Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity
2006 StandoutScience
EglN2 associates with the NRF 1‐ PGC 1α complex and controls mitochondrial function in breast cancer
2015 StandoutNobel
Cytochrome P450 2B6: function, genetics, and clinical relevance
2012
Correlation of CYP2B6, CYP2C19, ABCC4 and SOD2 genotype with outcomes in allogeneic blood and marrow transplant patients
2011
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
2011 Nature
Anaesthesia, surgery, and challenges in postoperative recovery
2003 Standout
A Randomized Study of the Effects of Single-dose Gabapentin versus Placebo on Postoperative Pain and Morphine Consumption after Mastectomy
2002
The Analgesic Effect of Gabapentin and Mexiletine After Breast Surgery for Cancer
2002
Pharmacogenetics of Plasma Efavirenz Exposure after Treatment Discontinuation: An Adult AIDS Clinical Trials Group Study
2006
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
2007 StandoutNobel
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
2003
EULAR recommendations for the management of primary small and medium vessel vasculitis
2008 Standout
Genetic modulation of the pharmacological treatment of pain
2009
CYP2B6 genotype is a strong predictor of systemic exposure to efavirenz in HIV-infected Zimbabweans
2011
Lineage-Specific Changes in Biomarkers in Great Apes and Humans
2015 StandoutNobel
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part II
2010
Platelet pharmacogenomics
2010
Gender medicine and oncology: report and consensus of an ESMO workshop
2019
Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers
2007
Cytochrome P450 3A5 Genotype is Associated with Verapamil Response in Healthy Subjects
2007
P-glycoprotein: from genomics to mechanism
2003
Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity
2008
Clopidogrel with or without Omeprazole in Coronary Artery Disease
2010 Standout
Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment
2005
Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression
2003
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008 Standout
Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz
2005
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events
2006
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 Standout
Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide
2010
Computational redesign of enzymes for regio- and enantioselective hydroamination
2018
Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism
2004
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
CYP2D6 in the Metabolism of Opioids for Mild to Moderate Pain
2011
Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
2007
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites
2011
Balancing Acts
2004 Standout
Emergency Hospitalizations for Adverse Drug Events in Older Americans
2011 Standout
Integration of absorption, distribution, metabolism, and elimination genotyping data into a population pharmacokinetic analysis of nevirapine
2011
HLA-B*5701 Screening for Hypersensitivity to Abacavir
2008 Standout
Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2–CYP2B6.28, except CYP2B6.22)
2010
Effects of Moderate Alcohol Consumption on the Central Nervous System*
1998
Randomized Trial of Plasma Exchange or High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis
2007
Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects
1996
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)
2008
Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
2007
Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation
2010
The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals
2006
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Unusual Cytochrome P450 Enzymes and Reactions
2013
Sex and gender: modifiers of health, disease, and medicine
2020 Standout
Role of P-Glycoprotein in Pharmacokinetics
2003
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
MDR1 haplotypes significantly minimize intracellular uptake and transcellular P‐gp substrate transport in recombinant LLC‐PK1 cells
2006
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia
2008
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
2003
Crohn's disease
2016 Standout
CYP2B6 and OPRM1 gene variations predict methadone-related deaths
2010
Cytochrome P450 monooxygenases: perspectives for synthetic application
2006
Pharmacokinetic-Pharmacodynamic Crisis in the Elderly
2006
Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism
2012
Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs
2008
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
2008
Mass spectrometry‐based absolute quantification of microsomal cytochrome P450 2D6 in human liver
2009
The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity
2003
Multiple Novel Nonsynonymous CYP2B6 Gene Polymorphisms in Caucasians: Demonstration of Phenotypic Null Alleles
2004
Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation
1998
Interpatient variability in the pharmacokinetics of the HIV non‐nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism
2005
Morphine, Gabapentin, or Their Combination for Neuropathic Pain
2005
The effect of chronic renal failure on drug metabolism and transport
2008
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I
2010
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
2009
Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV-infected Individuals
2007
PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo
2012
Persistent postsurgical pain: risk factors and prevention
2006 Standout
Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges
2016 Standout
Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19
2001
Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
2011
Aberrant Splicing Caused by Single Nucleotide Polymorphism c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible for Decreased Expression and Activity of CYP2B6 in Liver
2008
Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation
2003
CYP2B6983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV/AIDS treatment
2007
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Metabolism of Efavirenz and 8-Hydroxyefavirenz by P450 2B6 Leads to Inactivation by Two Distinct Mechanisms
2006
Microtubules as a target for anticancer drugs
2004 Standout
Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the “Cocktail” Approach
2007
A Natural CYP2B6 TATA Box Polymorphism (–82T→ C) Leading to Enhanced Transcription and Relocation of the Transcriptional Start Site
2005
Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes
2004
Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis
2010 Standout
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS
2004
Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6
2003
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1
2003
Methadone inhibits CYP2D6 and UGT2B7/2B4in vivo: a study using codeine in methadone‐ and buprenorphine‐maintained subjects
2011
The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes
2002
Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study
2008
Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients
2007
Non-specific low back pain
2011 Standout
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver
2010
The Current State of Knowledge on Age, Sex, and Their Interactions on Clinical Pharmacology
2007
Evaluation of probe drugs and pharmacokinetic metrics for CYP2D6 phenotyping
2007
Herpes Zoster
2013 Standout
THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION
2005
Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine
2002
Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine
2004
Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation
2017 StandoutNobel
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
2016
Renal cell carcinoma
2017 Standout
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC
2009
Q172H Replacement Overcomes Effects on the Metabolism of Cyclophosphamide and Efavirenz Caused by CYP2B6 Variant with Arg262
2011
Pharmacogenetics of cyclophosphamide in patients with hematological malignancies
2005
The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z‐4‐hydroxy‐tamoxifen in human liver
2002
Stem cell-derived polarized hepatocytes
2020 StandoutNobel
HCV and the hepatic lipid pathway as a potential treatment target
2011
Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model
2016
Multicomponent reactions for the synthesis of pyrroles
2010 Standout
Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes
2004
The pharmacogenetics of antiretroviral therapy
2006
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
2003 Standout
Gender differences in drug responses
2006
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Pharmacogenomics of Human Liver Cytochrome P450 Oxidoreductase: Multifactorial Analysis and Impact on Microsomal Drug Oxidation
2009
Chronic Kidney Disease Diagnosis and Management
2019 Standout
2000
Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease
2016
Current evidence for a modulation of low back pain by human genetic variants
2009
Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel
2009
P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design
2005
Policy: NIH to balance sex in cell and animal studies
2014 StandoutNature
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Inferring statin-induced gene regulatory relationships in primary human hepatocytes
2011
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Cardiovascular Events as a Function of Serum Bilirubin Levels in a Large, Statin-Treated Cohort
2012
Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges
2018 Standout
Sex Is A Major Determinant of Cyp3a4 Expression in Human Liver
2003
Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
2000 StandoutScience
Differential expression and function of CYP2C isoforms in human intestine and liver
2003
The Analgesic Effect of Gabapentin and Mexiletine After Breast Surgery for Cancer
2002
Multidrug resistance in epilepsy: a pharmacogenomic update
2007
Allelic variations in CYP2B6 and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative hematopoietic stem cell transplantation
2010
On the mechanism of prostacyclin and thromboxane A2 biosynthesis
1989
Enzymatic asymmetric synthesis of chiral amino acids
2018
Cytochrome P450 3A4 and P‐glycoprotein Expression in Human Small Intestinal Enterocytes and Hepatocytes: A Comparative Analysis in Paired Tissue Specimens
2004
Cannabinoids for Medical Use
2015 Standout
Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning
2012
Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases
2017
Clinical impact of patient population differences and genomic variation in efavirenz therapy
2008
Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.
2004
Heme-Containing Oxygenases
1996 Standout
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Impact of CYP2B6 Polymorphism on Hepatic Efavirenz Metabolismin Vitro
2007
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Quantitative detection of codeine in human plasma using surface-enhanced Raman scattering via adaptation of the isotopic labelling principle
2017
Cytochrome P450 2B6 (CYP2B6) G516T influences nevirapine plasma concentrations in HIV‐infected patients in Uganda
2007
PolymorphicCYP2B6: Molecular Mechanisms and Emerging Clinical Significance
2007
Personalized Therapy in Pain Management: Where Do We Stand?
2010
Pharmacogenetics of Anti-HIV Drugs
2007
Works of Ute Hofmann being referenced
Chronopharmacology of intravenous and oral modified release verapamil
1999
Highly sensitive gas chromatographic–tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range
1999
Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
2010
Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein
2005
Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes
2016
6-Thioguanosine Diphosphate and Triphosphate Levels in Red Blood Cells and Response to Azathioprine Therapy in Crohn’s Disease
2005
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
2000
Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: Comparison of sparteine and dextromethorphan*
1996
Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake
1996
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists
2015
Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography–mass spectrometry
2000
Determination of propafenone and its phase I and phase II metabolites in plasma and urine by high-performance liquid chromatography–electrospray ionization mass spectrometry
2000
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*
1996
Reconstitution of β-carotene hydroxylase activity of thermostable CYP175A1 monooxygenase
2005
A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes
2009
MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine
2002
UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo
2009
Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study
2006
Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: Evidence from clinical and pharmacokinetic data
2005
Determination of 6-Thioguanosine Diphosphate and Triphosphate and Nucleoside Diphosphate Kinase Activity in Erythrocytes: Novel Targets for Thiopurine Therapy?
2010
Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK–PD modelling analysis
2001
Disposition and first-pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender?*
1996
Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry
1990
Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
2011
Influence of Age and Cytochrome P450 2C9 Genotype on the Steady-State Disposition of Diclofenac and Celecoxib
2003
Identification of metabolic fluxes in hepatic cells from transient 13C‐labeling experiments: Part II. Flux estimation
2007
Increased??Absorption??of??Digoxin from??the??Human??Jejunum Due??to??Inhibition??of??Intestinal Transporter-Mediated Efflux
2007
Dihydrocodeine: A new opioid substrate for the polymorphic CYP2D6 in humans*
1995
Rapid, highly sensitive method for the determination of morphine and its metabolites in body fluids by liquid chromatography–mass spectrometry
1999
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.
2001
Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*
1997
Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency
2002
Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry
1995
Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing
1999
Converting Aspartase into a β‐Amino Acid Lyase by Cluster Screening
2014
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers
2000
Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group
2008
Synthesis of novel prostaglandin F2α isomers and structure of an enzymatically formed 13-hydroxyprostaglandin endoperoxide
1987
Evidence for morphine-independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites
2006