Standout Papers
Citation Impact
Citing Papers
Visualizing enveloping layer glycans during zebrafish early embryogenesis
2010 StandoutNobel
Copper-free click chemistry in living animals
2010 StandoutNobel
Thermodynamic Parameters for the Association of Fluorinated Benzenesulfonamides with Bovine Carbonic Anhydrase II
2006
Orthogonal Multipolar Interactions in Structural Chemistry and Biology
2005
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
2011
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
2007
Hypervalent phenyl-λ3-iodane-mediated para-selective aromatic fluorination of 3-phenylpropyl ethers
2011
Recent Progress in Direct Introduction of Fluorinated Groups on Alkenes and Alkynes by means of CH Bond Functionalization
2014
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors
2012
Understanding organofluorine chemistry. An introduction to the C–F bond
2007 Standout
Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones
2008
A Concise Synthesis of Enantioenriched Fluorinated Carbocycles
2007
Phosphate Recognition in Structural Biology
2006
The role of fluorine in medicinal chemistry
2007
Straightforward One‐Pot Synthesis of Trifluoromethyl Sulfonium Salts
2006
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
The unique role of halogen substituents in the design of modern agrochemicals
2009
Enantioselective Fluoroamination: 1,4‐Addition to Conjugated Dienes Using Anionic Phase‐Transfer Catalysis
2013
A Weak Attractive Interaction between Organic Fluorine and an Amide Group
2004
Chemo-enzymatic fluorination of unactivated organic compounds
2008 StandoutNobel
Fluorous synthesis of allylic fluorides: C–F bond formation as the detagging process
2008
Oxidative Trifluoromethylthiolations of Aryl Boronic Acids Using a Copper/O2‐Based Protocol
2012
Trifluoromethyl ethers – synthesis and properties of an unusual substituent
2008
Manganese‐Catalyzed Oxidative Benzylic C–H Fluorination by Fluoride Ions
2013
Oxidative aliphatic C-H fluorination with manganese catalysts and fluoride ion
2013
Cu-free click cycloaddition reactions in chemical biology
2010 StandoutNobel
Novel 10‐I‐3 Hypervalent Iodine‐Based Compounds for Electrophilic Trifluoromethylation
2006
Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
2008
Catalytic asymmetric fluorinations
2006
Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry
2012 StandoutNobel
Ir-catalysed formation of C−F bonds. From allylic alcohols to α-fluoroketones
2011
Room‐Temperature Nucleophilic Aromatic Fluorination: Experimental and Theoretical Studies
2006
Oxidative Trifluoromethylation of Arylboronates with Shelf‐Stable Potassium (Trifluoromethyl)trimethoxyborate
2012
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
2008
Ring Expansion Induced by DAST: Synthesis of Substituted 3‐Fluoropiperidines from Prolinols and 3‐Fluoroazepanes from 2‐Hydroxymethylpiperidines
2007
Fluorinated peptidomimetics: synthesis, conformational and biological features
2004
Simple yet functional phosphate-loop proteins
2018 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Practical Synthesis of Fluorine-Containing α- and β-Amino Acids: Recipes from Kiev, Ukraine
2009
Fluorine in medicinal chemistry
2007 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Synthesis of β-fluoroenones and their reductive rearrangement in aqueous media
2013
Ring Expansion of Cyclic β-Amino Alcohols Induced by Diethylaminosulfur Trifluoride: Synthesis of Cyclic Amines with a Tertiary Fluorine at C3
2012
Review of recent advances in nucleophilic C–F bond-forming reactions at sp3 centers
2014
A Weak Attractive Interaction between Organic Fluorine and an Amide Group
2004
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Catalytic Asymmetric Fluorination of α-Chloro-β-ketoesters in the Presence of Chiral Palladium Complexes
2007
An expeditious synthesis of 4-fluoropiperidines via aza-Prins cyclization
2010
Straightforward One‐Pot Synthesis of Trifluoromethyl Sulfonium Salts
2006
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
Nucleophilic Deoxyfluorination of Catechols
2011
Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
2013 Standout
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Thiourea‐Catalyzed Enantioselective Fluorination of β‐Keto Esters
2012
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
Palladium‐Catalyzed CF Bond Formation via Directed CH Activation
2014
Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes
2015
Catalytic Enantioselective Fluorination Reactions of α-Cyano Acetates and α-Cyanophosphonates Using Chiral Palladium Complexes
2007
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
A Concise Synthesis of Enantioenriched Fluorinated Carbocycles
2007
Stereoselective α-Fluorination of N-Acyloxazolidinones at Room Temperature within 1 h
2014
A Two‐Step Sequence to Ethyl α‐Fluorocyclopropanecarboxylates Through MIRC Reaction of Ethyl Dichloroacetate and Highly Regioselective Fluorination
2013
Introducing a new radical trifluoromethylation reagent
2015
Artificial Transfer Hydrogenases Based on the Biotin−(Strept)avidin Technology: Fine Tuning the Selectivity by Saturation Mutagenesis of the Host Protein
2006
Successful fluorine-containing herbicide agrochemicals
2014
Synthesis of γ-Monofluorinated Goniothalamin Analogues via Regio- and Stereoselective Ring-Opening Hydrofluorination of Epoxide
2011
Late-Stage Deoxyfluorination of Alcohols with PhenoFluor
2013
Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine−Norbornene Cycloaddition
2010 StandoutNobel
Copper-free click chemistry for dynamic in vivo imaging
2007 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles
2009
Tuning P450 Enzymes as Oxidation Catalysts
2012
Catalytic Enantioselective Fluorination of α‐Chloro‐β‐keto Esters in the Presence of Chiral Nickel Complexes
2010
Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles
2009
A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors
2010 StandoutNobel
An Efficient Synthesis of Fluorinated Azaheterocycles by Aminocyclization of Alkenes
2013
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery
2015
A General Approach to (Trifluoromethoxy)pyridines: First X‐ray Structure Determinations and Quantum Chemistry Studies
2010
α-Fluorinated Ethers, Thioethers, and Amines: Anomerically Biased Species
2005
Orthogonale multipolare Wechselwirkungen in chemischen und biologischen Strukturen
2005
Stereospecific benzylic dehydroxyfluorination reactions using Bio’s TMS-amine additive approach with challenging substrates
2010
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
2009
A Continuous-Flow Protocol for Light-Induced Benzylic Fluorinations
2014
The Many Roles for Fluorine in Medicinal Chemistry
2008 Standout
Fluorogenic Azidofluoresceins for Biological Imaging
2012 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Cooperative Reactivity in an Extended-Viologen-Based Cyclophane
2016 StandoutNobel
Folding of Oligoviologens Induced by Radical–Radical Interactions
2014 StandoutNobel
Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination
2013
Fluorophore Targeting to Cellular Proteins via Enzyme-Mediated Azide Ligation and Strain-Promoted Cycloaddition
2012 StandoutNobel
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
2017
Boron Trifluoride Etherate Functioning as a Fluorine Source in an Iodosobenzene-Mediated Intramolecular Aminofluorination of Homoallylic Amines
2014
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2‐Containing Trisubstituted Cyclopropanes
2020
Human Pharmaceuticals in the Aquatic Environment: A Challenge to Green Chemistry
2007
Difluorobenzocyclooctyne: Synthesis, Reactivity, and Stabilization by β-Cyclodextrin
2010 StandoutNobel
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
Oxidative Enantioselective α‐Fluorination of Aliphatic Aldehydes Enabled by N‐Heterocyclic Carbene Catalysis
2014
Enantioselective fluorination of α-chloro-β-keto phosphonates in the presence of chiral palladium complexes
2013
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Large-scale Mannich-type reactions of (SS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine with C-nucleophiles
2014
Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides
2011
Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones
2008
Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions
2014
Nucleophilic (phenylsulfonyl)difluoromethylation of alkyl halides using PhSO2CF2SiMe3: preparation of gem-difluoroalkenes and trifluoromethyl compounds
2010
Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones
2010 StandoutNobel
Asymmetric Palladium-Catalyzed Directed Intermolecular Fluoroarylation of Styrenes
2014
Structure of Bis(trifluoromethyl)cuprate and Its Role in Trifluoromethylation Reactions
2008
Synthese von 11C‐, 18F‐, 15O‐ und 13N‐Radiotracern für die Positronenemissionstomographie
2008
Enantioselective Fluorination of β-Ketoesters Catalyzed by Chiral Sodium Phosphate: Remarkable Enhancement of Reactivity by Simultaneous Utilization of Metal Enolate and Metal Phosphate
2013
Enantioselective Organocatalytic α-Fluorination of Cyclic Ketones
2011
Metal-Free, Efficient Oxyfluorination of Olefins for the Synthesis of α-Fluoroketones
2014
A Bioorthogonal Quadricyclane Ligation
2011 StandoutNobel
HBF4·OEt2 as a versatile reagent for the Hosomi–Sakurai allylation and Prins cyclization: one-pot synthesis of symmetrical 4-fluorotetrahydropyrans
2010
Facilitating the Design of Fluorinated Drugs
2009
Preparation of Trifluoromethylated Dihydrocoumarins, Indanones, and Arylpropanoic Acids by Tandem Superacidic Activation of 2-(Trifluoromethyl)acrylic Acid with Arenes
2010 Nobel
Tuning the Reactivity of Difluoromethyl Sulfoximines from Electrophilic to Nucleophilic: Stereoselective Nucleophilic Difluoromethylation of Aryl Ketones
2012
Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
2015 StandoutNobel
Diastereodivergent Hydroxyfluorination of Cyclic and Acyclic Allylic Amines: Synthesis of 4-Deoxy-4-fluorophytosphingosines
2012
Highly Enantioselective Fluorination of Unprotected 3-Substituted Oxindoles: One-Step Synthesis of BMS 204352 (MaxiPost)
2012
A novel improvement in ArLPdF catalytic fluorination of aromatic compounds
2011
Fluorine in Peptide Design and Protein Engineering
2005
New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines
2009
DNA-Based Asymmetric Catalysis: Sequence-Dependent Rate Acceleration and Enantioselectivity
2008 StandoutNobel
New fluorinated functional materials
2005
Decarboxylative trifluoromethylation of aryl halides using well-defined copper–trifluoroacetate and –chlorodifluoroacetate precursors
2010
Imaging the glycome
2008 StandoutNobel
Highly Diastereoselective and General Synthesis of Primary β-Fluoroamines
2011
Facile One-Pot Synthesis of N-Difluoromethyl-2-pyridone Derivatives
2006
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Halogen Exchange (Halex) Reaction of 5‐Iodo‐1,2,3‐triazoles: Synthesis and Applications of 5‐Fluorotriazoles
2012
Fluorine chemistry at the millennium
2004
Fluorine in medicinal chemistry: A review of anti-cancer agents
2006
Ring-Opening Hydrofluorination of 2,3- and 3,4-Epoxy Amines by HBF4·OEt2: Application to the Asymmetric Synthesis of (S,S)-3-Deoxy-3-fluorosafingol
2011
Beyond the Balz–Schiemann Reaction: The Utility of Tetrafluoroborates and Boron Trifluoride as Nucleophilic Fluoride Sources
2014
Room‐Temperature Nucleophilic Aromatic Fluorination: Experimental and Theoretical Studies
2006
Selective Anti-Markovnikov Cyclization and Hydrofluorination Reaction in Superacid HF/SbF5: A Tool in the Design of Nitrogen-Containing (Fluorinated) Polycyclic Systems
2013
Rapid, General Access to Chiral β-Fluoroamines and β,β-Difluoroamines via Organocatalysis
2009
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Silver-mediated fluorination, trifluoromethylation, and trifluoromethylthiolation of arynes
2013
Asymmetric Enamine Catalysis
2007 StandoutNobel
Regio- and Stereoselective Synthesis of Fluoroalkenes by Directed Au(I) Catalysis
2009
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
2008 StandoutNobel
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Nucleophilic Fluorination of Triflates by Tetrabutylammonium Bifluoride
2008
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
The Cation−π Interaction
2012
Catalytic Asymmetric Synthesis of Thiols
2014 StandoutNobel
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Real-Time Bioluminescence Imaging of Glycans on Live Cells
2010 StandoutNobel
Asymmetric Fluorination of Enamides: Access to α-Fluoroimines Using an Anionic Chiral Phase-Transfer Catalyst
2012
Vanadium-catalyzed C(sp3)–H fluorination reactions
2014
Enantioselective Organocatalytic α-Fluorination of Aldehydes
2005
Fluorinated organophosphates for biomedical targets
2008
Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments
2008 Standout
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Synthesis of Trifluoromethyl-Containing Vicinal Diamines by Asymmetric Decarboxylative Mannich Addition Reactions
2015
Works of U. Obst-Sander being referenced
Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket
2006
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKaand binding affinity and evidence for intermolecular C–F⋯CN interactions
2004
Quantification of Cation–π Interactions in Protein–Ligand Complexes: Crystal‐Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand
2005
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
2004
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
2005
A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values
2006
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
2006
Fluorine in Medicinal Chemistry
2004 Standout
Quantifizierung von Kation‐π‐Wechselwirkungen in Protein‐Ligand‐Komplexen: Kristallstrukturanalyse eines Komplexes von Faktor Xa und einem quartären Ammonium‐Ion‐Liganden
2005
Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors
2006