Standout Papers

Persisting oncogenic herpesvirus induced by the tumour promoter TPA 1978 2026 1994 2010 1.2k
  1. Persisting oncogenic herpesvirus induced by the tumour promoter TPA (1978)
    Harald zur Hausen, Frank J. O’Neill et al. Nature
  2. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells (1985)
    Elisabeth Schwarz, U.K. Freese et al. Nature

Citation Impact

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The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
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Evidence of Prevalent Genital-Type Human Papillomavirus Infections in Adults and Children
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1988
Activation of the epstein‐barr virus genome by 5‐aza‐cytidine in latently infected human lymphoid lines
1981
Tumour promoter TPA enhances transformation of human leukocytes by Epstein–Barr virus
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Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes
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HLA-A11 Epitope Loss Isolates of Epstein-Barr Virus From a Highly A11 + Population
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Human papillomavirus type 16 DNA sequence
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Synchronous and sequential activation of latently infected Epstein-Barr virus genomes
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Differential regulation of papilloma virus early gene expression in transformed fibroblasts and carcinoma cell lines.
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The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.
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Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.
1994
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
1991
Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.
1990
Clustered repeat sequences in the genome of Epstein Barr virus
1983
Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.
1989
Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1
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1987
Human papillomavirus type 18 DNA is integrated at a single chromosome site in cervical carcinoma cell line SW756
1987
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Analysis of integrated human papillomavirus type 16 DNA in cervical cancers: amplification of viral sequences together with cellular flanking sequences
1990
Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells
1987
Cross‐linking of cell surface immunoglobulins induces epstein‐barr virus in burkitt lymphoma lines
1984
The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones.
1987
Differential inducibility of Epstein‐Barr virus in cloned, non‐producer raji cells
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A keratinocyte-specific transcription factor, KRF-1, interacts with AP-1 to activate expression of human papillomavirus type 18 in squamous epithelial cells.
1991
Amplification of the integrated viral transforming genes of human papillomavirus 18 and its 5'-flanking cellular sequence located near the myc protooncogene in HeLa cells.
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Organization of the Epstein-Barr virus DNA molecule. III. Location of the P3HR-1 deletion junction and characterization of the NotI repeat units that form part of the template for an abundant 12-O-tetradecanoylphorbol-13-acetate-induced mRNA transcript
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The structure of the termini of the DNA of Epstein-Barr virus
1979
The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
1991
Identification of a transforming gene of human papillomavirus type 16
1989
DNA-binding-defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivate with altered specificities.
1994
Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae
1996
Cell Cycle Control and Cancer
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Transcriptional differences of the human papillomavirus type 16 genome between precancerous lesions and invasive carcinomas
1988
A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator
1987
Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180
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Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.
1987
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
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1987
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1987
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1994
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1989
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1988
The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1.
1994
Suppression in vivo of human papillomavirus type 18 E6-E7 gene expression in nontumorigenic HeLa X fibroblast hybrid cells
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1985
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1982
Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18
1988
The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element
1990
Transient replication of human papillomavirus DNAs
1992
Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine.
1988 StandoutNobel
Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.
1992
Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7
1989
Activation of latent Epstein–Barr virus by antibody to human IgM
1978 Nature
Early primary infection and high Epstein‐barr virus antibody titers in greenland eskimos at high risk for nasopharyngeal carcinoma
1984
Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral transactivators and a phorbol ester
1989
Epstein-Barr virus RNA. VIII. Viral RNA in permissively infected B95-8 cells
1982
Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.
1987
Role of the human papillomaviruses in human cancer.
1991
Organization of repeated regions within the Epstein-Barr virus DNA molecule
1980
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
1989 Standout
Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
1985
Is the Epstein-Barr Virus Involved in Hodgkin's Disease?
1989
Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency
1987
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma
1982 StandoutNobel
Interplay of viral and cellular proteins along the long control region of human papillomavirus type 18
1988
Numerous nuclear proteins bind the long control region of human papillomavirus type 16: a subset of 6 of 23 DNase I-protected segments coincides with the location of the cell-type-specific enhancer
1989
The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes
1989
Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs
1980
The Role of Viruses in Human Tumors
1980 StandoutNobel
A viral-cellular junction fragment from a human papillomavirus type 16-positive tumor is competent in transformation of NIH 3T3 cells
1988
Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.
1986
Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.
1986
Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells
1988
Viruses in Human Cancers
1991 StandoutScienceNobel
Tumor initiators and promoters in the induction of Epstein—Barr virus
1979 StandoutNobel
Increased sensitivity of human keratinocytes immortalized by human papillomavirus type 16 DNA to growth control by retinoids.
1992
Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrate
1979
Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation
1995
A novel type of human papillomavirus associated with genital neoplasias
1986 Nature
Sequence duplication and internal deletion in the integrated human papillomavirus type 16 genome cloned from a cervical carcinoma
1988
Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters
1990
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression
1986
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Negative regulation of the BZLF1 promoter of Epstein-Barr virus
1991
Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome
1987
Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.
1992 StandoutNobel
The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells
1987
DNA sequence and genome organization of genital human papillomavirus type 6b.
1983 StandoutNobel
Characterization of murine polyclonal antisera and monoclonal antibodies generated against intact and denatured human papillomavirus type 1 virions
1991 StandoutNobel
Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells.
1987
INTRACELLULAR SURVEILLANCE OF PERSISTING VIRAL INFECTIONS
1986
Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells.
1991 StandoutNobel
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
1984 StandoutNature
Characterization of primary human keratinocytes transformed by human papillomavirus type 18
1988
Antibodies to HPV-16 E6 and E7 proteins as markers for HPV-16-associated invasive cervical cancer
1992
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Homologous upstream sequences near Epstein-Barr virus promoters.
1983
E5 Protein of Human Papillomavirus Type 16 Protects Human Foreskin Keratinocytes from UV B-Irradiation-Induced Apoptosis
2002
Structure of defective DNA molecules in Epstein-Barr virus preparations from P3HR-1 cells
1984 StandoutNobel
Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18
1990
Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.
1987
A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
1983 StandoutNobel
Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells
1986
Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain
1992
Multiplicity‐dependent biological and biochemical properties of epstein‐barr virus (EBV) rescued from non‐producer lines after superinfection with P3HR‐1 EBV
1980 StandoutNobel
Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.
1983 StandoutNobel
Major EB virus-specific cytoplasmic transcripts in a cellular clone of the HR-1 burkitt lymphoma line during latency and after induction of viral replicative cycle by phorbol esters
1983
Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells
1989
Identification of polypeptide components of the Epstein-Barr virus early antigen complex with monoclonal antibodies
1983
Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes
1992
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
1990 StandoutScience
Retinoic acid inhibition of Epstein-Barr virus induction
1979 StandoutNatureNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
1982 Nature
Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens
1987
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.
1992 StandoutNobel
The EB virus genome in Daudi Burkitt's lymphoma cells has a deletion similar to that observed in a non-transforming strain (P3HR-1) of the virus.
1984
Characterization of a cell type-specific enhancer found in the human papilloma virus type 18 genome.
1987
The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product
1989 StandoutScience
Latent and lytic cycle promoters of Epstein-Barr virus.
1983
The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein
1987
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element
1986 StandoutNobel
Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA
1987
Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells
1988
Cloning of monomeric human papillomavirus type 16 DNA integrated within cell DNA from a cervical carcinoma
1986
Nonradioactive RNA in situ hybridization detection of human papillomavirus 16-E7 transcripts in squamous cell carcinomas of the uterine cervix using confocal laser scan microscopy.
1991
Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers
1988

Works of U.K. Freese being referenced

Two distant clusters of partially homologous small repeats of Epstein-Barr virus are transcribed upon induction of an abortive or lytic cycle of the virus
1983
Geographical prevalence of two types of Epstein-Barr virus
1986
Persisting oncogenic herpesvirus induced by the tumour promoter TPA
1978 StandoutNatureNobel
Molecular cloning and partial nucleotide sequence of human papillomavirus type 1a DNA
1982
Two distant regions of the Epstein-Barr virus genome with sequence homologies have the same orientation and involve small tandem repeats.
1982
A putative transforming gene of jijoye virus differs from that of Epstein-Barr virus prototypes
1985
A complete set of overlapping cosmid clones of M-ABA virus derived from nasopharyngeal carcinoma and its similarity to other Epstein-Barr virus isolates
1984
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
1985 StandoutNatureNobel
c-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations.
1984
Papilloma virus-induced tumors contain a virus-specific transcript
1982
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