Citation Impact
Citing Papers
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene.
1999
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
1999
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Regulation of p53 stability by Mdm2
1997 StandoutNature
p53 in growth control and neoplasia
1996
p53-Mdm2--the affair that never ends
2002
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein
2000
Alarmins: awaiting a clinical response
2012
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
2001
Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn
1997
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
1997 Standout
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
High mobility group protein-1 (HMG-1) is a unique activator of p53
1998
When Checkpoints Fail
1997 StandoutNobel
The ARF/p53 pathway
2000
Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments
2013
Hdmx Stabilizes Mdm2 and p53
2000
Chromatin and cell death
2003
Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein
1999
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
2000
The p53 pathway
1999
MDM2 — master regulator of the p53 tumor suppressor protein
2000
Analyzing real-time PCR data by the comparative CT method
2008 Standout
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway
2010
The biochemistry of apoptosis
2000 StandoutNature
MDM2 function
1998
A novelMDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer
2000
MDM2 interacts with MDMX through their RING finger domains
1999
p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation
1998
Proteasome inhibitors induce mitochondria‐independent apoptosis in human glioma cells
1999 StandoutNobel
DNA damage induces phosphorylation of the amino terminus of p53
1997
Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
2003
Cellular processing of platinum anticancer drugs
2005 Standout
The p53–Mdm2 module and the ubiquitin system
2002
Biochemical properties and biological effects of p53
1995
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
1998
Oncogene amplification in solid tumors
1999
The MDM2 gene amplification database
1998
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht
2000
Interaction between the retinoblastoma protein and the oncoprotein MDM2
1995 Nature
Proteases to die for
1998
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
1998
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1995 Nature
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Actin cleavage in various tumor cells is not a critical requirement for executing apoptosis
1998
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1995 Nature
p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
1999
Opposing Effects of Ras on p53
2000
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
2001 Standout
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
Exploring complex networks
2001 StandoutNature
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination
2002
Cloning and Characterization of RAD17, a Gene Controlling Cell Cycle Responses to DNA Damage in Saccharomyces Cerevisiae
1996
Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer
1996
The Roles of E6-AP and MDM2 in p53 Regulation in Human Papillomavirus-Positive Cervical Cancer Cells
2000
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2001 Standout
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
1996
A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein
1997
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Regulation of Mdm2-Directed Degradation by the C Terminus of p53
1998
p53-Mediated Regulation of Proliferating Cell Nuclear Antigen Expression in Cells Exposed to Ionizing Radiation
1999
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
Regulation of p53 Function
2001
The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
1996
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
1994
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
2005
mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein
1996
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
1996
MDM2 Suppresses p73 Function without Promoting p73 Degradation
1999 StandoutNobel
Mdm-2: “big brother” of p53
1997
Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene
1995
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
Quantitation of Viral Load Using Real-Time Amplification Techniques
2001
Surfing the p53 network
2000 StandoutNature
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Regulation of p53 stability
1999
Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation
2010 StandoutNobel
Activation of p53 in cervical carcinoma cells by small molecules
2000
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
1999
The Ubiquitin-Proteasome Pathway and Its Role in Cancer
2005
Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6
1998
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
1996
Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53
1998
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
The CDK7-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro
1997
Network of Dynamic Interactions between Histone H1 and High-Mobility-Group Proteins in Chromatin
2004
Caspases: Enemies Within
1998 StandoutScience
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.
1994
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
A simple physical model for binding energy hot spots in protein–protein complexes
2002 StandoutNobel
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1998
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
1998
Works of Vincent Maréchal being referenced
Mdm2: keeping p53 under control
1997
Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock
2011
Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis
1997
Stepwise Release of Biologically Active HMGB1 during HSV-2 Infection
2011
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis
1997
Quantitative Analysis of Human Herpesvirus 8 Viral Load Using a Real-Time PCR Assay
2000
Mapping of the p53 and mdm-2 Interaction Domains
1993
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.
1994
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.
1994
The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes
1994
Quantification of Enterovirus RNA in Sludge Samples Using Single Tube Real-Time RT-PCR
2000
Mapping of the p53 and mdm-2 interaction domains.
1993
Association of Chromatin Proteins High Mobility Group Box (HMGB) 1 and HMGB2 with Mitotic Chromosomes
2003