Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.
1993
Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.
1993
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
Differential DNA sequence specificity and regulation of HIV-1 enhancer activity by cRel-RelA transcription factor.
1994
Direct and continuous assessment by cells of their position in a morphogen gradient
1995 StandoutNatureNobel
Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells
2009
The inducible transcription activator NF-κB: regulation by distinct protein subunits
1991
Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping
1995 StandoutScienceNobel
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Structure of the NF-κB p50 homodimer bound to DNA
1995 Nature
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
The AP-1 transcription factor Batf controls TH17 differentiation
2009 Nature
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1999 Standout
Regulation of yAP-1 nuclear localization in response to oxidative stress
1997
Recognition sequence of a highly conserved DNA binding protein RBP-Jx
1994
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions
2013 StandoutNature
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
1996 Standout
Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1
1994
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)
1992
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Malignant transformation by mutant Rel proteins
1991
Oxidative stress and gene regulation
2000
Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs
1990 Nature
Phosphorylation of p105 PEST Sequences via a Redox-insensitive Pathway Up-regulates Processing to p50 NF-κB
1996
Animal models of chronic obstructive pulmonary disease
2008
DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide
1991
Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system
1993 Nobel
Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo
2003 Nobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation
1993
The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function
1990
The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila
1991
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family
1992
Proteolytic degradation of MAD3 (IϰBα) and enhanced processing of the NF-ϰB precursor p105 are obligatory steps in the activation of NF-ϰB
1993
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
DNA binding by an amino acid residue in the C-terminal half of the Rel homology region
1994
Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62
1992
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc
1997 Nature
The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene
1992
Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity
1991
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Molecular genetics of Drosophila immunity
1994
Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase
1997
The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers
1993
Cooperation between oncogenes
1991
The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition
1992 Nature
Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65
1991 Nature
Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway
1991 Nature
Identification of Bach2 as a B-cell-specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
1998
Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors
1991 ScienceNobel
Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells
1997 Nobel
The immune response of Drosophila
2003 StandoutNatureNobel
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
1995 Standout
A structural taxonomy of DNA-binding domains
1991 Nature
The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism
1997
Oncogenes and signal transduction
1991 Standout
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal
1991
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB
1992 Nature
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit
1992
Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
1993
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
1992
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Dif, a dorsal-related gene that mediates an immune response in Drosophila
1993
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
The inhibitory ankyrin and activator Rel proteins
1992 Nobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
1994
A zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of transcription during early embryogenesis
1993
Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal
1990 Nobel
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
1993 Nature
Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product
1991
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity
1992 StandoutNobel
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 Standout
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
1993
Function and Activation of NF-kappaB in the Immune System
1994 Standout
Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting
1991
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
1993
Proteins controlling the nuclear uptake of NF-κB, Rel and dorsal
1991
Structure-based Prediction of bZIP Partnering Specificity
2005
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)
1995 StandoutNobel
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
1991
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
1992 StandoutNobel
E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways
1999
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
1995 Nobel
The Heme-Bach1 Pathway in the Regulation of Oxidative Stress Response and Erythroid Differentiation
2006
The precursor of NF-κB p50 has IκB-like functions
1992
Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.
1993
Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.
1991
Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells
1992
The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50.
1992 Nobel
The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner.
1993 Nobel
Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability
1996
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
1996
Casein Kinase II Phosphorylates IκBα at S-283, S-289, S-293, and T-291 and Is Required for Its Degradation
1996
The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.
1992
Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.
1994
Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
1991
Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity
1992
Cactus protein degradation mediates Drosophila dorsal-ventral signaling.
1995
Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB
1995
Inducible processing of interferon regulatory factor-2.
1992
Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.
1994
Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex
1991 Science
Comparison of the periplasmic receptors for L-arabinose, D-glucose/D-galactose, and D-ribose. Structural and Functional Similarity.
1991
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.
1993 Standout
Structure of NF-κB p50 homodimer bound to a κB site
1995 Nature
Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.
1994
The 65-kD subunit of NF-kappa B is a receptor for I kappa B and a modulator of DNA-binding specificity.
1990
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.
1994
PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila
1995 StandoutScienceNobel
Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid
1997
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.
1993
Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation
1995
NF-κB and Rel Proteins in Innate Immunity
1995
N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.
1993
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.
1992
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.
1991
The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.
1995
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
1995
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
1993
Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ
1996
Two Functionally Distinct Subsets of Mast Cells Discriminated By IL-2–Independent CD25 Activities
2014
Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo
1992
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.
1993 Nobel
In vivo control of NF-kappa B activation by I kappa B alpha.
1993
The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.
1991
The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
1993
The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.
1991
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice
1996
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.
1992
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
vRel is an inactive member of the Rel family of transcriptional activating proteins
1991
Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.
1993
cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos
1991 StandoutNobel
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
1991 Standout
Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.
1994
In vivo self-association of the Drosophila rel-protein dorsal.
1992
A Glycine-Rich Region in NF-κB p105 Functions as a Processing Signal for the Generation of the p50 Subunit
1996
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
Determination of the embryonic axes of Drosophila*
1991 StandoutNobel
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.
1995
NF-κB Subunit Regulation in Nontransformed CD4 + T Lymphocytes
1992 Science
Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.
1994
Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation
1991
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.
1991
Notch Signaling
1995 Science
Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB
1991 Science
Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region.
1994
Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger
1991
Related Target Enhancers for Dorsal and NF-κB Signaling Pathways
1994 Science
Autoregulation of I kappa B alpha activity.
1994
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.
1991
Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits.
1994
p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells
1992
Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.
1993
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.
1994
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.
1995
Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.
1994 StandoutNobel
A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.
1992
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain
1999 StandoutNobel
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
1993 Science
The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.
1992
Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative.
1992
Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes
1992 StandoutNobel
Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†
1996
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
1991
Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product
1996
In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB
1995
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
1993
Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs
1994
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells.
1993
c-rel activates but v-rel suppresses transcription from kappa B sites.
1991
Free Radicals in the Physiological Control of Cell Function
2002 Standout
REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN
1999
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Human T-Cell Leukemia Virus Type I Tax Activation of NF-ΝB/Rel Involves Phosphorylation and Degradation of IΙBκ and RelA (p65)-Mediated Induction of the italic toc-rel Gene
1994
Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.
1993
Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB
1996
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
1993
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
1993
The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.
1992 StandoutNobel
Works of Volker Blank being referenced
Lineage‐specific activators affect β‐globin locus chromatin in multipotent hematopoietic progenitors
2006
Characterization of the Hematopoietic Transcription Factor NF-E2 in Primary Murine Megakaryocytes
1998
HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells
2005
NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats
1992
The Maf transcription factors: regulators of differentiation
1997
Processing of the precursor of NF-κB by the HIV-1 protease during acute infection
1991 Nature
Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line
1991
Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus.
1991
Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus
2004
Human MafG Is a Functional Partner for p45 NF-E2 in Activating Globin Gene Expression
1997
The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
1990
Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.
1991
Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?
2007
Sequence of the mglB gene from Escherichia coli K12: Comparison of wild-type and mutant galactose chemoreceptors
1987