerosis (ALS )
2014
Different Patterns of Epstein-Barr Virus Latency in Endemic Burkitt Lymphoma (BL) Lead to Distinct Variants within the BL-Associated Gene Expression Signature
2012
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
2009
Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
2017
A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing
2018
Spermidine in health and disease
2018 StandoutScience
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
2011
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
The role of extracellular vesicles in neurodegenerative diseases
2016
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
2010
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
2012
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
2005
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
2013
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline
2010 StandoutNobel
Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations
2013
2016
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
2013 Science
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
2020
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
2009
Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models
2018
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Epstein-Barr Nuclear Antigen 1-Specific CD4+ Th1 Cells Kill Burkitt’s Lymphoma Cells
2002
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
2012
Works of W. Feiden being referenced
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas
2001
MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies
2002
Evidence of Focal Genetic Microheterogeneity in Glioblastoma Multiforme by Area-Specific CGH on Microdissected Tumor Cells
1999
Low values of 5‐hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors
2012
Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor
2001
Rat Monoclonal Antibodies Differentiating between the Epstein-Barr Virus Nuclear Antigens 2A (EBNA2A) and 2B (EBNA2B)
1995
Microvascular Changes during the Early Phase of Experimental Bacterial Meningitis
1990
Accuracy of stereotactic brain tumor biopsy: Comparison of the histologic findings in biopsy cylinders and resected tumor tissue
1991
Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease
1994
Expression of cancer testis genes in human brain tumors.
2000