Citation Impact
Citing Papers
Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
2006
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks
2013
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells
2010
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
2012 StandoutScience
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
2005
Cerebral cortex expansion and folding: what have we learned?
2016
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
2007 Science
Ataxia telangiectasia mutated activation by transcription‐ and topoisomerase I‐induced DNA double‐strand breaks
2009 Nobel
Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair
2008
An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells
2015 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci
2004
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
2013
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
2005 Nature
H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase
2007
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
2007
DNA-PKcs and ATM co-regulate DNA double-strand break repair
2009
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice
2010
Structural and functional analysis of the Crb2–BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
2008
Cdk5rap2 exposes the centrosomal root of microcephaly syndromes
2011
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway
2011
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
ATR: an essential regulator of genome integrity
2008
The Human Transcription Factors
2018 Standout
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein
2010 StandoutNobel
The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development
2008
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
2006
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
2009
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
2013 Standout
DNA Damage, Aging, and Cancer
2009 Standout
ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells
2013
Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation
2008
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2005
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Novel CENPJ mutation causes Seckel syndrome
2010
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
2005
Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response
2013 StandoutNobel
DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions
2010
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
γH2AX and cancer
2008
Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities
2017
Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1
2013
Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex
2006 StandoutNobel
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
2009
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
2011 StandoutNobel
The cellular response to general and programmed DNA double strand breaks
2004
A thermostable Cas9 with increased lifetime in human plasma
2017 StandoutNobel
Early events in the mammalian response to DNA double-strand breaks
2008
Defective DNA Repair and Neurodegenerative Disease
2007
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
2008
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break
2004
An improved zinc-finger nuclease architecture for highly specific genome editing
2007
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
The Hallmarks of Aging
2013 Standout
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Emerging links between the biological clock and the DNA damage response
2007
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
2009 Standout
A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment
2013
Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
2005
Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth
2008
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage
2015
Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)
2011 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Mechanisms for Initiating Cellular DNA Replication
2013
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
2004
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
2009
ATR signalling: more than meeting at the fork
2011
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation
2006
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
The ATM-mediated DNA-damage response: taking shape
2006
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
2007
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal
2012 StandoutNobel
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
2004
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Non-homologous end-joining, a sticky affair
2007
Recruitment of DNA Damage Checkpoint Proteins to Damage in Transcribed and Nontranscribed Sequences
2005 StandoutNobel
Works of Tom Stiff being referenced
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
2004
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome
2011
Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1
2008
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
2007
Nbs1 is required for ATR‐dependent phosphorylation events
2004
DNA double-strand break repair within heterochromatic regions
2012
Chromosome breakage after G2 checkpoint release
2007