Citation Impact
Citing Papers
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
PKB/AKT: functional insights from genetic models
2001
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
1998
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
CD43, a molecule with multiple functions
1999
Identification of serines‐1035/1037 in the kinase domain of the insulin receptor as protein kinase Cα mediated phosphorylation sites
1994
Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1
2004
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Characterization of a CD43/Leukosialin-mediated Pathway for Inducing Apoptosis in Human T-Lymphoblastoid Cells
1996
Jaks and Stats in signaling by the cytokine receptor superfamily
1995 Standout
Toll-like Receptors and Innate Immunity
2001
A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids
2003
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Animal models of chronic obstructive pulmonary disease
2008
Requirement of Phosphatidylinositol 3-Kinase Activity for Bradykinin Stimulation of NF-κB Activation in Cultured Human Epithelial Cells
1999
High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus
1989 Nature
Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways
1997
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism
1988
Insulin Resistance — Mechanisms, Syndromes, and Implications
1991
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
1999
Regulation of Ras-mediated signalling: more than one way to skin a cat
1995
Cellular survival: a play in three Akts
1999 Standout
Molecular Events Mediating T Cell Activation
1990
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
2009
Regulation of Insulin Action by Ceramide
2004
Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A
1999
The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB
1999
Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
2001
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo
1999
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Lipid signalling in disease
2008
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
1997
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
2017
Modulation of cellular apoptotic potential: contributions to oncogenesis
1999
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
IL-4 Function Can Be Transferred to the IL-2 Receptor by Tyrosine Containing Sequences Found in the IL-4 Receptor α Chain
1996
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
1999
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
1999
Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides
1999
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
The ST3Gal-I Sialyltransferase Controls CD8+ T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis
2000
Dissociation of Apoptosis from Proliferation, Protein Kinase B Activation, and BAD Phosphorylation in Interleukin-3-mediated Phosphoinositide 3-Kinase Signaling
1999
Protein kinase C: Mediator or inhibitor of insulin action?
1993
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
1998
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway
1998
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Cytokine receptor signalling
1995 Nature
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
1993
Ceramide Induces the Dephosphorylation and Inhibition of Constitutively Activated Akt in PTEN Negative U87MG Cells
2001
Cooperation of Src Homology Domains in the Regulated Binding of Phosphatidylinositol 3-Kinase
1995
The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway
2001
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors
1990
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation
2001
Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells
1994
Choline-linked Phosphoglycerides
1989
Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation
1994
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance
2016
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Structure, function, and biology of SHIP proteins
2000
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
1991
Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture
1989
Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt
1997
Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart
2000
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
A novel mechanism for acetylcholine to generate diacylglycerol in brain.
1990
Signaling through phosphatidylcholine breakdown.
1990
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
2010
Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.
1994
Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B
2002
Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.
1990
A general two-metal-ion mechanism for catalytic RNA.
1993 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.
1988
The Structure and Function of P55PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase
1995
Combinatorial patterns of somatic gene mutations in cancer
2008
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.
1996 StandoutNobel
The PI3K‒PDK1 connection: more than just a road to PKB
2000
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Hormonal stimulation of diacylglycerol formation in hepatocytes.
1989
Function of Ras as a molecular switch in signal transduction.
1992
Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils
1989
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
2000 StandoutNobel
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999
Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation
2003
CD43 is a ligand for E-selectin on CLA+ human T cells
2005
Regulation of Phospholipase D in HL-60 Granulocytes
1989
Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.
1990
Network of dendritic cells within the muscular layer of the mouse intestine
2005 StandoutNobel
Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells
1998
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*
1997 Standout
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Trk Receptors: Roles in Neuronal Signal Transduction
2003 Standout
Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons
1997
The regulation and cellular functions of phosphatidylcholine hydrolysis
1990
New Responsibilities for the PI3K Regulatory Subunit p85α
2001
How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.
1994
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme
1988
Common themes in microbial pathogenicity revisited
1997 Standout
Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.
1988
Effect of phorbol esters on protein kinase C-zeta.
1992
The β2-Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through Gi-Dependent Coupling to Phosphatidylinositol 3′-Kinase
2000
Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C
1987
Cutting Edge: CD43 Functions as a T Cell Counterreceptor for the Macrophage Adhesion Receptor Sialoadhesin (Siglec-1)
2001
P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells
1989
Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase
1998
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Activation of Protein Kinase C by Naturally Occurring Ether-linked Diglycerides
1989
Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.
1987
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Salmonella typhimuriuminduces an inositol phosphate flux in infected epithelial cells
1992
The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase
2000
1997 StandoutNobel
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
1997 Standout
Pseudomonas aeruginosa invasion of and multiplication within corneal epithelial cells in vitro
1995
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
1993 StandoutScience
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
14-3-3 Proteins: Structure, Function, and Regulation
2000 Standout
Cancer Genome Landscapes
2013 StandoutScience
Regulation of metabolism by the innate immune system
2015
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
2001
Interleukin 3-dependent survival by the Akt protein kinase
1997 Nobel
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.
1994
Engagement of distinct epitopes on CD 43 induces different co‐stimulatory pathways in human T cells
2016
Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.
1992
Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1
2000
Involvement of Protein Kinase C in Platelet-activating Factor-stimulated Diacylglycerol Accumulation in Murine Peritoneal Macrophages
1989
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Molecular Species Analysis of 1,2-Diglycerides Stimulated by α-Thrombin in Cultured Fibroblasts
1989
Analysis of Signal Transduction Pathways in Human Eosinophils Activated by Chemoattractants and the T-Helper 2–Derived Cytokines Interleukin-4 and Interleukin-5
1998
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Seeing the Machinery of Live Cells
1998 StandoutScienceNobel
Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
1999 Science
Analysis of Signal Transduction Pathways in Human Eosinophils Activated by Chemoattractants and the T-Helper 2–Derived Cytokines Interleukin-4 and Interleukin-5
1998
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Cytokine-Induced Protein Kinase B Activation and Bad Phosphorylation Do Not Correlate with Cell Survival of Hemopoietic Cells
1999
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
p110δ, a novel phosphoinositide 3-kinase in leukocytes
1997
The PI3K–PDK1 connection: more than just a road to PKB
2000
Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes
1989
SALMONELLOSIS: Host Immune Responses and Bacterial Virulence Determinants1
1996
Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis
1995
How BAD phosphorylation is good for survival
1999
Works of Vincent Duronio being referenced
Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells
2007
Acid sphingomyelinase in macrophage apoptosis
2004
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity
2007
The Effect of Protein Kinase-C Inhibition on Insulin Receptor Phosphorylation
1990
Ceramide‐1‐phosphate promotes cell survival through activation of the phosphatidylinositol 3‐kinase/protein kinase B pathway
2005
Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473
2002
Serine/threonine phosphorylation in cytokine signal transduction
2000
Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines
1996
Downstream Signalling Events Regulated by Phosphatidylinositol 3-Kinase Activity
1998
Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473
2000
Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase
1999
Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
1994
Effects of inhibitors of N-linked oligosaccharide processing on the biosynthesis and function of insulin and insulin-like growth factor-I receptors.
1988
Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity
1989
The B Cell Antigen Receptor Activates the Akt (Protein Kinase B)/Glycogen Synthase Kinase-3 Signaling Pathway Via Phosphatidylinositol 3-Kinase
1999
Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth.
1994
The Role of the SRC Homology 2-Containing Inositol 5′-Phosphatase in FcɛR1-Induced Signaling
1999
Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor
1995
Partial down‐regulation of protein kinase C reverses the growth inhibitory effect of phorbol esters on HepG2 cells
1990
p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.
1992
Characterization of the activation-associated isoform of CD43 on murine T lymphocytes.
1994
Acute effect of cigarette smoke on TNF-α release by macrophages mediated through the erk1/2 pathway
2006
Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation.
1994
Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells
1992
Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation
1998
Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members.
1992
Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.
1986