Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Klf4 reverts developmentally programmed restriction of ground state pluripotency
2009
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130
2000
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
2001
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
A new protein containing an SH2 domain that inhibits JAK kinases
1997 Nature
Structural and functional insights into the B30.2/SPRY domain
2006
Acromegaly
2006 Standout
The Carboxyl-terminal Domains of gp130-related Cytokine Receptors Are Necessary for Suppressing Embryonic Stem Cell Differentiation
1999
MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase
2001
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
1993 StandoutNatureNobel
Animal models of human disease: zebrafish swim into view
2007 Standout
Requirement for a functional Rb-1 gene in murine development
1992 Nature
Immobilization of leukemia inhibitory factor (LIF) to culture murine embryonic stem cells
2004
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
Control of the Embryonic Stem Cell State
2011
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
1991 Standout
Identification and expression cloning of a leptin receptor, OB-R
1995 Standout
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Clonally Derived Human Embryonic Stem Cell Lines Maintain Pluripotency and Proliferative Potential for Prolonged Periods of Culture
2000
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
SOCS-1/SSI-1-Deficient NKT Cells Participate in Severe Hepatitis through Dysregulated Cross-Talk Inhibition of IFN-γ and IL-4 Signaling In Vivo
2001
The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2
2001
Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling
1998
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells
1989 Nature
The paradigm of IL-6: from basic science to medicine.
2002
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
2011
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
The von Hippel–Lindau tumor suppressor protein
2001 StandoutNobel
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
1990
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
2008
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
2016
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
1989 StandoutNature
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
1991 Nature
Functional immobilization of signaling proteins enables control of stem cell fate
2008
The biology of Stat4 and Stat6
2000
Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway
1998
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
2003
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
Self Renewal of Embryonic Stem Cells in the Absence of Feeder Cells and Exogenous Leukaemia Inhibitory Factor
1997
Dimerization of cell surface receptors in signal transduction
1995
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
1996
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
1998 StandoutNobel
SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling
2000
STATs in oncogenesis
2000 Standout
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
2005
Structure and function of a new STAT-induced STAT inhibitor
1997 Nature
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
A genetic map of the mouse suitable for typing intraspecific crosses.
1992
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
1992 StandoutNature
Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia
2016
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
1999
Cloning and Characterization of Novel CIS Family Genes
1997
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Cytokine Signaling in 2002
2002 Standout
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
1988 Nature
Signalling, cell cycle and pluripotency in embryonic stem cells
2002
Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells
1999
SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine Kinase
1997
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
CD4+CD25+ Immunoregulatory T Cells
2002
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
1999
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Embryo-Derived Stem Cells: Of Mice and Men
2001
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture
1991
Essential role of STAT3 for embryonic stem cell pluripotency
1999
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Growth Hormone Receptor Antagonists: Discovery, Development, and Use in Patients with Acromegaly
2002
Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells.
1991
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.
1992
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
2000
Transcription Elongation and Human Disease
1999
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
JAKS AND STATS: Biological Implications
1998 Standout
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
1995
Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
1997 StandoutScience
SOCS Proteins: Negative Regulators of Cytokine Signaling
2001 Standout
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
The SOCS proteins: a new family of negative regulators of signal transduction
1998
Hematopoietic Commitment During Embryonic Stem Cell Differentiation in Culture
1993
Reactivation of the Paternal X Chromosome in Early Mouse Embryos
2004 StandoutScienceNobel
Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes
1991
Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines
2001
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
2001
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
1998
Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.
1991
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor
2000
Immobilization of Leukemia Inhibitory Factor (LIF) to Culture Murine Embryonic Stem Cells
2004
Conversion of the biological specificity of murine to human leukemia inhibitory factor by replacing 6 amino acid residues.
1994
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
2003
Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression
2005
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
1994
Chimeric analysis of T (Brachyury) gene function
1993
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity
1990
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
1998
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation
2001
Hematopoietic commitment during embryonic stem cell differentiation in culture.
1993
A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis
2002
Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element
1993 Science
Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor
1992 Science
Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.
1991
Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development
1995
A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells
2007
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
YACs to the rescue
1993 StandoutNatureNobel
Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines
1994
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
2002
Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion
1998
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
2014 StandoutNobel
Generation and Analysis of Interleukin-4 Deficient Mice
1991 Science
Direct Neural Fate Specification from Embryonic Stem Cells
2001
Works of Tracy A. Willson being referenced
Suppressor screen in Mpl -/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
2004
SOCS2 negatively regulates growth hormone action in vitro and in vivo
2005
A family of cytokine-inducible inhibitors of signalling
1997 StandoutNature
Molecular Cloning of Two Novel Transmembrane Ligands for Eph-Related Kinases (LERKS) that are Related to LERK-2
1996
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
1988 StandoutNature
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity
2011
Gigantism in mice lacking suppressor of cytokine signalling-2
2000 Nature
Distinct Roles for Leukemia Inhibitory Factor Receptor α-Chain and gp130 in Cell Type-specific Signal Transduction
1997
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.
1994
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
1999
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.
1988
Production of Leukemia Inhibitory Factor in Escherichia coli by a Novel Procedure and Its Use in Maintaining Embryonic Stem Cells in Culture
1989
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
1998
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
2000
Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.
1990
SOCS2 negatively regulates growth hormone action in vitro and in vivo
2005
Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant.
1993
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
1996
Twenty proteins containing a C-terminal SOCS box form five structural classes
1998
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
2001
Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*
1990