Standout Papers
Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
2003 StandoutScienceNobel
Neutralizing antibody response during acute and chronic hepatitis C virus infection
2004 StandoutNobel
T Cells with a CD4 + CD25 + Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8 + T Cells during Chronic Hepatitis C Virus Infection
2005
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
2003 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
2013 StandoutNobel
Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model.
1998
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
2011
Current progress in development of hepatitis C virus vaccines
2013
Five HLA-DP Molecules Frequently Expressed in the Worldwide Human Population Share a Common HLA Supertypic Binding Specificity
2010
Hepatitis C Virus and eliminating post-transfusion hepatitis
2000 StandoutNobel
Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C
1999
Hepatitis C Virus–Specific CD4+T Cell Response after Liver Transplantation Occurs Early, Is Multispecific, Compartmentalizes to the Liver, and Does Not Correlate with Recurrent Disease
2001 StandoutNobel
A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus
2006
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
2009 StandoutNature
Hepatitis C Virus Infection
2001 Standout
Immune responses to hepatitis C and non-hepatitis C antigens in hepatitis C virus infected and HIV-1 coinfected patients
2000
Interferon‐α Treatment Induces Delayed CD4 Proliferative Responses to the Hepatitis C Virus Nonstructural Protein 3 Regardless of the Outcome of Therapy
1997
Adaptive immune responses in acute and chronic hepatitis C virus infection
2005 Nature
Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection
2011
Humoral Immune Response in Acute Hepatitis C Virus Infection
2005
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
The influence of T cell cross-reactivity on HCV-peptide specific human T cell response
2006
Treatment of Acute Hepatitis C with Interferon Alfa-2b
2001
Discordant Role of CD4 T-Cell Response Relative to Neutralizing Antibody and CD8 T-Cell Responses in Acute Hepatitis C
2006
Interferon alfa treatment of HCV RNA carriers with persistently normal transaminase levels: A pilot randomized controlled study
1998
Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies
2007 StandoutNobel
Preferential loss of IL‐2–secreting CD4+ T helper cells in chronic HCV infection†
2005
The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
2004
Immunology of hepatitis B virus and hepatitis C virus infection
2005 Standout
Persistence of Viremia and the Importance of Long–Term Follow–Up After Acute Hepatitis C Infection
1999
Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization
2000 StandoutNobel
Extrahepatic manifestations of HCV infection: facts and controversies
1999
Vigorous Peripheral Blood Cytotoxic T Cell Response during the Acute Phase of Hepatitis C Virus Infection
2000
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
2006 StandoutNobel
PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection
2010
The role of immune responses in the pathogenesis of hepatitis C virus infection
1997
Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C
1998
T‐cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C†
2005
Hepatitis C: an update
2001
Immunopathogenesis of HCV Infection
1998
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
2003
Protective Immune Response to Hepatitis C Virus in Chimpanzees Rechallenged Following Clearance of Primary Infection
2001 StandoutNobel
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
2001 StandoutScience
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Intrahepatic CD8+ T-Cell Failure During Chronic Hepatitis C Virus Infection *
2005
Liver-Derived Hepatitis C Virus (HCV)-Specific CD4+ T Cells Recognize Multiple HCV Epitopes and Produce Interferon Gamma
2000 StandoutNobel
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
Detection of Type 2–Like T–Helper Cells in Hepatitis C Virus Infection: Implications for Hepatitis C Virus Chronicity
1997
Immune Responses to HCV and Other Hepatitis Viruses
2014
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
2009
Adaptive Immunity to the Hepatitis C Virus
2010
Hepatitis C virus–specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
2000
Detection of Functionally Altered Hepatitis C Virus–Specific Cd4+ T Cells in Acute and Chronic Hepatitis C
2003
Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence
1999
CD4 T Lymphocyte Proliferative Responses to Hepatitis C Virus (HCV) Antigens in Patients Coinfected with HCV and Human Immunodeficiency Virus Who Responded to Anti‐HCV Treatment
2002 StandoutNobel
Differential Cd4+ and Cd8+ T–Cell Responsiveness in Hepatitis C Virus Infection
2001
Priming of hepatitis C virus-specific cytotoxic t lymphocytes in mice following portal vein injection of a liver-specific plasmid DNA
2000 StandoutNobel
Characterization of Hcv–Specific Patr Class Ii Restricted Cd4+ T Cell Responses in An Acutely Infected Chimpanzee
2003
A self‐adjuvanting multiepitope immunogen that induces a broadly cross‐reactive antibody to hepatitis C virus†
2007
Analysis of a Successful Immune Response against Hepatitis C Virus
1999 StandoutNobel
Predicting HLA CD4 Immunogenicity in Human Populations
2018
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
2020 Standout
Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
1998
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Cancer immunotherapy comes of age
2011 StandoutNature
Hepatitis C Virus‐Specific Cytolytic T Lymphocyte and T Helper Cell Responses in Seronegative Persons
1997 StandoutNobel
Suppression of Hcv–Specific T Cells Without Differential Hierarchy Demonstrated Ex Vivo In Persistent Hcv Infection
2003
Effects of antiviral therapy on the cellular immune response in acute hepatitis C
2004
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C
2006
Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C
1999
Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection
2001
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
2005 Standout
Strategies and Prospects for Vaccination Against the Hepatitis C Viruses
2000 StandoutNobel
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
CD4 T Helper Type 1 and Regulatory T Cells Induced against the Same Epitopes on the Core Protein in Hepatitis C Virus–Infected Persons
2002
T cell responses in hepatitis C: the good, the bad and the unconventional
2011
Comparative features of hepatitis C virus infection in humans and chimpanzees
1997
Increased circulating and intrahepatic T‐cell‐specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy
2004
DNA-based vaccination against hepatitis C virus (HCV): effect of expressing different forms of HCV E2 protein and use of CpG-optimized vectors in mice
2002
Association of multispecific CD4+ response to hepatitis C and severity of recurrence after liver transplantation
1999 StandoutNobel
Immunity to hepatitis C virus: stunned but not defeated
2002
Genetic Immunization Generates Cellular and Humoral Immune Responses Against the Nonstructural Proteins of the Hepatitis C Virus in a Murine Model
1998
Genetic Heterogeneity of Hypervariable Region 1 of the Hepatitis C Virus (HCV) Genome and Sensitivity of HCV to Alpha Interferon Therapy
2000
The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity
2002
Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C
2005 StandoutNobel
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
Flying Under the Radar: The Immunobiology of Hepatitis C
2006 StandoutNobel
Broad Repertoire of the CD4+ Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes
2005
Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses
2003
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
2002
Memory T-Cell-Mediated Immune Responses Specific to an Alternative Core Protein in Hepatitis C Virus Infection
2004
Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen
2000
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection
2002 Standout
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Development of prophylactic and therapeutic vaccines against hepatitis C virus
2005
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Conserved Hierarchy of Helper T Cell Responses in a Chimpanzee during Primary and Secondary Hepatitis C Virus Infections
2004
Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia
1999
Control of Heterologous Hepatitis C Virus Infection in Chimpanzees Is Associated with the Quality of Vaccine-Induced Peripheral T-Helper Immune Response
2003
The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity
2004
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
2003
The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies
2000 Science
Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses
2006 StandoutNobel
Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection
1997 StandoutNobel
Broad Specificity of Virus-Specific CD4+T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection
2002
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
2001
Kinetics of CD4+and CD8+Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees
2003 StandoutNobel
Cationic microparticles are a potent delivery system for a HCV DNA vaccine
2004 StandoutNobel
Sustained Dysfunction of Antiviral CD8+T Lymphocytes after Infection with Hepatitis C Virus
2001
Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles
2002
Reduction of Retrovirus-Induced Immunosuppression by In Vivo Modulation of T Cells during Acute Infection
2004 StandoutNobel
Enhancement of Immunoglobulin G2a and Cytotoxic T-Lymphocyte Responses by a Booster Immunization with Recombinant Hepatitis C Virus E2 Protein in E2 DNA-Primed Mice
2000
Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy
1998 StandoutScience
Virus-Specific CD8+Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C
2002
Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees
2000
Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection
2002
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Cell-Mediated Immunity and the Outcome of Hepatitis C Virus Infection
2004
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
2000
Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance1 1The Bundesministerium für Bildung und Forschung and the European Union, as sponsors of the study, had no role in study design, data collection, analysis, or interpretation or in the writing and the decision to submit the report for publication.
2003
Hypervariable Region 1 Variants Act as TCR Antagonists for Hepatitis C Virus-Specific CD4+ T Cells
1999
Induction of Primary Human T Cell Responses against Hepatitis C Virus-Derived Antigens NS3 or Core by Autologous Dendritic Cells Expressing Hepatitis C Virus Antigens: Potential for Vaccine and Immunotherapy
2006
Characterization of Hepatitis C Virus Core-Specific Immune Responses Primed in Rhesus Macaques by a Nonclassical ISCOM Vaccine
2001 StandoutNobel
Works of V. Lamonaca being referenced
Conserved hepatitis C virus sequences are highly immunogenic for CD4+ T cells: Implications for vaccine development
1999
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
1996 StandoutNobel
Immunopathogenesis of hepatitis C virus infection
1999
Intrahepatic and circulating HLA class II-restricted, hepatitis C virus-specific T cells: Functional characterization in patients with chronic hepatitis C
2002
Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
2003
Antiviral Cell-Mediated Immune Responses During Hepatitis B and Hepatitis C Virus Infections
1998
Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients
1997 StandoutNobel