Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Three-dimensional structure of rabbit liver [Cd7]metallothionein-2a in aqueous solution determined by nuclear magnetic resonance
1988 StandoutNobel
gp340 Expressed on Human Genital Epithelia Binds HIV-1 Envelope Protein and Facilitates Viral Transmission
2007 StandoutNobel
Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1–51)
1992 StandoutNobel
The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable Haemophilus influenzae from the Mouse Lung
2005 StandoutNobel
cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca2+ mobilization
1991
Recommendations for the presentation of NMR structures of proteins and nucleic acids
1998 StandoutNobel
Crystal and molecular structure of the bovine α-chymotrypsin-eglin c complex at 2.0 Å resolution
1992
R5- and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: Implication for mechanisms of sexual transmission
2006
Synthetic Inhibitors of Elastase
1994
Molecular basis of human hypertension: Role of angiotensinogen
1992 Standout
Tissue Destruction by Neutrophils
1989 Standout
Conformation of recombinant desulfatohirudin in aqueous solution determined by nuclear magnetic resonance
1989
7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway
1994
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
2002 Standout
Changes in interactions in complexes of hirudin derivatives and human α‐thrombin due to different crystal forms
1993
Nonresolving Inflammation
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Thrombin signalling and protease-activated receptors
2000 StandoutNature
The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X‐ray structures
1992
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
2 Inhibitors of Human Leukocyte Elastase
1994
Recent Developments in Inhibiting Cysteine and Serine Proteases
1990
Geometry of binding of the benzamidine‐ and arginine‐based inhibitors Nα‐(2‐naphthyl‐sulphonyl‐glycyl)‐dl ‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[Nα‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐l ‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombin
1990
Nuclear magnetic resonance solution structure of hirudin(1–51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain
1992 StandoutNobel
Amino acids of the Torpedo marmorata acetylcholine receptor .alpha. subunit labeled by a photoaffinity ligand for the acetylcholine binding site
1988
The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics
1987
Molecular determinants of the pathogenesis of disease due to non-typableHaemophilus influenzae
1999
Binding of the Recombinant Proteinase Inhibitor Eglin C from LeechHzrudo Medzcznalzsto Human Leukocyte Elastase, Bovine α-Chymotrypsin and Subtilisin Carlsberg: Thermodynamic Study
1988
Refined structure of the Hirudin-thrombin complex
1991 Nobel
Use of fragments of hirudin to investigate thrombin‐hirudin interaction
1990
Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution
2000 StandoutNobel
Directed evolution study of temperature adaptation in a psychrophilic enzyme 1 1Edited by J. A. Wells
2000 StandoutNobel
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors
1989
Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing
2000
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
1991 Standout
Primary structures of new ‘iso‐hirudins’
1989
A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Unstable Coronary Artery Disease
1997 Standout
Points of control in inflammation
2002 StandoutNature
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
2001 StandoutNature
Secretory Leukocyte Protease Inhibitor: A Macrophage Product Induced by and Antagonistic to Bacterial Lipopolysaccharide
1997
Natural protein proteinase inhibitors and their interaction with proteinases
1992 Nobel
Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity
1996 StandoutNobel
Protein–Protein Docking with Simultaneous Optimization of Rigid-body Displacement and Side-chain Conformations
2003 StandoutNobel
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
1992 StandoutNature
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
1989 Standout
Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators
2004 StandoutNobel
A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties
1990 StandoutNobel
Electrospray ionization mass spectrometry as a mechanistic tool: Mass of human leukocyte elastase and a .beta.-lactam-derived E-I complex
1993
Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism
1991 StandoutNobel
Refined 1.2 A crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c. Molecular structure of eglin and its detailed interaction with subtilisin.
1986
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Generation of an MHC Class II-Restricted T Cell Epitope by Extracellular Processing of Hepatitis δ Antigen
1998 StandoutNobel
Kinetics of subtilisin and thiolsubtilisin
1983
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.
1986
Serpin Structure, Mechanism, and Function
2002 Standout
Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.
1992
Determination and occurrence of tyrosine O-sulfate in proteins
1984
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.
1986 StandoutNobel
The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin
1990 ScienceNobel
Water as an Active Constituent in Cell Biology
2007 Standout
Amino acid sequence of serine protease inhibitor CI-1 from barley. Homology with barley inhibitor CI-2, potato inhibitor I, and leech eglin
1982
Regulation of Proteolysis at the Neutrophil-Substrate Interface by Secretory Leukoprotease Inhibitor
1990 Science
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leechHirudo medicinalisand its expression inE. coli
1984
Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein
1991 StandoutScience
Hirudin in Acute Myocardial Infarction
1996
The high‐resolution X‐ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis
1987 Standout
Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures
2014 StandoutNobel
Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c
1996
The Cation−π Interaction
1997 Standout
Dependence of formation of small disulfide loops in two-cysteine peptides on the number and types of intervening amino acids
1989
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Glycobiology: Toward Understanding the Function of Sugars
1996 Standout
Kinetics of the inhibition of thrombin by hirudin
1986
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
1990
Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin
1990
Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel
1986 StandoutNatureNobel
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.
1986
Ligand binding: proteinase-protein inhibitor interactions
1991 Nobel
Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system
1996
Structural comparison of two serine proteinase-protein inhibitor complexes: Eglin-C-subtilisin Carlsberg and CI-2-subtilisin Novo
1988 Standout
The Chemistry of Neutron Capture Therapy
1998 Standout
Similarities between human and rat leukocyte elastase and cathepsin G
1984
The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
2015
Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin by peptide boronic acids.
1984
Proteolysis and physiological regulation
1987
Molecular recognition
1991
Stereospecific assignments of side‐chain protons and characterization of torsion angles in Eglin c
1987
The Molecular Biology of Axon Guidance
1996 StandoutScience
Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.
1994 StandoutNobel
The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.
1988 StandoutNobel
Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.
1986
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1988 StandoutNatureNobel
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.
1986
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of U Seemüller being referenced
Sequence determination of eglin c using combined microtechniques of amino acid analysis, peptide isolation, and automatic Edman degradation
1983
Isolation and Characterisation of a Low Molecular Weight Inhibitor (of Chymotrypsin and Human Granulocytic Elastase and Cathepsin G) from Leeches
1977
Biochemical properties and possible therapeutic role of the elastase inhibitor eglin C.
1985
The Complete Covalent Structure of Hirudin. Localization of the Disulfide Bonds
1985
Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus
1986
Kinetics of the inhibition of human leucocyte elastase by eglin from the leech Hirudo medicinalis
1984
The acid‐stable proteinase inhibitor of human mucous secretions (HUSI‐I, antileukoprotease)
1986
Isolation and Characterization of Hirudin Isoinhibitors and Sequence Analysis of Hirudin PA
1986
Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis.
1980
Eglin c, a pharmacologically active elastase inhibitor.
1985
The complete amino acid sequence of hirudin, a thrombin specific inhibitor
1984
The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC)
1980