Standout Papers
Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
Reversal of the TCR Stop Signal by CTLA-4
2006 Science
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
2004
The ICOS/ICOSL Pathway Is Required for Optimal Antitumor Responses Mediated by Anti–CTLA-4 Therapy
2011
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
2012
Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity
2005
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
2009 StandoutNobel
Durable Adoptive Immunotherapy for Leukemia Produced by Manipulation of Multiple Regulatory Pathways of CD8+ T-Cell Tolerance
2012
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Anti–Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors
2009
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer
2007 StandoutNobel
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
2005 Standout
VISTA Regulates the Development of Protective Antitumor Immunity
2014
CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition
2010
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses
2001
Potent activity of soluble B7RP‐1‐Fc in therapy of murine tumors in syngeneic hosts
2002
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
The TIM gene family: emerging roles in immunity and disease
2003
The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
2001
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
2015 Standout
New regulatory co-receptors: inducible co-stimulator and PD-1
2002 StandoutNobel
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
2007
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
2003
The Cluster of BTN Genes in the Extended Major Histocompatibility Complex
2001
CTLA-4 regulates cell cycle progression during a primary immune response
2002
An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells
2004
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
2017 StandoutNobel
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
2003
The PD-1–PD-L pathway in immunological tolerance
2006 StandoutNobel
IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells
2005
A PD‐1 polymorphism is associated with disease progression in multiple sclerosis
2005
The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic Factors
2006
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
2005 StandoutNobel
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis
2006
Human prostate‐infiltrating CD8+ T lymphocytes are oligoclonal and PD‐1+
2009
Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family
2011
PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2
2002 StandoutNobel
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
2001
Telomeres shorten during ageing of human fibroblasts
1990 StandoutNatureNobel
Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis
2003
Structural mechanisms of costimulation
2002
Fine tuning the immune response through B7‐H3 and B7‐H4
2009
Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1
2004
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver
2005
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
2002 StandoutNobel
The immunological synapse for B-cell memory: the role of the ICOS and its ligand for the longevity of humoral immunity
2003
Inhibitory B7-family molecules in the tumour microenvironment
2008
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders
2005
PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
2004
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses
2003
Taking dendritic cells into medicine
2007 StandoutNatureNobel
The PD‐1 pathway in tolerance and autoimmunity
2010 Standout
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
2004
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
2004
The enemy within: keeping self-reactive T cells at bay in the periphery
2002
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
2010
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
2012
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
2002 Standout
Association of a putative regulatory polymorphism in the PD‐1 gene with susceptibility to type 1 diabetes
2003
Spinning molecular immunology into successful immunotherapy
2002
PD-1 and PD-1 ligands: from discovery to clinical application
2007
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
2003 StandoutNobel
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
2002 StandoutNature
B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation
2003
What's the difference between CD80 and CD86?
2003
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity
2003
Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis
2004
PD‐1 ligands expressed on myeloid‐derived APC in the CNS regulate T‐cell responses in EAE
2008
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
2013 StandoutNobel
The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function
2001
The B7–CD28 superfamily
2002
Paradoxical role of programmed death‐1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo
2004
Role of ICOS versus CD28 in antiviral immunity
2002
The right place at the right time: novel B7 family members regulate effector T cell responses
2002
Microanatomical localization of PD-1 in human tonsils
2002 StandoutNobel
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
PD‐1 signalling in CD4+ T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide‐induced tolerance
2010
PD-1: an inhibitory immunoreceptor involved in peripheral tolerance
2001
Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells
2005
Nucleotide sequence of the rightward operator of phage lambda.
1975 Standout
Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
2012 Standout
Studies on bacteriophage fd DNA
1977
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
2003
Phenotypic and Functional Analysis of Cd8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen
2001
Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2
2008
DNA sequence of a region of the φX174 genome coding for a ribosome binding site
1977 Nature
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver
2003 StandoutNobel
Enhancement of CD8+ T Cell Responses by ICOS/B7h Costimulation
2001
Nucleotide clusters in deoxyribonucleic acids. XI. Comparison of the sequences of the large pyrimidine oligonucleotides of bacteriophages S13 and φX174 deoxyribonucleic acids
1976
Use of DNA Polymerase I Primed by a Synthetic Oligonucleotide to Determine a Nucleotide Sequence in Phage f1 DNA
1973 StandoutNobel
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells
2004 StandoutNobel
A critical role for the programmed death ligand 1 in fetomaternal tolerance
2005
The lymphoproliferative defect in CTLA-4–deficient mice is ameliorated by an inhibitory NK cell receptor
2002 StandoutNobel
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy
2014 StandoutNobel
A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance to Toxoplasma gondii
2002
Cutting Edge: Inducible Costimulator Protein Regulates Both Th1 and Th2 Responses to Cutaneous Leishmaniasis
2002
Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells.
2002
DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping
1974
Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.
2003
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
2004
Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
2009
Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells
2002
Isolation and Sequence Analysis of a Ribosome-protected Fragment from Bacteriophage φX 174 DNA
1973
Expression of Programmed Death 1 Ligands by Murine T Cells and APC
2002
B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression
2004
DNA sequencing with chain-terminating inhibitors
1977 StandoutNobel
THE B7 FAMILY REVISITED
2005 Standout
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy
2014
B7H Costimulates Clonal Expansion of, and Cognate Destruction of Tumor Cells by, CD8+ T Lymphocytes In Vivo
2001
Inducible Costimulator Protein Controls the Protective T Cell Response Against Listeria monocytogenes
2002
Steps Toward Computer Analysis of Nucleotide Sequences
1980 StandoutScienceNobel
The Length of the Terminal Repetition in Adenovirus-2 DNA
1974 StandoutNobel
Staphylococcal Transfer Ribonucleic Acids
1974 StandoutNobel
Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction
2003 StandoutNobel
3′ Non-coding region sequences in eukaryotic messenger RNA
1976 StandoutNature
Staphylococcal Transfer Ribonucleic Acids
1974 StandoutNobel
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
2016 Standout
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function
2001
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
Ligand Binding Sites of Inducible Costimulator and High Avidity Mutants with Improved Function
2002
Constitutive Expression of the B7h Ligand for Inducible Costimulator on Naive B Cells Is Extinguished after Activation by Distinct B Cell Receptor and Interleukin 4 Receptor–mediated Pathways and Can Be Rescued by CD40 Signaling
2002
Programmed death-1 (PD-1)–deficient mice are extraordinarily sensitive to tuberculosis
2010
The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28
2004
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+T cells
2002
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
2000
The mechanism of replication of øX174 DNA
1975
DNA sequence at the C termini of the overlapping genes A and B in bacteriophage φX174
1977 StandoutNatureNobel
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
B7h is required for T cell activation, differentiation, and effector function
2003
Determination of a nucleotide sequence in bacteriophage f1 DNA by primed synthesis with DNA polymerase
1974 StandoutNobel
Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells
2003 StandoutNobel
PD-1 on dendritic cells impedes innate immunity against bacterial infection
2009
Impaired germinal center formation and recall T-cell–dependent immune responses in mice lacking the costimulatory ligand B7-H2
2003
The Use of Primed Synthesis by DNA Polymerase I to Study an Intercistronic Sequence of ΦX‐174 DNA
1975
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 StandoutNobel
Direct determination of DNA nucleotide sequences: Structure of a fragment of bacteriophage φX174 DNA
1974
The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses
2002
Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis
2006
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
2001
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Nucleotide sequence of the intercistronic region between genes G and F in bacteriophage X174DNA
1976
Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis
2003
IFN-α Directly Promotes Programmed Cell Death-1 Transcription and Limits the Duration of T Cell-Mediated Immunity
2011 StandoutNobel
Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production
2003
Direct determination of DNA nucleotide sequences. Structure of large specific fragments of bacteriophage φX174 DNA
1976
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer
2005
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses
2005
Inducible Costimulatory Molecule-B7-Related Protein 1 Interactions Are Important for the Clonal Expansion and B Cell Helper Functions of Naive, Th1, and Th2 T Cells
2003
Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells
2009
Characterization of Mouse and Human B7-H3 Genes
2002
Structure and function of telomeres
1991 StandoutNatureNobel
Immune Checkpoint Blockade in Cancer Therapy
2015 Standout
The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo
2011
Nucleotide sequence of bacteriophage G4 DNA
1978 StandoutNature
B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis
2002
PD-1 and Its Ligands in Tolerance and Immunity
2008 Standout
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
1985 StandoutNobel
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Programmed Death-1 Targeting Can Promote Allograft Survival
2002
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
2009
Disruption of the ICOS-B7RP-1 Costimulatory Pathway Leads to Enhanced Hepatic Immunopathology and Increased Gamma Interferon Production by CD4 T Cells in Murine Schistosomiasis
2003
Determination of the Nucleotide Sequence of a Fragment of Bacteriophage ϕX 174 DNA
1973
Nucleotide sequence of bacteriophage φX174 DNA
1977 StandoutNatureNobel
Works of Vincent Ling being referenced
Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor
2000
ICOS is critical for CD40-mediated antibody class switching
2001 Nature
The B7 family of immune-regulatory ligands.
2005
Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss
2003
Comparable in vivo efficacy of CD28/B7, ICOS/GL50, and ICOS/GL50B costimulatory pathways in murine tumor models: IFNγ-dependent enhancement of CTL priming, effector functions, and tumor specific memory CTL
2003
Assembly and Annotation of Human Chromosome 2q33 Sequence Containing the CD28, CTLA4, and ICOS Gene Cluster: Analysis by Computational, Comparative, and Microarray Approaches
2001
Partial digestion of 32P‐fd DNA with T4 endonuclease IV
1971
Pyrimidine Sequences from the DNA of Bacteriophages fd, fl, and ϕX174
1972
Inhibition of CTLA-4 Function by the Regulatory Subunit of Serine/Threonine Phosphatase 2A
2002
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
2000 StandoutNobel
CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression
2000
Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses
2003
The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation
2000
Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells
2000
Differential Expression of Inducible Costimulator-Ligand Splice Variants: Lymphoid Regulation of Mouse GL50-B and Human GL50 Molecules
2001
Surface Cytotoxic T Lymphocyte–associated Antigen 4 Partitions Within Lipid Rafts and Relocates to the Immunological Synapse under Conditions of Inhibition of T Cell Activation
2002
Fractionation and sequences of the large pyrimidine oligonucleotides from bacteriophage fd DNA
1972