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Citing Papers
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
2003
Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation
2001
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
A role for the RNA pol II–associated PAF complex in AID-induced immune diversification
2012
MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
2005
Cutting Edge: Hypermutation in Ig V Genes from Mice Deficient in the MLH1 Mismatch Repair Protein
1999
Hallmarks of Cancer: The Next Generation
2011 Standout
Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
2000
Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice
1985 Nature
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
2004
From molecular to modular cell biology
1999 StandoutNatureNobel
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Immunity through DNA deamination
2003
Mutations occur in the Ig S region but rarely in S regions prior to class switch recombination
2003
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
2002
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
2010
Positive and negative selection events during B lymphopoiesis
1995
Emerging links between hypermutation of antibody genes and DNA polymerases
2001
Hypermutation in antibody affinity maturation
1999
AID and mismatch repair in antibody diversification
2002
RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA Mutators
2002
Multiple sequences from downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain
1998
Two levels of protection for the B cell genome during somatic hypermutation
2008 Nature
The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes
1996
IgH Class Switch Recombination to IgG1 in DNA-PKcs-Deficient B Cells
2002
The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination
2012 StandoutNobel
Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands
1998
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
2003 Nature
Mechanisms of chromosomal translocations in B cell lymphomas
2001
Induction of Somatic Mutation in a Human B Cell Line In Vitro
1997
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways
1989
Role of AID in Tumorigenesis
2007 StandoutNobel
PMS2-deficiency diminishes hypermutation of a λ1 transgene in young but not older mice
1999
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Transcription-induced Cleavage of Immunoglobulin Switch Regions by Nucleotide Excision Repair Nucleases in Vitro
2000
Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells
2011
1p36: Every subband a suppressor?
1995
Somatic hypermutation of VκJκ rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs
1999
Reshaping human antibodies for therapy
1988 StandoutNatureNobel
Palindromic but not G-rich sequences are targets of class switch recombination
2001
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
2003 Nature
Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process
1998
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
2001 Nature
Transcription, topoisomerases and recombination
1994
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
2003
The regulation of somatic hypermutation
2004
Probing Immunoglobulin Gene Hypermutation with Microsatellites Suggests a Nonreplicative Short Patch DNA Synthesis Process
1998
Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes
2000 Nature
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
2010
Towards an understanding of somatic hypermutation
2001
Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development
1996
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
2003
BCR Ligation Induces Receptor Editing in IgM+IgD− Bone Marrow B Cells In Vitro
1997
A coming-of-age story: activation-induced cytidine deaminase turns 10
2009
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
2006 StandoutNobel
Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting
1998
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice
2004
Membrane‐bound IgM obstructs B cell development in transgenic mice
1989
Clonal selection and learning in the antibody system
1996 StandoutNature
Genome System Architecture and Natural Genetic Engineering in Evolution
1999
Mechanism and control of class-switch recombination
2002
Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription
1998
AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations
2009
I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
2008
Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
1999
The PU.1 and NF-EM5 binding motifs in the Igκ 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vκ gene
2001
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
1991 StandoutNatureNobel
C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion
2003
Somatic immunoglobulin hypermutation
2002
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc
2004
Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas
2003
Amino acid insertions and deletions contribute to diversify the human Ig repertoire
1998
The occurrence and significance of V gene mutations in B cell—Derived human malignancy
2001
Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection
1998
Somatic hypermutagenesis in immunoglobulin genes
1992
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes
2003
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
2000
Differential expression of activation‐induced cytidine deaminase (AID) in nodular lymphocyte‐predominant and classical Hodgkin lymphoma
2005
Induction of Somatic Hypermutation Is Associated with Modifications in Immunoglobulin Variable Region Chromatin
2003
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice
1997
Sequences related to immunoglobulin kappa chain messenger RNA in T cells.
1976 StandoutNobel
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment
1987
Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells
1981 Nature
Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.
1983 StandoutNobel
Mammalian DNA Mismatch Repair
1999
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.
1994 Nobel
Receptor editing in self-reactive bone marrow B cells.
1993
Somatic generation of antibody diversity.
1976 StandoutNobel
Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ
1987 Science
Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.
1987
Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus
1982 Nobel
Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.
1990
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes
1999
Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2
2003
An appraisal of the application of recombinant DNA techniques to chromosome defects
1985
Organization of Immunoglobulin Genes: Reiteration Frequency of the Mouse κ Chain Constant Region Gene
1974 StandoutNobel
Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines
1982 Nobel
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity
1983 Science
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
2001 Nobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
1983 StandoutNobel
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
1985 Nature
Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles.
1991
A hyperconversion mechanism generates the chicken light chain preimmune repertoire
1987
Both DNA strands of antibody genes are hypermutation targets
1998 Nobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
1998
Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice
1998
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
1988
Mouse Immunoglobulin Genes: Studies on the Reiteration Frequency of Light‐Chain Genes by Hybridisation Procedures
1975 StandoutNobel
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest
1997
Epigenetic Reprogramming in Mammalian Development
2001 StandoutScience
Expression of the AID protein in normal and neoplastic B cells
2004
Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.
1991 Nobel
Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.
1993
Somatic hypermutation of the AID transgene in B and non-B cells
2002
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.
1978
Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins.
1981
A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments
1980
Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constant region of kappa chain in the mouse
1974 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes
1983
Deletions in immunoglobulin mu chains.
1982 StandoutNobel
Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment
1999 StandoutNobel
Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia
2000
The connection between transcription and genomic instability
2002
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
1980 StandoutNatureNobel
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences
1984 StandoutNatureNobel
Mismatch Repair Co-opted by Hypermutation
1998 Science
Analysis of somatic mutations in kappa transgenes.
1990
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes
1984 StandoutNatureNobel
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.
1984
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma
1980 Nature
Cis‐acting sequences that affect somatic hypermutation of Ig genes
1998
The T lymphocyte antigen receptor—paradigm lost
1982 Nature
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.
1986
Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.
1982
Allelic exclusion in transgenic mice carrying mutant human IgM genes.
1988
SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES
1996
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.
1982
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
1981
Reward versus Risk: DNA Cytidine Deaminases Triggering Immunity and Disease
2005
An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development
1982
Somatic hypermutation of an immunoglobulin mu heavy chain transgene.
1993
The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region
2003
H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
2003
Position-dependent inhibition of class-switch recombination by PGK-neorcassettes inserted into the immunoglobulin heavy chain constant region locus
1999
Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes
1998
Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line
1985 NatureNobel
The Transcriptional Promoter Regulates Hypermutation of the Antibody Heavy Chain Locus
1997
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement.
1985
Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction
2000
Antibody Diversity
1978 Science
Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells
2002
Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.
1980
Recombined flanks of the variable and joining segments of immunoglobulin genes.
1982
AID Mediates Hypermutation by Deaminating Single Stranded DNA
2003
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
1984
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line
2001
Extrachromosomal DNA transformation of Caenorhabditis elegans.
1985
Untranslated immunoglobulin kappa light chain mRNA in a lambda light chain-producing mouse myeloma, MOPC104E.
1980 StandoutNobel
Unusual association of V, J and C regions in a mouse immunoglobulin λ chain
1982 Nature
Transcription of mouse kappa chain genes: implications for allelic exclusion.
1980 StandoutNobel
BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
1998
Extrachromosomal DNA Transformation of Caenorhabditis elegans
1985
Quantitative Regulation of Class Switch Recombination by Switch Region Transcription
2001 StandoutNobel
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas.
2004
Immunoglobulin Gene Rearrangement in Immature B Cells
1980 StandoutScienceNobel
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene.
1981
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.
1984 StandoutNobel
Genome-wide somatic hypermutation
2004
Somatic hypermutation of the B cell receptor genesB29(Igβ, CD79b) andmb1(Igα, CD79a)
2003
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
1999
Development of the Primary Antibody Repertoire
1987 Science
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
1983
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
2003
Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
1998
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.
1983 StandoutNobel
A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes
1985 Nobel
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
1979 StandoutNatureNobel
Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.
1993 StandoutNobel
Somatic hypermutation of an immunoglobulin transgene in K transgenic mice
1987 Nature
Human lymphocyte Hybridomas and Monoclonal Antibodies
1986
DNA Breaks in Hypermutating Immunoglobulin Genes: Evidence for a Break-and-Repair Pathway of Somatic Hypermutation
2001
Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia
2000
Reiteration frequency of immunoglobulin light chain genes: further evidence for somatic generation of antibody diversity.
1976 StandoutNobel
Restricted association of V and J-C gene segments for mouse lambda chains.
1984 StandoutNobel
A novel type of aberrant recombination in immunoglobulin genes and its implications for V–J joining mechanism
1983 Nature
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells
2003 StandoutNobel
Immunoglobulin Somatic Hypermutation
2007
Rat kappa-chain J-segment genes: Two recent gene duplications separate rat and mouse
1982
Inducible DNA breaks in Ig S regions are dependent on AID and UNG
2005
AID to overcome the limitations of genomic information
2005 StandoutNobel
Works of Ursula Storb being referenced
Somatic Hypermutation and Class Switch Recombination in Msh6−/−Ung−/− Double-Knockout Mice
2006
Immunoglobulin transgenes as targets for somatic hypermutation
1998
Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney
2007
The E Box Motif CAGGTG Enhances Somatic Hypermutation without Enhancing Transcription
2003
The 3′ Igκ enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic κ gene expression
2001
Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation
1996
Immunoglobulin Genes: Generating Diversity with AID and UNG
2002
γ2b transgenic mice as a model for the role of immunoglobulins in B cell development
1994
AID in somatic hypermutation and class switch recombination
2006
A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci
1991
The contested role of uracil DNA glycosylase in immunoglobulin gene diversification
2005
Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes
2002
Expression of Immunoglobulin Genes in Transgenic Mice and Transfected Cellsa
1988
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes
1997
Progress in understanding the mechanism and consequences of somatic hypermutation
1998
Targeting of AID to Immunoglobulin Genes
2007
The molecular basis of somatic hypermutation of immunoglobulin genes
1996
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
2004
Attracting AID to targets of somatic hypermutation
2010
The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription
2009
Pre-B cells in κ-transgenic mice
1985 Nature
Influence of CpG Methylation and Target Spacing on V(D)J Recombination in a Transgenic Substrate
1993
Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice
1984 Nature
Structural alterations in J regions of mouse immunoglobulin λ genes are associated with differential gene expression
1982 Nature
Evidence for multiple immunoglobulin genes
1974
The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes
1998
Mapping of immunoglobulin variable region genes: relationship to the ‘deletion’ model of immunoglobulin gene rearrangement
1981
The mechanism of somatic hypermutation studied with transgenic and transfected target genes
1996
Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains
1980
Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice
1983 Nature
Expression, Allelic Exclusion and Somatic Mutation of Mouse Immunoglobulin Kappa Genes
1986
The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions
2005
Somatic mutation of immunoglobulin light-chain variable-region genes
1981
The switch region associated with immunoglobulin Cμ genes is DNase I hypersensitive in T lymphocytes
1981 Nature
Somatic Hypermutation of an Artificial Test Substrate Within an Igκ Transgene
1998
Immunoglobulin .mu.- and .gamma.-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice
1981
Quantitation of Immunoglobulin Genes by Nucleic Acid Hybridization with RNA from Myeloma and Spleen Microsomes
1972
A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript
1998
High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytes
1984 Nature
Somatic hypermutation of immunoglobulin and non–immunoglobulin genes
2001
Physical Linkage of Mouse λ Genes by Pulsed-Field Gel Electrophoresis Suggests that the Rearrangement Process Favors Proximate Target Sequences
1989
Immunoglobulin gene ‘remnant’ DNA - implications for antibody gene recombination
1984
Sequences of immunoglobulin λ1 genes in a λ1 defective mouse strain
1982 Nature
RNA sequences homologous to the 3' portion of immunoglobulin .alpha.-chain mRNA in thymus-derived lymphocytes
1979
B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes
1997
Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for “allelic exclusion”
1980
Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells
1977
Direct demonstration of immunoglobulin κ chain RNA in thymus T cells by in situ hybridization
1978
Different Mismatch Repair Deficiencies All Have the Same Effects on Somatic Hypermutation
1999
Nucleosome Stability Dramatically Impacts the Targeting of Somatic Hypermutation
2012
Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene
1981
Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes
1998 Science
Rearrangement of immunoglobulin genes
1979
A Novel Cytidine Deaminase Affects Antibody Diversity
2000
Rearranged and germline immunoglobulin .kappa. genes: different states of DNase I sensitivity of C.kappa. genes in immunocompetent and nonimmune cells
1981