Standout Papers
Citation Impact
Citing Papers
DiarrheagenicEscherichia coli
1998 Standout
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
2016 Standout
New inhibitors of Helicobacter pylori urease holoenzyme selected from phage‐displayed peptide libraries
1999
Essential role of Helicobacter pyloriγ‐glutamyltranspeptidase for the colonization of the gastric mucosa of mice
1999
Role of Hpn and NixA of Helicobacter pylori in Susceptibility and Resistance to Bismuth and Other Metal Ions
1999
Staying alive overdosed: How does control urease activity?
2005
Helicobacter pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-like Receptor (TLR)-2-, TLR-4-, and Myeloid Differentiation Factor 88-independent Mechanism
2003
Identification of nonessential Helicobacter pylori genes using random mutagenesis and loop amplification
2001
Variability of gene order in different Helicobacter pylori strains contributes to genome diversity
1996
Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response
2004
Characterization of the roles of NikR, a nickel‐responsive pleiotropic autoregulator of Helicobacter pylori
2003
Lethality and centrality in protein networks
2001 StandoutNature
Unravelling the pathogenic role of Helicobacter pylori in peptic ulcer: Potential new therapies and vaccines
1994
Cloning and allelic exchange mutagenesis of two flagellin genes of Helicobacter felis
1999
Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5
2003
Structural Basis of Enhanced Binding of Extended and Helically Constrained Peptide Epitopes of the Broadly Neutralizing HIV-1 Antibody 4E10
2006
Characterisation of the urease-encoding gene complex of Yersinia enterocolitica
1994
Neutralization of HIV-1 primary isolate by ELDKWA-specific murine monoclonal antibodies
2005
Role of the thioredoxin system and the thiol-peroxidases Tpx and Bcp in mediating resistance to oxidative and nitrosative stress in Helicobacter pylori
2003
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
1998
Bacterial ureases in infectious diseases
2000
Oral multispecies biofilm development and the key role of cell–cell distance
2010 Standout
Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
2011 StandoutNobel
Cloning, expression and sequencing of Helicobacter felis urease genes
1993
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
2004 Standout
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
2009 StandoutNobel
The Physiology and Metabolism of the Human Gastric Pathogen Helicobacter pylori
1998
Multiple Oligomeric States of the Helicobacter pylori Vacuolating Toxin Demonstrated by Cryo-electron Microscopy
2002 StandoutNobel
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori
1995
Antibiotic resistance and its cost: is it possible to reverse resistance?
2010 Standout
Helicobacter pylori: microbiology of a ‘slow’ bacterial infection
1993
Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles
2008
Cloning and genetic characterization of a Hellcobacter pylori flagellin gene
1992
Survey of the year 2000 commercial optical biosensor literature
2001
Sequence of the Proteus mirabilis urease accessory gene ureG
1993
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
2006
Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
2008
Aflagellated mutants of Helicobacter pylori generated by genetic transformation of naturally competent strains using transposon shuttle mutagenesis
1993
Genetic analysis of the Helicobacter pylori vacuoiating cytotoxin: structural similarities with the IgA protease type of exported protein
1994
Interclade Neutralization and Enhancement of Human Immunodeficiency Virus Type 1 Identified by an Assay Using HeLa Cells Expressing Both CD4 Receptor and CXCR4/CCR5 Coreceptors
2004 StandoutNobel
The protein–protein interaction map of Helicobacter pylori
2001 Nature
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
2004 Standout
The primary transcriptome of the major human pathogen Helicobacter pylori
2010 StandoutNature
Responsiveness to acidity via metal ion regulators mediates virulence in the gastric pathogen Helicobacter pylori
2004
The Helicobacter pylori UreI protein: role in adaptation to acidity and identification of residues essential for its activity and for acid activation
2001
Alkali production by oral bacteria and protection against dental caries
2000
Helicobacter pylori: perspectives and time trends
2014
The thioredoxin antioxidant system
2013 Standout
Cell Lysis is Responsible for the Appearance of Extracellular Urease in Helicobacter pylori
2001
Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization
2017 StandoutNobel
Helicobacter pyloriInfection
2002 Standout
Survey of the year 2003 commercial optical biosensor literature
2004
Microbial hydrogenases: Primary structure, classification, signatures and phylogeny
1993
Genetic evidence for histidine kinase HP165 being an acid sensor of Helicobacter pylori
2004
A Riboswitch-Based Inducible Gene Expression System for Mycobacteria
2012 StandoutNobel
Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
2010 StandoutNobel
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
2008 Standout
Crystal structure of the nickel–iron hydrogenase from Desulfovibrio gigas
1995 StandoutNature
Prospects for the Development of a Vaccine Against Helicobacter pylori
1996
A predominant Th1 type of immune response is induced early during acute Helicobacter pylori infection in rhesus macaques
2000
The urea cycle of Helicobacter pylori
1996
Ordered cosmid library and high‐resolution physical—genetic map of Helicobacter pylori strain NCTC11638
1994
Recombination and clonal groupings within Helicobacter pylori from different geographical regions
1999
Induction of neutralizing antibody against human immunodeficiency virus type 1 (HIV-1) by immunization with gp41 membrane-proximal external region (MPER) fused with porcine endogenous retrovirus (PERV) p15E fragment
2005
Identification of the urease operon in Helicobacter pylori and its control by mRNA decay in response to pH
2000
Genotyping of Helicobacter pylori isolates by sequencing of PCR products and comparison with the RAPD technique
1996
Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant
2011 StandoutNobel
Bacterial ureases: structure, regulation of expression and role in pathogenesis
1993
Activation of Helicobacter pylori ureA promoter by a hybrid Escherichia coli–H. pylori rpoD gene in E. coli
1999
Site‐directed mutagenesis of Klebsiella aerogenes urease: Identification of histidine residues that appear to function in nickel ligation, substrate binding, and catalysis
1993
Effect of frequent consumption of a Lactobacillus casei‐containing milk drink in Helicobacter pylori‐colonized subjects
2003
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
Oral Immunization with Recombinant Helicobacter pylori Urease Induces Secretory IgA Antibodies and Protects Mice from Challenge with Helicobacter felis
1995
Helicobacter pylori nickel‐transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions
1995
Helicobacter pylori Urease.
1995
Regulation of transcription in Helicobacter pylori: simple systems or complex circuits?
2001
Purification and characterization of Klebsiella aerogenes UreE protein: A nickel‐binding protein that functions in urease metallocenter assembly
1993
Structural Analysis of the Epitope of the Anti-HIV Antibody 2F5 Sheds Light into Its Mechanism of Neutralization and HIV Fusion
2003
The AmiE aliphatic amidase and AmiF formamidase of Helicobacter pylori: natural evolution of two enzyme paralogues
2001
Identification and characterization of an aliphatic amidase in Helicobacter pylori
1997
Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state
2006
A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase
1997
The Helicobacter pylori UreI Protein Is Not Involved in Urease Activity but Is Essential for Bacterial Survival In Vivo
1998
Yersinia pestis , the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
1999 Standout
The crystal structure of urease from Klebsiella aerogenes
1995 StandoutScience
Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion
2000 StandoutScience
Rapid Loss of Motility of Helicobacter pylori in the Gastric Lumen In Vivo
2005
Helicobacter pylori rocF Is Required for Arginase Activity and Acid Protection In Vitro but Is Not Essential for Colonization of Mice or for Urease Activity
1999
Human Immunodeficiency Virus Type 1envClones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies
2005
Sensing and adapting to acid stress
2002
23S rRNA base pair 2057–2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G
2005 StandoutNobel
Cloning, sequencing, and expression of thermophilic Bacillus sp. strain TB-90 urease gene complex in Escherichia coli
1994
Construction of a Helicobacter pylori genome map and demonstration of diversity at the genome level
1992
Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope
2004
The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.
1995
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
2006
Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies
2004
Helicobacter pylori Urease Suppresses Bactericidal Activity of Peroxynitrite via Carbon Dioxide Production
2000
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
2013
Identification of the essential cysteine residue in Klebsiella aerogenes urease.
1991
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
2003 Standout
Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.
1993 Standout
Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity
1996
Cloning, Expression, and Catalytic Activity of Helicobacter hepaticus Urease
2001
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
1996 Standout
Protein Hpn: cloning and characterization of a histidine-rich metal-binding polypeptide in Helicobacter pylori and Helicobacter mustelae
1995
Acid Acclimation byHelicobacter pylori
2005
Nickel-Responsive Induction of Urease Expression in Helicobacter pylori Is Mediated at the Transcriptional Level
2001
Broadly Neutralizing Immune Responses against Hepatitis C Virus Induced by Vectored Measles Viruses and a Recombinant Envelope Protein Booster
2012 StandoutNobel
Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori
1994
Helicobacter species infection may be associated with cholangiocarcinoma: a meta-analysis
2013
Induction of Mucosal and Systemic Neutralizing Antibodies against Human Immunodeficiency Virus Type 1 (HIV-1) by Oral Immunization with Bovine Papillomavirus-HIV-1 gp41 Chimeric Virus-Like Particles
2004
Complex networks: Structure and dynamics
2006 Standout
Presence of Active Aliphatic Amidases in Helicobacter Species Able To Colonize the Stomach
2003
Immune Responses of Specific-Pathogen-Free Mice to Chronic Helicobacter pylori (Strain SS1) Infection
1998
Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa.
1992
GENETICS OF CAMPYLOBACTER AND HELICOBACTER
1992
Genetic evidence for histidine kinase HP165 being an acid sensor ofHelicobacter pylori
2004
Hydrogenases
2014 Standout
Pathogenicity of Helicobacter pylori: a perspective
1993
Purification and characterization of Mycoplasma penetrans Ca2+/Mg2+-dependent endonuclease
1997 StandoutNobel
Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli
1996 StandoutNobel
Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria
2012 Standout
Regulation of the inducible acetamidase gene of Mycobacterium smegmatis
1997
Motility of Helicobacter pylori Is Coordinately Regulated by the Transcriptional Activator FlgR, an NtrC Homolog
1999
Antibody Responses Elicited in Macaques Immunized with Human Immunodeficiency Virus Type 1 (HIV-1) SF162-Derived gp140 Envelope Immunogens: Comparison with Those Elicited during Homologous Simian/Human Immunodeficiency Virus SHIVSF162P4and Heterologous HIV-1 Infection
2006
Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin
1995
Pathogenesis ofHelicobacter pyloriInfection
2006 Standout
Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori
2003
Helicobacter pyloriPhysiology Predicted from Genomic Comparison of Two Strains
1999
A Single Injection of Recombinant Measles Virus Vaccines Expressing Human Immunodeficiency Virus (HIV) Type 1 Clade B Envelope Glycoproteins Induces Neutralizing Antibodies and Cellular Immune Responses to HIV
2003
Purification and characterization of Helicobacter mustelae urease
1991
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis
1996
Characterization of plasmid-borne afa-3 gene clusters encoding afimbrial adhesins expressed by Escherichia coli strains associated with intestinal or urinary tract infections
1993
Expression of the Helicobacter pylori ureI Gene Is Required for Acidic pH Activation of Cytoplasmic Urease
2000
Molecular biology of microbial ureases
1995 Standout
Role ofMycoplasma penetransEndonuclease P40 as a Potential Pathogenic Determinant
1999 StandoutNobel
Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori
1994
Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation
1997
Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1
2011 StandoutNobel
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
2013 Standout
Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production
1993
Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
1998 StandoutScience
Helicobacter pylori Glutamine Synthetase Lacks Features Associated with Transcriptional and Posttranslational Regulation
1998
Acid-Induced Activation of the Urease Promoters Is Mediated Directly by the ArsRS Two-Component System of Helicobacter pylori
2005
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Klebsiella aerogenes urease gene cluster: sequence of ureD and demonstration that four accessory genes (ureD, ureE, ureF, and ureG) are involved in nickel metallocenter biosynthesis
1992
Helicobacter pylori Virulence and Genetic Geography
1999 StandoutScience
A H + -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization
2000 Science
Metabolism and Genetics of Helicobacter pylori : the Genome Era
1999
cagA -Positive Helicobacter pylori Populations in China and The Netherlands Are Distinct
1998
Broad Neutralization of Human Immunodeficiency Virus Type 1 (HIV-1) Elicited from Human Rhinoviruses That Display the HIV-1 gp41 ELDKWA Epitope
2009
Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange
1993
Dependence of Helicobacter pylori Urease Activity on the Nickel-Sequestering Ability of the UreE Accessory Protein
2003
Characterization of an Acidic-pH-Inducible Stress Protein (hsp70), a Putative Sulfatide Binding Adhesin, fromHelicobacter pylori
1998
Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease
1995
pH-Regulated Gene Expression of the Gastric PathogenHelicobacter pylori
2003
Genetic Subtypes, Humoral Immunity, and Human Immunodeficiency Virus Type 1 Vaccine Development
2001
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori
2001
Structure-Function Analysis of the Epitope for 4E10, a Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody
2006
The Long Third Complementarity-Determining Region of the Heavy Chain Is Important in the Activity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5
2004
Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
2001
Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.
1994
Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes
2004
Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.
1995
Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications
2009
Elicitation of structure-specific antibodies by epitope scaffolds
2010 StandoutNobel
Nutritional requirements for growth of Helicobacter pylori
1994
Evidence for Specific Secretion Rather than Autolysis in the Release of Some Helicobacter pylori Proteins
1998
Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high‐affinity ferrous iron transporter
2000
Works of V Cussac being referenced
Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein
2000 StandoutNobel
Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity
1991
Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions
1992
Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange
1992