Citation Impact
Citing Papers
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
2019
Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
2011
Structural Features for Functional Selectivity at Serotonin Receptors
2013 Science
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H 1 Receptor
2011
LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
2021
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
2019 Standout
Transcriptional data: a new gateway to drug repositioning?
2012
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
idTarget: a web server for identifying protein targets of small chemical molecules with robust scoring functions and a divide-and-conquer docking approach
2012
Possible Association Between 3,4-Methylenedioxymethamphetamine Abuse and Valvular Heart Disease
2007
Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses
2018 StandoutNobel
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist
2005
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
2016
Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ
2013 Standout
Deciphering Diseases and Biological Targets for Environmental Chemicals using Toxicogenomics Networks
2010
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets
2011
Receptor systems: Will mining the receptorome yield novel targets for pharmacotherapy?
2005
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Treatment of Parkinson's disease with pergolide and relation to restrictive valvular heart disease
2004
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
ChEMBL: a large-scale bioactivity database for drug discovery
2011 Standout
Selection of boron reagents for Suzuki–Miyaura coupling
2013 Standout
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
2015
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
2021
Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification
2010
Network medicine: a network-based approach to human disease
2010 Standout
Computational Methods in Drug Discovery
2014
Structure‐Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes
2015
On the Integration of In Silico Drug Design Methods for Drug Repurposing
2017
Structure-based drug screening for G-protein-coupled receptors
2012 StandoutNobel
Binding of Protein Kinase Inhibitors to Synapsin I Inferred from Pair-Wise Binding Site Similarity Measurements
2010
Synthesis and structure–activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor
2010
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain
2012
Drug repurposing: progress, challenges and recommendations
2018 Standout
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
2020 StandoutNobel
Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective
2016
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
SwissTargetPrediction: a web server for target prediction of bioactive small molecules
2014
DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome
2011
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Reverse Screening Methods to Search for the Protein Targets of Chemopreventive Compounds
2018
Systematic Drug Repositioning Based on Clinical Side-Effects
2011
Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization
2015
Ultra-large library docking for discovering new chemotypes
2019 Nature
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
2008
The neural basis of psychedelic action
2022 Standout
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
2010 Standout
Exploiting drug-disease relationships for computational drug repositioning
2011
Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome
2014
Emerging Topics in Structure-Based Virtual Screening
2013
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells
2003
Orthogonal photoswitching in a multifunctional molecular system
2016 StandoutNobel
Visible‐Light‐Driven Photoisomerization and Increased Rotation Speed of a Molecular Motor Acting as a Ligand in a Ruthenium(II) Complex
2015 StandoutNobel
The promises and perils of psychedelic pharmacology for psychiatry
2022
Optochemical Genetics
2011
Cardiac Intercellular Communication: Are Myocytes and Fibroblasts Fair-Weather Friends?
2012
Computational Drug Repositioning: From Data to Therapeutics
2013
Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets
2015
Leveraging big data to transform target selection and drug discovery
2015
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
2012 Standout
Mild Cobalt(III)‐Catalyzed C–H Hydroarylation of Conjugated C=C/C=O Bonds
2017
Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists
2016
A synthesis of 1-substituted 5-[2-(acylamino)ethyl]-1H-pyrazole-4-carboxamides
2009
Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
2011
Observations on Screening-Based Research and Some Concerning Trends in the Literature
2010
DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility
2014
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
Integrative methods for analyzing big data in precision medicine
2015
Ligand-Enabled γ-C(sp3)–H Olefination of Amines: En Route to Pyrrolidines
2016
Polymorphs and co-crystals of haloprogin: an antifungal agent
2014
Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety
2010 Standout
Modulatory profiling identifies mechanisms of small molecule-induced cell death
2011
Predicting New Indications for Approved Drugs Using a Proteochemometric Method
2012
Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS
2012
Correction: Binding of Protein Kinase Inhibitors to Synapsin I Inferred from Pair-Wise Binding Site Similarity Measurements
2010
Multiple Sclerosis
2018 Standout
Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
2012 Standout
Discovery of drug mode of action and drug repositioning from transcriptional responses
2010
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
2016 Standout
Updates on drug–target network; facilitating polypharmacology and data integration by growth of DrugBank database
2015
Extended-Connectivity Fingerprints
2010 Standout
Investigation of the Structure–Activity Relationships of Psilocybin Analogues
2020
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
2006 Standout
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors
2010
Origin of Cardiac Fibroblasts and the Role of Periostin
2009
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields
2014 Standout
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
An Aggregation Advisor for Ligand Discovery
2015
Head‐twitch response in rodents induced by the hallucinogen 2,5‐dimethoxy‐4‐iodoamphetamine: a comprehensive history, a re‐evaluation of mechanisms, and its utility as a model
2012
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Structure-Function of the G Protein–Coupled Receptor Superfamily
2012
Fibrosis — A Common Pathway to Organ Injury and Failure
2015 Standout
Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19
2020
Serotonin Receptors
2008
In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA)
2019
The Chemical Basis of Pharmacology
2010
A perspective on multi‐target drug discovery and design for complex diseases
2018
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Ligand and Decoy Sets for Docking to G Protein-Coupled Receptors
2011
Polypharmacology: Challenges and Opportunities in Drug Discovery
2014
The Halogen Bond
2016 Standout
Emerging Targets in Photopharmacology
2016 StandoutNobel
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles
2011 Standout
The scoring bias in reverse docking and the score normalization strategy to improve success rate of target fishing
2017
Efficient synthesis of indenes by FeCl3·6H2O-catalyzed intramolecular Friedel–Crafts reaction of aryl-substituted allylic alcohols
2009
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Optochemische Genetik
2011
The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
2020 Standout
Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4
2012
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins
2017 StandoutNobel
Works of Vincent Setola being referenced
Discovery of β-Arrestin–Biased Dopamine D 2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
2011
Identifying mechanism-of-action targets for drugs and probes
2012
Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)
2009
Chemical informatics and target identification in a zebrafish phenotypic screen
2011
Discovery of a Novel Member of the Histamine Receptor Family
2001
Predicting new molecular targets for known drugs
2009 Nature
Serotonin 5-HT2BReceptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT ReleaseIn VivoandIn Vitro
2008
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
2011
Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies
2005
Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment
2009
Binding of isotryptamines and indenes at h5-HT6 serotonin receptors
2005
1,2,3,4-Tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands
2004
Molecular Determinants for the Interaction of the Valvulopathic Anorexigen Norfenfluramine with the 5-HT2B Receptor
2005
Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo
2011
3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Interstitial Cells in Vitro
2003
Photochemical activation of TRPA1 channels in neurons and animals
2013
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands
2005
Serotonin and Angiotensin Receptors in Cardiac Fibroblasts Coregulate Adrenergic-Dependent Cardiac Hypertrophy
2008
5-ZATRYPTAMINE ANALOGS AS h5-HT6 SEROTONIN RECEPTOR LIGANDS
2005
Development, Validation, and Use of Quantitative Structure−Activity Relationship Models of 5-Hydroxytryptamine (2B) Receptor Ligands to Identify Novel Receptor Binders and Putative Valvulopathic Compounds among Common Drugs
2010
Design, Synthesis, and Validation of a β-Turn Mimetic Library Targeting Protein–Protein and Peptide–Receptor Interactions
2011
Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors
2009
Synthesis and receptor profiling ofStemonaalkaloid analogues reveal a potent class of sigma ligands
2011