Standout Papers
Citation Impact
Citing Papers
Doc2b Is a High-Affinity Ca 2+ Sensor for Spontaneous Neurotransmitter Release
2010 Science
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
2002
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Binding to Rab3A-interacting Molecule RIM Regulates the Presynaptic Recruitment of Munc13-1 and ubMunc13-2
2006
A comparison between exocytic control mechanisms in adrenal chromaffin cells and a glutamatergic synapse
2006 Nobel
Rab3-interacting Molecule γ Isoforms Lacking the Rab3-binding Domain Induce Long Lasting Currents but Block Neurotransmitter Vesicle Anchoring in Voltage-dependent P/Q-type Ca2+ Channels
2010
Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
2000
Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)
2003
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
2007
Plasmalemmal Phosphatidylinositol-4,5-Bisphosphate Level Regulates the Releasable Vesicle Pool Size in Chromaffin Cells
2005 Nobel
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
2010 StandoutNobel
Two components of transmitter release from the chick ciliary presynaptic terminal and their regulation by protein kinase C
1999
UNC-13 is required for synaptic vesicle fusion in C. elegans
1999
Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
2006 StandoutNobel
A post-docking role for active zone protein Rim
2001
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin
2001
Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1
2006 StandoutNobel
The molecular machinery of synaptic vesicle exocytosis
2003
Vesicle trafficking: pleasure and pain from SM genes
2003
Molecular determinants of presynaptic active zones
2000
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release
2006
The presynaptic cytomatrix of brain synapses
2001
Multiple Roles for the Active Zone Protein RIM1α in Late Stages of Neurotransmitter Release
2004 StandoutNobel
Distinct domains of complexin I differentially regulate neurotransmitter release
2007
Identification of the Minimal Protein Domain Required for Priming Activity of Munc13-1
2005
Molecular mechanisms of active zone function
2003
Functional and physical coupling of voltage‐sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism
2001
Regulated exocytosis and SNARE function (Review)
2003
Regulation of transmitter release by Unc-13 and its homologues
2000
Amisyn, a Novel Syntaxin-binding Protein That May Regulate SNARE Complex Assembly
2002
C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function
2004 StandoutNobel
Heterogeneous Presynaptic Release Probabilities: Functional Relevance for Short-Term Plasticity
2003 Nobel
Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins☆☆Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF548738 and AF548739.
2003 StandoutNobel
Munc18-1 Promotes Large Dense-Core Vesicle Docking
2001 StandoutNobel
Re‐evaluation of phorbol ester‐induced potentiation of transmitter release from mossy fibre terminals of the mouse hippocampus
2000
SNARE regulators: matchmakers and matchbreakers
2003
RIM1: an edge for presynaptic plasticity
2002
Multi-protein assemblies underlie the mesoscale organization of the plasma membrane
2014 StandoutNobel
Vesicle Docking in Regulated Exocytosis
2008
An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
2001 Nature
RIM1α and RIM1β Are Synthesized from Distinct Promoters of theRIM1Gene to Mediate Differential But Overlapping Synaptic Functions
2008 StandoutNobel
UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains
2006
Mutation Associated with an Autosomal Dominant Cone-Rod Dystrophy CORD7 Modifies RIM1-Mediated Modulation of Voltage-Dependent Ca2+Channels
2007
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
Doc2 Supports Spontaneous Synaptic Transmission by a Ca2+-Independent Mechanism
2011
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
1999 Nature
Drosophila Unc-13 is essential for synaptic transmission
1999
Snares and munc18 in synaptic vesicle fusion
2002 StandoutNobel
Alternative splicing in the first α‐helical region of the Rab‐binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?
2004
Redundant Localization Mechanisms of RIM and ELKS inCaenorhabditis elegans
2005
Inhibition of SNARE Complex Assembly Differentially Affects Kinetic Components of Exocytosis
1999 Nobel
Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch
2006 StandoutNobel
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
2004 StandoutNobel
ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses
2009 StandoutNobel
The Presynaptic Active Zone
2012 StandoutNobel
Structure and function of SNARE and SNARE-interacting proteins
2005
Calcium sensors in regulated exocytosis
1998
Pushing synaptic vesicles over the RIM
2011
The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors
2011
The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release
2007 Nobel
Calmodulin and Munc13 Form a Ca2+ Sensor/Effector Complex that Controls Short-Term Synaptic Plasticity
2004
Regulation of the Readily Releasable Vesicle Pool by Protein Kinase C
1998
Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
2006
Delineation of the Oligomerization, AP-2 Binding, and Synprint Binding Region of the C2B Domain of Synaptotagmin
1998
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Assembling the Presynaptic Active Zone
2001
Dissection of Three Ca 2+ -Dependent Steps Leading to Secretion in Chromaffin Cells from Mouse Adrenal Slices
2000
Rim1 and Rabphilin-3 Bind Rab3-GTP by Composite Determinants Partially Related through N-terminal α-Helix Motifs
2001
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes
2009
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
2005 StandoutNobel
Energetics and dynamics of SNAREpin folding across lipid bilayers
2007 StandoutNobel
Synaptic vesicle fusion
2008
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
The Probability of Quantal Secretion Near a Single Calcium Channel of an Active Zone
2000
Synaptotagmin I functions as a calcium regulator of release probability
2001 StandoutNatureNobel
Membrane Fusion
2003 StandoutNobel
Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties
2004 StandoutNobel
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
The C2 domains of synaptotagmin – partners in exocytosis
2004
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
SAD: A Presynaptic Kinase Associated with Synaptic Vesicles and the Active Zone Cytomatrix that Regulates Neurotransmitter Release
2006
β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs
2002 StandoutNobel
Goα and Diacylglycerol Kinase Negatively Regulate the Gqα Pathway in C. elegans
1999
Mechanisms of membrane fusion: disparate players and common principles
2008
Munc13-1 Is Required for Presynaptic Long-Term Potentiation
2011
The calyx of Held
2006
Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis
2004
Molecular organization of the presynaptic active zone
2006
Regulation of Membrane Fusion in Synaptic Excitation-Secretion Coupling: Speed and Accuracy Matter
2007
Diversification of synaptic strength: presynaptic elements
2002
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
2011
Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
A minimal domain responsible for Munc13 activity
2005
RIM proteins and their role in synapse function
2010
Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses
2003 StandoutNobel
Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons
2000 Nature
Interactions of Presynaptic Ca2+ Channels and Snare Proteins in Neurotransmitter Release
1999
Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
2003 Nobel
v-SNARE Actions during Ca2+-Triggered Exocytosis
2007
Munc18-1 in secretion: lonely Munc joins SNARE team and takes control
2007
The Activation of Exocytotic Sites by the Formation of Phosphatidylinositol 4,5-Bisphosphate Microdomains at Syntaxin Clusters
2005
SNARE-mediated membrane fusion
2001
RIM Binding Proteins (RBPs) Couple Rab3-Interacting Molecules (RIMs) to Voltage-Gated Ca2+ Channels
2002
Synaptotagmin I, a Ca2+ sensor for neurotransmitter release
2003
Solution Structure of the RIM1α PDZ Domain in Complex with an ELKS1b C-terminal Peptide
2005 StandoutNobel
RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
2011 StandoutNobel
Calcium Channel Regulation and Presynaptic Plasticity
2008
RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13
2011 StandoutNobel
Protein kinase C potentiates transmitter release from the chick ciliary presynaptic terminal by increasing the exocytotic fusion probability
1999
RIM1α is required for presynaptic long-term potentiation
2002 StandoutNatureNobel
Single Molecule Observation of Liposome-Bilayer Fusion Thermally Induced by Soluble N-Ethyl Maleimide Sensitive-Factor Attachment Protein Receptors (SNAREs)
2004 Nobel
The Voltage-Gated Ca2+ Channel Is the Ca2+ Sensor of Fast Neurotransmitter Release
2001
Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7)☆
2003
Syntaxin 1A Interacts with Multiple Exocytic Proteins to Regulate Neurotransmitter Release In Vivo
1999
Serotonin Inhibition of Synaptic Transmission
1999
Synaptotagmin Regulation of Coated Pit Assembly
2000 StandoutNobel
SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release
2007
v‐SNAREs control exocytosis of vesicles from priming to fusion
2005 StandoutNobel
Rim, a Component of the Presynaptic Active Zone and Modulator of Exocytosis, Binds 14-3-3 through Its N Terminus
2003
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25
2000
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Molecular mechanisms of neurotransmitter release
2001
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
2002 StandoutNatureNobel
Differential Control of Vesicle Priming and Short-Term Plasticity by Munc13 Isoforms
2002
Vesicle Pools and Ca2+ Microdomains: New Tools for Understanding Their Roles in Neurotransmitter Release
1998 Nobel
Cast
2002
Quantitative Relationship between Transmitter Release and Calcium Current at the Calyx of Held Synapse
2001 Nobel
THE SYNAPTIC VESICLE CYCLE
2004 StandoutNobel
Single-Molecule Studies of the Neuronal SNARE Fusion Machinery
2009 Nobel
Aberrant Morphology and Residual Transmitter Release at the Munc13-Deficient Mouse Neuromuscular Synapse
2005
Regulation of Releasable Vesicle Pool Sizes by Protein Kinase A-Dependent Phosphorylation of SNAP-25
2004 Nobel
Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca2+
2003 StandoutNobel
Protein Kinase C-Dependent Phosphorylation of Synaptosome-Associated Protein of 25 kDa at Ser187Potentiates Vesicle Recruitment
2002 Nobel
Principles of Exocytosis and Membrane Fusion
2004
Structure and Regulation of Voltage-Gated Ca2+ Channels
2000 Standout
Cycling of Synaptic Vesicles: How Far? How Fast!
2001
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion
2010 StandoutNobel
A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila.
2000
Imaging single membrane fusion events mediated by SNARE proteins
2004 StandoutNobel
SNARE-catalyzed Fusion Events Are Regulated by Syntaxin1A–Lipid Interactions
2007
RIM function in short- and long-term synaptic plasticity
2005 StandoutNobel
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
2002 StandoutNobel
Phorbol Esters Potentiate Evoked and Spontaneous Release by Different Presynaptic Mechanisms
2000
Crystal Structure of the RIM2 C2A-Domain at 1.4 Å Resolution,
2005 StandoutNobel
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
2010
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters
2002
ELKS, a Protein Structurally Related to the Active Zone-associated Protein CAST, Is Expressed in Pancreatic β Cells and Functions in Insulin Exocytosis: Interaction of ELKS with Exocytotic Machinery Analyzed by Total Internal Reflection Fluorescence Microscopy
2005
Interactions between proteins implicated in exocytosis and voltage–gated calcium channels
1999
A Temperature-Sensitive Paralytic Mutant Defines a Primary Synaptic Calcium Channel inDrosophila
2000
Emerging Roles of Presynaptic Proteins in Ca ++ -Triggered Exocytosis
2002 ScienceNobel
A highly Ca 2+ -sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells
2002
CAPS-1 and CAPS-2 Are Essential Synaptic Vesicle Priming Proteins
2007
Rabphilin Knock-Out Mice Reveal That Rabphilin Is Not Required for Rab3 Function in Regulating Neurotransmitter Release
1999 StandoutNobel
TheCaenorhabditis elegans unc-64Locus Encodes a Syntaxin That Interacts Genetically with Synaptobrevin
1998
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
Protein Kinase C Increases the Apparent Affinity of the Release Machinery to Ca2+ by Enhancing the Release Machinery Downstream of the Ca2+ Sensor
2001
Presynaptic Mechanism for Phorbol Ester-Induced Synaptic Potentiation
1999
The C2b Domain of Synaptotagmin Is a Ca2+–Sensing Module Essential for Exocytosis
2000
cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala
2008
RIM genes differentially contribute to organizing presynaptic release sites
2012 StandoutNobel
Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release
2008
Syntaxin Modulation of Calcium Channels in Cortical Synaptosomes As Revealed by Botulinum Toxin C1
2000
PRESYNAPTIC RECEPTORS
1998
Differential expression of two novel Munc13 proteins in rat brain
1999
Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses
1999 Nobel
Pharmacology of the receptors for the phorbol ester tumor promoters
2000
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site
2011
Sensitization of regulated exocytosis by protein kinase C
2002
Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
2004
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles
2004
Regulation of the UNC-18–Caenorhabditis elegansSyntaxin Complex by UNC-13
1999
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Different Effects on Fast Exocytosis Induced by Synaptotagmin 1 and 2 Isoforms and Abundance But Not by Phosphorylation
2006 StandoutNobel
SNARE Protein Structure and Function
2003
Complexin II plays a positive role in Ca 2+ -triggered exocytosis by facilitating vesicle priming
2008
RIM function in short- and long-term synaptic plasticity
2005 StandoutNobel
The Cerebellum-Specific Munc13 Isoform Munc13-3 Regulates Cerebellar Synaptic Transmission and Motor Learning in Mice
2001 StandoutNobel
Works of Uri Ashery being referenced
Super-resolution Imaging Reveals the Internal Architecture of Nano-sized Syntaxin Clusters
2012
An efficient method for infection of adrenal chromaffin cells using the Semliki Forest virus gene express1on system
1999
Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells
2006
DOC2B Acts as a Calcium Switch and Enhances Vesicle Fusion
2008
Multiple functional domains are involved in tomosyn regulation of exocytosis
2007
Receptor-mediated Regulation of Tomosyn-Syntaxin 1A Interactions in Bovine Adrenal Chromaffin Cells
2007
Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release
1998 StandoutNobel
Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex
2001
Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming
2001
Phospholipase D1 Production of Phosphatidic Acid at the Plasma Membrane Promotes Exocytosis of Large Dense-core Granules at a Late Stage
2007
Evaluation of the Heterogeneous Reactivity of the Syntaxin Molecules on the Inner Leaflet of the Plasma Membrane
2009
DOC2A and DOC2B are sensors for neuronal activity with unique calcium‐dependent and kinetic properties
2006
The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis
2002 Nobel
A presynaptic role for the ADP ribosylation factor (ARF)-specific GDP/GTP exchange factor msec7-1
1999
Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells
2000 Nobel
Membrane depolarization combined with release of calcium from internal stores does not trigger secretion from PC 12 cells.
1993
Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis
2010
Alteration of Ca2+Dependence of Neurotransmitter Release by Disruption of Ca2+Channel/Syntaxin Interaction
1997 Nobel
Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner
2004