Citation Impact
Citing Papers
Visualizing enveloping layer glycans during zebrafish early embryogenesis
2010 StandoutNobel
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
2009 StandoutScience
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells
2004
Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells
2003
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
2009
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development
2008
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells
2015 Science
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
ZBTB1 is a determinant of lymphoid development
2011 StandoutNobel
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
2003 Science
Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
2013
Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
Bim is a suppressor of Myc-induced mouse B cell leukemia
2004
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
2006
Generalized Resistance to Thymic Deletion in the NOD Mouse
2004
Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis
2005
The metabolic life and times of a T‐cell
2010
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
How the Bcl-2 family of proteins interact to regulate apoptosis
2006
Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis
2005
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
2007
Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs
2002
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
2008 Nature
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
2012
Systemic inflammation in chronic obstructive pulmonary disease
2003
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Autoimmune Diseases
2001
Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo
2012
The Bcl-2 Protein Family
2000
Pathogenesis and therapy of psoriasis
2007 StandoutNature
Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim
2002
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
2008
The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL
2009
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release
2001
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
2002
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
2005
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
2002
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
2003
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
2002 StandoutNature
Mammalian microRNAs predominantly act to decrease target mRNA levels
2010 StandoutNature
Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
2004
The Bcl2 family: regulators of the cellular life-or-death switch
2002 Standout
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
2005
The impact of microRNAs on protein output
2008 StandoutNature
The biochemistry of apoptosis
2000 StandoutNature
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa
2013
Apoptosis and cancer: the genesis of a research field
2009
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
2002 Nature
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
2011
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death
2000
Expansion and evolution of cell death programmes
2008
Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
2009
Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation
2004
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
Cell Death
2009
Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis
2001
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
2000
Ways of dying: multiple pathways to apoptosis
2003
A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak
2007
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Osteoclast differentiation and activation
2003 StandoutNature
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage
2004
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
2007
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
2012
MicroRNAs and Cancer: Short RNAs Go a Long Way
2009
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
2011 StandoutNobel
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
2013
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance
2007
LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis
2009
DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa
2012
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
2003
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest
2007
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice
2012
Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim
2001
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
Mechanisms maintaining peripheral tolerance
2009
The role of BH3-only proteins in the immune system
2005
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
2010 StandoutNature
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
2003
Life in the balance: how BH3-only proteins induce apoptosis
2005
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
2002 Nature
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
2007
Cytochrome c: functions beyond respiration
2008
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
2008
Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
2006
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Src-family kinases: rheostats of immune cell signaling
2004
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway
2006
Life-or-death decisions by the Bcl-2 protein family
2001
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
2007
Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
2007
JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis
2003
Foxo‐mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3‐only protein
2013
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
2001
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
2007
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
2002 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
The Pathophysiology of Mitochondrial Cell Death
2004 StandoutScience
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
2003
The Bcl-2 family: roles in cell survival and oncogenesis
2003
Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors
2004
Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
2010
Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage–colony-stimulating factor and interleukin-4
2002
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
2013
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
2007 Science
Regulatory phosphorylation of Bim: sorting out the ERK from the JNK
2005
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal
2002
The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2
2002
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
2001 Science
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
1999
RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution
2002
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
2006
Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1
2000
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Apoptosis Signaling
2000
BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo
2005
RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice
2016
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
2012
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
2005
Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
2006
FOXO Transcription Factors as Regulators of Immune Homeostasis: Molecules to Die for?
2003 Standout
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages
2006
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
2006
Proapoptotic BH3-Only Bcl-2 Family Member Bik/Blk/Nbk Is Expressed in Hemopoietic and Endothelial Cells but Is Redundant for Their Programmed Death
2004
The expanding role of mitochondria in apoptosis.
2001 Standout
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
2007
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
2010
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
2007
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
2003
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
2013 Standout
Loss of BH3-only Protein Bim Inhibits Apoptosis of Hemopoietic Cells in the Fetal Liver and Male Germ Cells but Not Neuronal Cells in Bcl-x-deficient Mice
2008
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
2010
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
2008
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad
2009
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
2003 Nature
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
2004 StandoutScience
Works of Tom Kay being referenced
Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity
1999 Science
Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response
2002