Standout Papers
- Thymic lymphomas in mice with a truncating mutation in Brca2. (1998)
- Involvement of Brca2 in DNA Repair (1998)
Citation Impact
Citing Papers
The human disease network
2007 Standout
Prospective identification of tumorigenic breast cancer cells
2003 Standout
Biallelic Inactivation of BRCA2 in Fanconi Anemia
2002 Science
BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure
2002 Science
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
In search of the tumour-suppressor functions of BRCA1 and BRCA2
2000 Nature
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks
2001
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
1999 StandoutNobel
Sensing and repairing DNA double-strand breaks
2002
Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells
1999
Chromosomal Rearrangements Occur in S. cerevisiae rfa1 Mutator Mutants Due to Mutagenic Lesions Processed by Double-Strand-Break Repair
1998
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
2001
Cell-cycle checkpoints and cancer
2004 StandoutNature
A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination
1998
Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes
2001
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans
2005 StandoutNobel
Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis
2000 Standout
Genetic instabilities in human cancers
1998 StandoutNature
Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
2009 StandoutNobel
Cellular Senescence in Cancer and Aging
2007 Standout
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line
1999
DNA repair pathways as targets for cancer therapy
2008
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin
2000
Chromosomal stability and the DNA double-stranded break connection
2001
A Genomic and Functional Inventory of Deubiquitinating Enzymes
2005 Standout
BRCA1, BRCA2, and DNA Damage Response: Collision or Collusion?
1998
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
2004 StandoutNobel
DNA Damage, Aging, and Cancer
2009 Standout
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer
2005
RAD51 is Involved in Repair of Damage Associated with DNA Replication in Mammalian Cells
2003
The Fanconi anaemia/BRCA pathway
2003
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Conditional mouse models of sporadic cancer
2002
Stochastic cancer progression driven by non‐clonal chromosome aberrations
2006
The Microprocessor complex mediates the genesis of microRNAs
2004 StandoutNature
Double-Strand Break Repair Deficiency and Radiation Sensitivity in BRCA2 Mutant Cancer Cells
1998
The emerging genetic and molecular basis of Fanconi anaemia
2001
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice
2003
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
2001
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage
2002
DNA double strand break repair and chromosomal translocation: Lessons from animal models
2001
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
2003
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair
2003
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Meiotic recombination in Caenorhabditis elegans
2007
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Regulation of chromatin structure by site-specific histone H3 methyltransferases
2000 StandoutNature
Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2
2006
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
2012 Standout
Chromosome Breaks and Genomic Instability
2000
Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer
2011
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
2002
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein
2001
Repair of DNA interstrand cross-links
2001
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
2009 Standout
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
2012 Standout
DNA double strand break repair in mammalian cells
2000
An Alternative Form of Replication Protein A Expressed in Normal Human Tissues Supports DNA Repair
2009 StandoutNobel
Tumour evolution inferred by single-cell sequencing
2011 StandoutNature
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
2013
Proteomics to study genes and genomes
2000 StandoutNature
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability
2006
Role for the Mammalian Swi5-Sfr1 Complex in DNA Strand Break Repair through Homologous Recombination
2010
Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions
2002
Skp’n with Cks1: Revelations from the Skp1-Skp2-Cks1-p27 Structure
2005
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition
2002
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
2001
BRCA2 Is Ubiquitinated In Vivo and Interacts with USP11, a Deubiquitinating Enzyme That Exhibits Prosurvival Function in the Cellular Response to DNA Damage
2004
Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia
2000 StandoutNobel
The transition state for formation of the peptide bond in the ribosome
2006 StandoutNobel
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
2005 StandoutScience
Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.
2001
Deletion of Ku86 causes early onset of senescence in mice
1999
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
1999 Science
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair
2008
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode .
2000
DNA Double-Strand Breaks
2002 StandoutNobel
Sporadic Epithelial Ovarian Cancer: Clinical Relevance of BRCA1 Inhibition in the DNA Damage and Repair Pathway
2008
Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
2008
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
2000 Nobel
Brca1 Controls Homology-Directed DNA Repair
1999
Human DNA Repair Genes
2001 StandoutScienceNobel
Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer Phenotypes
2010
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin
2008
Molecular views of recombination proteins and their control
2003
Works of Veronica Yu being referenced
A Kinase-Independent Function of Cks1 and Cdk1 in Regulation of Transcription
2005
The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome
2009
Involvement of Brca2 in DNA Repair
1998 StandoutNobel
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
2000
Thymic lymphomas in mice with a truncating mutation in Brca2.
1998 StandoutNobel