Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
2009 Science
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED
2015 StandoutNobel
Schizophrenia risk from complex variation of complement component 4
2016 StandoutNature
Peptidergic Cell-Specific Synaptotagmins inDrosophila: Localization to Dense-Core Granules and Regulation by the bHLH Protein DIMMED
2014
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Modeling psychiatric disorders for developing effective treatments
2015
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Neurotransmitters and neuromodulators in the basal ganglia
1990
Accurate classification of BRCA1 variants with saturation genome editing
2018 Nature
Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice
2009
Neuronal phosphoproteins
1987
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
2003
Imaging in the era of molecular oncology
2008 StandoutNature
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
2004 StandoutNature
Alternative splicing in individual aplysia neurons generates neuropeptide diversity
1987 StandoutNobel
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
1995 StandoutNature
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
2009 StandoutNature
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Cysteine cathepsins: From structure, function and regulation to new frontiers
2011
Extracellular matrix structure
2015 Standout
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
2004
A Cathepsin L Isoform that Is Devoid of a Signal Peptide Localizes to the Nucleus in S Phase and Processes the CDP/Cux Transcription Factor
2004
Exosome poly‐ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro‐atherothombotic cellular functions
2014
Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription
2002
Polyglutamine Pathogenesis
2002
The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system
2005
Use of Proteomics to Demonstrate a Hierarchical Oxidative Stress Response to Diesel Exhaust Particle Chemicals in a Macrophage Cell Line
2003
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
2006
70K heat shock related proteins stimulate protein translocation into microsomes
1988 StandoutNatureNobel
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Flow cytometry‐assisted purification and proteomic analysis of the corticotropes dense‐core secretory granules
2008
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
2008 Standout
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Sec61p and BiP directly facilitate polypeptide translocation into the ER
1992 StandoutNobel
Selective Neuronal Degeneration in Huntington's Disease
2006
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Toxic Potential of Materials at the Nanolevel
2006 StandoutScience
Structure of a yeast pheromone gene (MFα): A putative α-factor precursor contains four tandem copies of mature α-factor
1982
Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase
1983 StandoutNobel
Serpin Structure, Mechanism, and Function
2002 Standout
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Stress Hormones: Their Interaction and Regulation
1984 ScienceNobel
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast.
1983 StandoutNobel
Cell–matrix interactions: focus on proteoglycan–proteinase interplay and pharmacological targeting in cancer
2014
Evidence for Multifactor Regulation of the Adrenocorticotropin Secretory Response to Hemodynamic Stimuli*
1985
Structure-Based Design of Functional Amyloid Materials
2014 StandoutNobel
Cachectin alters anterior pituitary hormone release by a direct action in vitro.
1989 StandoutNobel
Soluble factors stimulating secretory protein translocation in bacteria and yeast can substitute for each other.
1987 StandoutNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Corticotropin-Releasing Activity of Monokines
1985 Science
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
1994
Expression cloning of a human corticotropin-releasing-factor receptor.
1993
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
2001
Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D
1994
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream.
1986 StandoutNobel
Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
1995 StandoutScience
Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
1992 StandoutScience
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1.
1991 StandoutNobel
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis
2005
Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor
1987 StandoutScience
Mediation by Corticotropin Releasing Factor (CRF) of Adenohypophysial Hormone Secretion
1986
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes.
1991 StandoutNobel
NEUROPEPTIDES: MULTIPLE MOLECULAR FORMS, METABOLIC PATHWAYS, AND RECEPTORS
1986
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor
1984 StandoutNobel
Autophagy in neurons: a review.
2002
Glycosylation and processing of prepro-α-factor through the yeast secretory pathway
1984 StandoutNobel
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
2002
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 Science
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Works of Vivian Hook being referenced
Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites
2008
Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression
2008
Identification of zymogen and mature forms of human carboxypeptidase H A processing enzyme for the synthesis of peptide hormones
1988
The Novel Role of Cathepsin L for Neuropeptide Production Illustrated by Research Strategies in Chemical Biology with Protease Gene Knockout and Expression
2011
Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity
2006
β‐Amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for β‐secretase activity in chromaffin vesicles
2002
Enrichment of Presenilin 1 Peptides in Neuronal Large Dense‐Core and Somatodendritic Clathrin‐Coated Vesicles
1998
Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons
2014
Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein
2008
Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing
1988
The Protein Architecture of Human Secretory Vesicles Reveals Differential Regulation of Signaling Molecule Secretion by Protein Kinases
2012
Purification and characterization of a cathepsin D protease from bovine chromaffin granules
1992
Protein Trafficking to Chromaffin Granules and Proteolytic Processing within Regulated Secretory Vesicles of Neuroendocrine Chromaffin Cells
2002
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
2004
Carboxypeptidase H-like immunoreactivity in the striatum of cats and monkeys
1988
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
2005
Proteomics of Neuroendocrine Secretory Vesicles Reveal Distinct Functional Systems for Biosynthesis and Exocytosis of Peptide Hormones and Neurotransmitters
2007
Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.
1982
Multireceptor-induced release of adrenocorticotropin from anterior pituitary tumor cells
1982 Nobel
Alternative pathways for production of β-amyloid peptides of Alzheimer's disease
2008
Proteases for Processing Proneuropeptides into Peptide Neurotransmitters and Hormones
2008
Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing.
1993
Detection of Proteolytic Activity by Fluorescent Zymogram In-Gel Assays
2000
A carboxypeptidase processing enzyme for enkephalin precursors
1982 Nature
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
2003
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
2005
Corticotropin releasing factor stimulates adrenocorticotropin and β-endorphin release from AtT-20 mouse pituitary tumor cells
1982 Nobel
Full‐Length and Truncated Alzheimer Amyloid Precursors in Chromaffin Granules: Solubilization of Membrane Amyloid Precursor Is Mediated by an Enzymatic Mechanism
1995
Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum
2001
Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain
2002
Possible nuclear protein kinase regulation of homologous ribonucleic acid polymerases from small dense nuclei of mouse brain during morphine tolerance-dependence
1981
(Met)enkephalin and carboxypeptidase processing enzyme are co-released from chromaffin cells by cholinergic stimulation
1985